교수
석차옥 Seok, Chaok
연구내용
Our ultimate goal is to understand detailed mechanisms underlying biological phenomena using computational and theoretical tools, and to contribute to curing diseases using the knowledge obtained from such studies. We are currently developing mathematical and computational techniques to model and to simulate biomolecules more efficiently and accurately. An example is an analytical loop closure method that can be used to model flexibilities in proteins loops and cyclic peptides. We will apply these methods to prediction of protein structures and biomolecular interactions, and also extend such experiences to design of new drugs and proteins.
학력
- Ph.D. Chemistry, University of Chicago, USA, 1998
- M.S. Chemistry, University of Chicago, USA, 1995
- B.S. Chemistry, Seoul National University, Korea, 1993
주요 경력
- Research Associate, University of Chicago, 1999
- Research Associate, Massachusetts Institute of Technology, 2000
- Research Associate, University of California, San Francisco, 2000-2004
주요 논문
- J. Yang, S. Kwon, S.-H. Bae, K. M. Park, C. Yoon, J.-H. Lee, and C. Seok, GalaxySagittarius: Structure- and Similarity-Based Prediction of Protein Targets for Druglike Compounds, J. Chem. Inf. Model, 60 (6), 3246-3254 (2020).
- J. Yang, M. Baek, and C. Seok, GalaxyDock3: Protein-ligand docking that considers the full ligand conformational flexibility, J. Comput. Chem. 40 (31), 2739-2748 (2019).
- J. Won, G. R. Lee, H. Park, and C. Seok, GalaxyGPCRloop: Template-Based and Ab Initio Structure Sampling of the Extracellular Loops of G-Protein-Coupled Receptors, J. Chem. Inf. Model, 58 (6), 1234-1243 (2018).
- G. R. Lee and C. Seok, Galaxy7TM: Flexible GPCR-ligand docking by structure refinement, Nucleic Acids Res. 44 (W1), W502-506 (2016).
- H. Park, H. Lee, and C. Seok, High-resolution Protein-protein Docking by Global Optimization: Recent Advances and Future Challenges, Current Opinion in Structural Biology, 35, 24-31 (2015).
- H. Lee, L. Heo, M. S. Lee, and C. Seok, GalaxyPepDock: a protein-peptide docking tool based on interaction similarity and energy optimization, Nucleic Acids Res. 43 (W1), W431-W435 (2015).
논문 검색
Mi-Sun Kim, Hasup Lee, Lim Heo, Areum Lim, Chaok Seok, Dong Hae Shin
Lim Heo, Hahnbeom Park, Chaok Seok
Yongju Kim, Suyong Shin, Taehoon Kim, Dongseon Lee, Chaok Seok, Myongsoo Lee
Dongseon Lee, Juyong Lee, Chaok Seok
Hasup Lee, Hahnbeom Park, Junsu Ko, Chaok Seok
Woong-Hee Shin, Chaok Seok
Youn-Kyoung Lee, Juyong Lee, Jung Hyun Choi, Chaok Seok
Zhegang Huang, Seong-Kyun Kang, Motonori Banno, Tomoko Yamaguchi, Dongseon Lee, Chaok Seok, Eiji Yashima, Myongsoo Lee
29. GalaxyTBM: Template-based Modeling by Building a Reliable Core and Refining Unreliable Local Regions
Junsu Ko, Hahnbeom Park, Chaok Seok
Hahnbeom Park, Chaok Seok
