교수
석차옥 Seok, Chaok
연구내용
Our ultimate goal is to understand detailed mechanisms underlying biological phenomena using computational and theoretical tools, and to contribute to curing diseases using the knowledge obtained from such studies. We are currently developing mathematical and computational techniques to model and to simulate biomolecules more efficiently and accurately. An example is an analytical loop closure method that can be used to model flexibilities in proteins loops and cyclic peptides. We will apply these methods to prediction of protein structures and biomolecular interactions, and also extend such experiences to design of new drugs and proteins.
학력
- Ph.D. Chemistry, University of Chicago, USA, 1998
- M.S. Chemistry, University of Chicago, USA, 1995
- B.S. Chemistry, Seoul National University, Korea, 1993
주요 경력
- Research Associate, University of Chicago, 1999
- Research Associate, Massachusetts Institute of Technology, 2000
- Research Associate, University of California, San Francisco, 2000-2004
주요 논문
- J. Yang, S. Kwon, S.-H. Bae, K. M. Park, C. Yoon, J.-H. Lee, and C. Seok, GalaxySagittarius: Structure- and Similarity-Based Prediction of Protein Targets for Druglike Compounds, J. Chem. Inf. Model, 60 (6), 3246-3254 (2020).
- J. Yang, M. Baek, and C. Seok, GalaxyDock3: Protein-ligand docking that considers the full ligand conformational flexibility, J. Comput. Chem. 40 (31), 2739-2748 (2019).
- J. Won, G. R. Lee, H. Park, and C. Seok, GalaxyGPCRloop: Template-Based and Ab Initio Structure Sampling of the Extracellular Loops of G-Protein-Coupled Receptors, J. Chem. Inf. Model, 58 (6), 1234-1243 (2018).
- G. R. Lee and C. Seok, Galaxy7TM: Flexible GPCR-ligand docking by structure refinement, Nucleic Acids Res. 44 (W1), W502-506 (2016).
- H. Park, H. Lee, and C. Seok, High-resolution Protein-protein Docking by Global Optimization: Recent Advances and Future Challenges, Current Opinion in Structural Biology, 35, 24-31 (2015).
- H. Lee, L. Heo, M. S. Lee, and C. Seok, GalaxyPepDock: a protein-peptide docking tool based on interaction similarity and energy optimization, Nucleic Acids Res. 43 (W1), W431-W435 (2015).
논문 검색
Florentina Tofoleanu, Juyong Lee, Frank C. Pickard IV, Gerhard König, Jing Huang, Minkyung Baek, Chaok Seok, Bernard R. Brooks
56. Absolute binding free energy calculations of CBClip host–guest systems in the SAMPL5 blind challenge
Juyong Lee, Florentina Tofoleanu, Frank C. Pickard IV, Gerhard Ko¨nig, Jing Huang, Ana Damjanovic, Minkyung Baek, Chaok Seok, Bernard R. Brooks
Gyu Rie Lee, Lim Heo, Chaok Seok
Marc F. Lensink, Sameer Velankar, Andriy Kryshtafovych, Shen-You Huang, Dina Schneidman-Duhovny, Andrej Sali, Joan Segura, Narcis Fernandez-Fuentes, Shruthi Viswanath, Ron Elber, Sergei Grudinin, Petr Popov, Emilie Neveu, Hasup Lee, Minkyung Baek, Sangwoo Park, Lim Heo, Gyu Rie Lee, Chaok Seok, Shoshana J.Wodak, 외 80명
Lim Heo, Hansup Lee, Chaok Seok
Gyu Rie Lee, Chaok Seok
Woong-Hee Shin, Gyu Rie Lee, Chaok Seok
Donghyun Ka, Hasup Lee, Yi-Deun Jung, Kyunggon Kim, Chaok Seok, Nayoung Suh, Euiyoung Bae
Hahnbeom Park, Hasup Lee, Chaok Seok
Sangwoo Lee, Woong-Hee Shin, Seongjin Hong, Habyeong Kang, Dawoon Jung, Un Hyuk Yim, Won Joon Shim, Jong Seong Khim, Chaok Seok, John P. Giesy, Kyungho Choi
