교수
석차옥 Seok, Chaok
연구내용
Our ultimate goal is to understand detailed mechanisms underlying biological phenomena using computational and theoretical tools, and to contribute to curing diseases using the knowledge obtained from such studies. We are currently developing mathematical and computational techniques to model and to simulate biomolecules more efficiently and accurately. An example is an analytical loop closure method that can be used to model flexibilities in proteins loops and cyclic peptides. We will apply these methods to prediction of protein structures and biomolecular interactions, and also extend such experiences to design of new drugs and proteins.
학력
- Ph.D. Chemistry, University of Chicago, USA, 1998
- M.S. Chemistry, University of Chicago, USA, 1995
- B.S. Chemistry, Seoul National University, Korea, 1993
주요 경력
- Research Associate, University of Chicago, 1999
- Research Associate, Massachusetts Institute of Technology, 2000
- Research Associate, University of California, San Francisco, 2000-2004
주요 논문
- J. Yang, S. Kwon, S.-H. Bae, K. M. Park, C. Yoon, J.-H. Lee, and C. Seok, GalaxySagittarius: Structure- and Similarity-Based Prediction of Protein Targets for Druglike Compounds, J. Chem. Inf. Model, 60 (6), 3246-3254 (2020).
- J. Yang, M. Baek, and C. Seok, GalaxyDock3: Protein-ligand docking that considers the full ligand conformational flexibility, J. Comput. Chem. 40 (31), 2739-2748 (2019).
- J. Won, G. R. Lee, H. Park, and C. Seok, GalaxyGPCRloop: Template-Based and Ab Initio Structure Sampling of the Extracellular Loops of G-Protein-Coupled Receptors, J. Chem. Inf. Model, 58 (6), 1234-1243 (2018).
- G. R. Lee and C. Seok, Galaxy7TM: Flexible GPCR-ligand docking by structure refinement, Nucleic Acids Res. 44 (W1), W502-506 (2016).
- H. Park, H. Lee, and C. Seok, High-resolution Protein-protein Docking by Global Optimization: Recent Advances and Future Challenges, Current Opinion in Structural Biology, 35, 24-31 (2015).
- H. Lee, L. Heo, M. S. Lee, and C. Seok, GalaxyPepDock: a protein-peptide docking tool based on interaction similarity and energy optimization, Nucleic Acids Res. 43 (W1), W431-W435 (2015).
논문 검색
110. Discovery of highly active kynureninases for cancer immunotherapy through protein language model
Hyunuk Eom, Sukhwan Park, Kye Soo Cho, Jihyeon Lee, Hyunbin Kim, Stephanie Kim, Jinsol Yang, Young-Hyun Han, Juyong Lee, Chaok Seok, Myeong Sup Lee, Woon Ju Song, Martin Steinegger
Changsoo Lee, Jonghun Won, Seongok Ryu, Jinsol Yang, Nuri Jung, Hahnbeom Park, Chaok Seok
Hyeonuk Woo, Yubeen Kim, Chaok Seok
Won Hoon Choi, Yejin Yun, Insuk Byun, Sumin Kim, Seho Lee, Jiho Sim, Shahar Levi, Seo Hyeong Park, Jeongmoo Jun, Oded Kleifeld, Kwang Pyo Kim, Dohyun Han, Tomoki Chiba, Chaok Seok, Yong Tae Kwon, Michael H. Glickman, Min Jae Lee
Seho Lee, Chaok Seok, Hahnbeom Park
Changsoo Lee, Jinsol Yang, Sohee Kwon, Chaok Seok
Jihyeon Lee, Chaok Seok, Sihyun Ham, Song-Ho Chong
Juyeon Seo, Minsu Park, Dongmi Ko, Seongjae Kim, Jung Min Park, Soeun Park, Kee Dal Nam, Lee Farrand, Jinsol Yang, Chaok Seok, Eunsun Jung, Yoon-Jae Kim, Ji Young Kim & Jae Hong Seo
Hyunook Kang 1 4, Chaehee Park 1 4, Yeol Kyo Choi 2, Jungnam Bae 1, Sohee Kwon 3, Jinuk Kim 1, Chulwon Choi 1, Chaok Seok, Wonpil Im 2, Hee-Jung Choi
Sumin Lee, Seeun Kim, Gyu Rie Lee, Sohee Kwon, Hyeonuk Woo, Chaok Seok, Hahnbeom Park
