입학 및 졸업 관련양식
연구비 및 여행관련양식
Building on Tradition
Soaring into the Future
SNU Department of Chemistry
Integrating Research and Teaching
to Advance Frontiers in Chemistry
SNU Department of Chemistry
Department of Chemistry
Seoul National University
Creative, Collaborative, and Innovative
Seoul National University
박승범 교수 연구팀 퇴행성 뇌신경 질환 치료의 새로운 작용기전을 밝혀
치매 파킨슨병과 같은 퇴행성 뇌신경 질환의 병변중의 하나인 타우단백질의 응집을 저해하는 신규 약물 후보물질을 표현형 기반 스크리닝으로 발굴 세포내 작용기작을 밝히고 동물 모델에서 효능을 확인해 퇴행성 뇌질환 치료제 개발에 실마리를 얻었다.
수소기체 얻을 수 있는 물 전기분해 촉매 개발
물 전기분해를 통한 수소생산은 수소경제를 완성하기 위해 필수적이기 때문에 중요하게 인식되고 있다. 이에 연구팀은 이차전지 양극소재인 리튬 코발트 산화물(LiCoO2)에 염화이온(Cl-)을 미세하게 도핑하는 방법으로 경제성, 효율성, 수명을 현저히 향상시킨 물 전기분해 양(+)극 촉매를 개발했다.
한국연구재단 "서울대, 생합성 모사한 비타민B3 합성법 개발"
지질대사에 필수적인 비타민 B3가 포함된 다양한 저분자 물질을 단일반응으로 얻을 수 있는 합성법이 소개됐다. 이는 다양한 생리활성 분자를 설계할 수 있는 실마리가 될 것으로 기대된다.
'껌만 씹어도 배부른 이유' 찾았다
19세기 중반부터 20세기 중반까지 생리학자들은 동물의 소화관에 구멍을 내서 물이 위에서 새어나가게 하거나 위에 풍선을 넣고 바람을 불어넣어 부풀린 뒤 먹이를 먹게 하는 실험을 진행했다.
지구온난화로 인한 이상 고온 대응 식물 생존 원리 발견
최근 이상 기온에 대응해 식물은 자체적으로 적극적인 방어 전략을 구축하고 능동적으로 적응함으로써 고온에서도 최적의 생장을 유지하고 나아가 고온에 의한 세포 피해나 식물 자체가 고사하는 상황을 효율적으로 극복하는 분자적 원리를 세계 최초로 증명했다.
장내 병원균의 감염에 필수적인 단백질의 구조 규명
서울대학교와 노트르담대학교 국제공동연구팀이 '장내 병원균 감염에 필수적인 단백질 구조'를 규명했다.
삼성 지원 연구팀, 세계 최초 DNA 컴퓨팅 인공신경망 구현
삼성이 지원한 서울대 화학부 남좌민 교수 연구팀이 DNA 컴퓨팅 아키텍처를 이용한 나노입자 인공신경망을 세계 최초로 구현했다.
고분자 단백질 스스로 형성하는 ‘자기조립’ 기술 개발
인공 효소나 생촉매, 생체물질 합성의 기반이 될 수 있는 단백질 자기조립체 합성법이 개발됐다. 송윤주 서울대 화학부 교수 연구팀은 안정적인 구조의 단백질 자기조립체를 합성할 수 있는 기술을 개발했다고 11일 밝혔다.
공지사항 / 세미나
2021년 지능정보서비스(인터넷·스마트폰) 과의존 예방교육 이수 안내
2021학년도 1학기 국가근로장학사업 3차 학생신청 안내
2021년 대학생청소년교육지원 및 다문화·탈북학생 멘토링 장학금 지원사업 멘토 모집 안내(~4/23)
영상 정보처리기기(CCTV) 표준 지침 안내/ CCTV 촬영장소 고지
정규세미나 - 김종서 교수 (서울대학교 생명과학부)
Toward next generation molecular interactomics
정규세미나 - 곽경원 교수 (고려대학교 화학과)
In-Operando Time-Resolved Vibrational Spectroscopy
정규세미나 - 박철민 교수 (UNIST 화학과)
Reactive Intermediates in Organic Synthesis : from Small to Macro Molecules
정규세미나 - 정회성 교수 (NIH 화학과)
Heterogeneous binding and aggregation of disordered proteins from single-molecule fluorescence spectroscopy
정규세미나 - 황대희 교수 (서울대학교 생명과학부)
Systems medicine approaches
정규세미나 - 조천규 교수 (한양대학교)
Modified Fischer indolization for the synthesis of medium sized ring-fused indole alkaloids
Sequence-Dependent Kink Formation in Short DNA Loops: Theory and Molecular Dynamics Simulations
Kink formation is essential in highly bent DNA complexed with gene regulatory proteins such as histones to release the bending stress stored within the DNA duplex. Local opening of the double-stranded DNA creates a sharp turn along the specific sequence, which leads to the global bending of the DNA strand. Despite the critical role of kink formation, it is still challenging to predict the position of kink formation for a given DNA sequence. In this study, we propose a theoretical model and perform molecular dynamics simulations to quantify the sequence-dependent kink probability of a strongly bent DNA. By incorporating the elastic bending energy and the sequence-specific thermodynamic parameters, we investigate the importance of the DNA sequence on kink formation. We find that the sequence with TA dinucleotide repeats flanked by GC steps increases the kink propensity by more than an order of magnitude under the same bending stress. The number of base pairs involved in the local opening is found to be coupled with the sequence-specific bubble formation free energy. Our study elucidates the molecular origin of the sequence heterogeneity on kink formation, which is fundamental to understanding protein–DNA recognition.
A nanoscale Cu 2-x Se ultrathin film deposited via atomic layer deposition and its memristive effects
An ultrathin ﬁlm of copper selenide 50 nm thick was deposited using a home-made atomic layer deposition apparatus. Synthesized copper pivalate and bis(triethylsilyl) selenide precursors were used. The deposition rate at 160 °C was 0.48 Å per atomic layer deposition cycle. The thickness was monitored by an in situ ellipsometer and further analyzed by an atomic force microscope. The composition and structure of the ﬁlm were conﬁrmed by x-ray photoelectron spectroscopy, Raman spectroscopy, and x-ray diffraction to be Cu1.16Se. The ﬂuorine-doped tin oxide/Cu1.16Se/tungsten wire memristor was fabricated and its memristive effect was investigated. The non-linear I–V curve and spike-timing-dependent plasticity of our Cu1.16Se memristor demonstrate that the short-term and long-term potentiation that occurs in a human brain can be mimicked by adjusting voltage-pulse intervals. A memristor is the electrical equivalent of a synapse. Our memristor has a 1 ms switching time, a 400 s retention time, Roff/on = 2, and reproducibility over 1000 cycles.
Challenge to overcome current limitations of cell-penetrating peptides
The penetration of biological membranes is a prime obstacle for the delivery of pharmaceutical drugs. Cell-penetrating peptide (CPP) is an efficient vehicle that can deliver various cargos across the biological membranes. Since the discovery, CPPs have been rigorously studied to unveil the underlying penetrating mechanism as well as to exploit CPPs for various biomedical applications. This review will focus on the various strategies to overcome current limitations regarding stability, selectivity, and efficacy of CPPs.
Click-To-Twist Strategy To Build Blue-to-Green Emitters: Bulky Triazoles for Electronically Tunable and Thermally Activated Delayed Fluorescence ACS Appl. Mater. Interfaces 2021, 13,
Discovery of a new chemical moiety is the foundation to build new functional materials. For charge-transfer-type thermally activated delayed fluorescence (TADF) emitters, donor, acceptor, and π-spacer are the three key structural components. We invented a “click-to-twist” strategy to prepare a triazole-based acceptor unit that allows for a systematic modulation of the electronic and steric properties to control the excited-state photophysics. Taking the modular approach, six different emitters were prepared by varying the donor strength and π-spacer sterics for mix-and-match. These materials display deep blue to sky blue emissions in solutions, as well as apparent TADF characteristics in doped films. Organic light emitting diodes fabricated with these new TADF materials exhibit high external quantum efficiencies of up to 20.7% and maximum luminance of 6823 cd m–2. Building upon an intuitive and operationally straightforward method to build sterically congested molecules, this work showcases a new strategy to diversify TADF emitters by a mechanism-based design and modular synthesis.
DNA-Engineerable Ultraflat-Faceted Core–Shell Nanocuboids with Strong, Quantitative Plasmon-Enhanced Fluorescence Signals for Sensitive, Reliable MicroRNA Detection
There has been enormous interest in understanding and utilizing plasmon-enhanced fluorescence (PEF) with metal nanostructures, but maximizing the enhancement in a reproducible, quantitative manner while reliably controlling the distance between dyes and metal particle surface for practical applications is highly challenging. Here, we designed and synthesized fluorescence-amplified nanocuboids (FANCs) with highly enhanced and controlled PEF signals, and fluorescent silica shell-coated FANCs (FS-FANCs) were then formed to fixate the dye position and increase particle stability and fluorescence signal intensity for biosensing applications. By uniformly modifying fluorescently labeled DNA on Au nanorods and forming ultraflat Ag shells on them, we were able to reliably control the distance between fluorophores and Ag surface and obtained an ∼186 fluorescence enhancement factor with these FANCs. Importantly, FS-FANCs were utilized as fluorescent nanoparticle tags for microarray-based miRNA detection, and we achieved >103-fold higher sensitivity than commercially available chemical fluorophores with 100 aM to 1 pM dynamic range.
One-Pot Heterointerfacial Metamorphosis for Synthesis and Control of Widely Varying Heterostructured Nanoparticles
Despite remarkable facileness and potential in forming a wide variety of heterostructured nanoparticles with extraordinary compositional and structural complexity, one-pot synthesis of multicomponent heterostructures is largely limited by the lack of fundamental mechanistic understanding, designing principles, and well-established, generally applicable chemical methods. Herein, we developed a one-pot heterointerfacial metamorphosis (1HIM) method that allows heterointerfaces inside a particle to undergo multiple equilibrium stages to form a variety of highly crystalline heterostructured nanoparticles at a relatively low temperature (<100 °C). As proof-of-concept experiments, it was shown that widely different single-crystalline semiconductor–metal anisotropic nanoparticles with synergistic chemical, spectroscopic, and band-gap-engineering properties, including a series of metal–semiconductor nanoframes with high structural and compositional tunability, can be formed by using the 1HIM approach. 1HIM offers a new paradigm to synthesize previously unobtainable or poorly controllable heterostructures with unique or synergistic properties and functions.
Conducting polymers as anion-responsive chemical fuses
We report the first example of anion-selective disassembly of conducting polymers. With polymer-modified electrodes, such an externally triggered macroscopic transition leads to ON–OFF binary signaling of a chemical fuse as a preventive measure against specific chemicals in solution. This unprecedented mode of operation is driven by N–H⋯X− hydrogen bonding of biimidazole units fused orthogonally onto the polythiophene backbone, and conveniently monitored by a simple electrical setup without the need for a sophisticated optical device.
Intracellular delivery of immunoglobulin G at nanomolar concentrations with domain Z-fused multimeric α-helical cell penetrating peptides
A new vehicle is designed for the intracellular delivery of antibodies at nanomolar concentrations by combination of domain Z, a small affibody with strong binding affinity to Fc regions of immunoglobulin G (IgG), and the multimers of LK sequences, α-helical cell penetrating peptides (CPP) with powerful cell penetrating activities. Domain Z and multimeric LK are fused together to form LK-domain Z proteins. The LK-domain Z can bind with IgG at a specific ratio at nanomolar concentrations by simple mixing. The IgG/LK-domain Z complexes can successfully penetrate live cells at nanomolar concentration and the delivery efficiency is strongly dependent upon the concentrations of IgG/LK-domain Z complex as well as the species and subclasses of IgGs. The IgG/LK-domain Z complexes penetrate cells via ATP-dependent endocytosis pathway and the majority of delivered IgG seems to escape endosome to cytosol. Remarkably, the delivered IgGs are able to control the targeted intracellular signaling pathway as shown in the down-regulation of pro-survival genes by the delivery of anti-NF-κB using an LK-domain Z vehicle with a cathepsin B-cleavable linker between the LK sequence and domain Z. The simple but very efficient intracellular delivery method of antibodies at nanomolar concentrations is expected to facilitate profound understanding of cell mechanisms and development of new future therapeutics on the basis of intracellular antibodies.
pH-Activatable cell penetrating peptide dimers for potent delivery of anticancer drug to triple-negative breast cancer
We developed a pH-activatable cell-penetrating peptide dimer LH2 with histidine residues, which can penetrate cells, specifically in weak acidic conditions, even at few tens of nanomolar concentrations. LH2 effectively delivered paclitaxel into triple-negative breast cancer cells, MDA-MB-231, via formation of non-covalent complexes (PTX-LH2(M)) or covalent conjugates (PTX-LH2(C)). Moreover, LH2 showed prolonged circulation in the body and enhanced accumulation in tumors. Both PTX-LH2(M) and PTX-LH2(C) showed strong antitumor effects in a triple-negative breast cancer grafted mouse model at an extremely low dosage.
One-bead-one-compound screening approach to the identification of cyclic peptoid inhibitors of cyclophilin D as neuroprotective agents from mitochondrial dysfunction
In an effort designed to discover superior inhibitors of cyclophilin D (CypD), we identified and screened members of a one-bead-one-compound (OBOC) library of cyclic peptoid analogues of cyclosporin A (CsA). The results show that the one member of this cyclic peptoid family, I11, inhibits mitochondrial membrane potential changes mediated by CypD.
입학 및 졸업 관련양식
연구비 및 여행관련양식