교수
석차옥 Seok, Chaok
연구내용
Our ultimate goal is to understand detailed mechanisms underlying biological phenomena using computational and theoretical tools, and to contribute to curing diseases using the knowledge obtained from such studies. We are currently developing mathematical and computational techniques to model and to simulate biomolecules more efficiently and accurately. An example is an analytical loop closure method that can be used to model flexibilities in proteins loops and cyclic peptides. We will apply these methods to prediction of protein structures and biomolecular interactions, and also extend such experiences to design of new drugs and proteins.
학력
- Ph.D. Chemistry, University of Chicago, USA, 1998
- M.S. Chemistry, University of Chicago, USA, 1995
- B.S. Chemistry, Seoul National University, Korea, 1993
주요 경력
- Research Associate, University of Chicago, 1999
- Research Associate, Massachusetts Institute of Technology, 2000
- Research Associate, University of California, San Francisco, 2000-2004
주요 논문
- J. Yang, S. Kwon, S.-H. Bae, K. M. Park, C. Yoon, J.-H. Lee, and C. Seok, GalaxySagittarius: Structure- and Similarity-Based Prediction of Protein Targets for Druglike Compounds, J. Chem. Inf. Model, 60 (6), 3246-3254 (2020).
- J. Yang, M. Baek, and C. Seok, GalaxyDock3: Protein-ligand docking that considers the full ligand conformational flexibility, J. Comput. Chem. 40 (31), 2739-2748 (2019).
- J. Won, G. R. Lee, H. Park, and C. Seok, GalaxyGPCRloop: Template-Based and Ab Initio Structure Sampling of the Extracellular Loops of G-Protein-Coupled Receptors, J. Chem. Inf. Model, 58 (6), 1234-1243 (2018).
- G. R. Lee and C. Seok, Galaxy7TM: Flexible GPCR-ligand docking by structure refinement, Nucleic Acids Res. 44 (W1), W502-506 (2016).
- H. Park, H. Lee, and C. Seok, High-resolution Protein-protein Docking by Global Optimization: Recent Advances and Future Challenges, Current Opinion in Structural Biology, 35, 24-31 (2015).
- H. Lee, L. Heo, M. S. Lee, and C. Seok, GalaxyPepDock: a protein-peptide docking tool based on interaction similarity and energy optimization, Nucleic Acids Res. 43 (W1), W431-W435 (2015).
논문 검색
70. GalaxyRefine2: simultaneous refinement of inaccurate
local regions and overall protein structure
Gyu Rie Lee, Jonghun Won, Lim Heo, Chaok Seok
Seak Hee Oh, Young Hoon Sung, Inki Kim, Chan Kyu Sim, Jung Hoon Lee, Minkyung Baek, Chan-Gi Pack, Chaok Seok, Eul Ju Seo, Myeong Sup Lee, Kyung Mo Kim
Tri Duc Ngo, Changsuk Oh, Pushpak Mizar, Minkyung Baek, Kwang-su Park, Lan Nguyen, Huimyoung Byeon, Sangyoung Yoon, Yeonwoo Ryu, Bum Han Ryu, T. Doohun Kim, Jung Woon Yang, Chaok Seok, Seung Seo Lee, Kyeong Kyu Kim
Injin Bang, Hee Ryung Kim, Andrew H. Beaven, Jinuk Kim, Seung-Bum Ko, Gyu Rie Lee, Hasup Lee, Wonpil Im, Chaok Seok, Ka Young Chung, Hee-Jung Choi
Proceedings of the National Academy of Sciences of the United States of America, 2018, 115, 35, 8787-8792, (2018-08-28) Link
Chen Keasar, Liam J. McGufn, Chaok Seok, 외69명, Silvia N. Crivelli
Jonghun Won, Gyu Rie Lee, Hahnbeom Park, Chaok Seok
Gyu Rie Lee, Lim Heo, Chaok Seok
Marc F. Lensink, Sameer Velankar, Minkyung Baek, Lim Heo, Chaok Seok, Shoshana J. Wodak
Xiangqiang Shao, Hyunook Kang, Timothy Loveless, Gyu Rie Lee, Chaok Seok, William I. Weis, Hee-Jung Choi, Jeff Hardin
Qifang Xu, Qingling Tang, Panagiotis Katsonis, Olivier Lichtarge, David Jones, Samuele Bovo, Giulia Babbi, Pier L. Martelli, Rita Casadio, Gyu Rie Lee, Chaok Seok, Aron W. Fenton, Roland L. Dunbrack Jr
