화학부교수

DEPARTMENT OF CHEMISTRY, SEOUL NATIONAL UNIVERSITY.

교수

이연 LEE, Yan

생체 재료화학 연구실
LAB Website
OFFICE 503-122 / 02-880-4344
LAB 503-101,130 / 02-880-4359

연구내용

The objectives of our research group are to understand molecular-level interactions between biological systems and external signals, to control the interactions by synthetic molecules, and to develop new artificial materials on the basis of the interactions. Especially, our group wants to develop key molecular modules for efficient penetration into biosystems, for selective response to physical, chemical, or biological signals, and for escape from severe toxicity or foreign body reactions. We wants to combine the key molecular modules for overcoming the current limitations of biomaterials in clinical applications.

학력

  • Ph. D. Chemistry, Seoul National University, Korea, 2005
  • M. S. Chemistry, Seoul National University, Korea, 2001
  • B. S. Chemistry, Seoul National University, Korea, 1999

주요 경력

  • Professor, Department of Chemistry, Seoul National University, Korea, 2022-Present
  • Associate Professor, Department of Chemistry, Seoul National University, Korea, 2014-2022
  • Assistant Professor, Department of Chemistry, Seoul National University, Korea, 2009-2014
  • Project Assistant Professor, Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, the University of Tokyo, Japan, 2008-2009.
  • Postdoctoral Fellow, Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, the University of Tokyo, Japan, 2005-2008.

주요 논문

  1. JACS Au 2021, 1, 11, 2070-2079 “Dynamics and entropy of cyclohexane rings control pH-responsive reactivity”
  2. ACS Applied Materials & Interfaces 2020, 12, 30198-30212 “Covalently grafted 2-methacryloyloxyethyl phosphorylcholine networks inhibit fibrous capsule formation around silicone breast implants in a porcine model”
  3. Chemical Communications 2019, 55, 10222-10225 “Guanidine cyclic diimides and their polymers”
  4. Advanced Science 2018, 5, 1800240 “Multimeric amphipathic α-helical sequences for rapid and efficient intracellular protein transport at nanomolar concentrations”
  5. Angewandte Chemie International Edition 2014, 53, 10086-10089 “Cell penetrating, dimeric α-helical peptides are nanomolar inhibitors of HIV-1 transcription”

논문 검색

Jinyoung Pac, Dong-Jun Koo, Hyeongjun Cho, Dongwook Jung, Min-ha Choi, Yunjung Choi, Bohyun Kim, Ji-Ung Park, Sung-Yon Kim, Yan Lee
Science advances, 2022, 8, 46, eadd9419, (2022-11-16) Link
Yuri Choi, Ji Su Park, Jinshil Kim, Kyungjin Min, Kiran Mahasenan, Choon Kim, Hye-Jin Yoon, Sewon Lim, Dae Hee Cheon, Yan Lee, Sangryeol Ryu, Shahriar Mobashery, B. Moon Kim, Hyung Ho Lee
Communications Biology, 2022, 395, 1-10, (2022-04-28) Link
Seung-No Hong, Minjae Kim, Jin-A Park, Minji Kang, Hyunkyung Cha, Sohyun Park, Joon Kon Kim, Jinyoung Pac, Yuju Seo, Sungwhan Kim, Minju Kim, Dae Woo Kim, Yan Lee
Pharmaceutics , 2022, 14, 3, 546, (2022-02-28) Link
Yumin Kim, Sangyoon Kang, Byung Hun Lee, Youngjun Song, Sunah Kang, Hye Yoon Park, Yan Lee
Chemical Science, 2022, 13, 365-372 , (2022) Link
Taeyang An, Yan Lee
Organic Letters, 2021, 23, 23, 9163-9167 , (2021-12-03) Link
Sunyoung Kang, Chanwoo Noh, Hyosik Kang, Ji-Yeon Shin, So-Young Kim, Seulah Kim, Moon-Gi Son, Eunseok Park, Hyun Kyu Song, Seokmin Shin, Sanghun Lee, Nak-Kyoon Kim, YounJoon Jung, Yan Lee
JACS Au, 2021, 1, 11, 2070-2079 , (2021-09-24) Link
Seung-Eun Chong, Donghyun Lee, Jae Hoon Oh, Sunyoung Kang, Sejong Choi, So Hee Nam, Jaehoon Yu, Heebeom Koo, Yan Lee
Biomaterials Science, 2021, 9, 7826-7831 , (2021-08-12) Link
Sunah Kang, Sohyun Park, Hojoon Song, Dongkil Choi, Han-Eol Park, Benjamin H. Ahn, Sung-Yon Kim, Yan Lee
ACS Applied Materials & Interfaces, 2021, 13, 24, 28962-28974, (2021-06-10) Link
Gyu Chan Kim, Dae Hee Cheon, Yan Lee
Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2021, 1869, 4, 140604, (2021-03-25) Link
Seung-Eun Chong, Jae Hoon Oh, Kyungjin Min, Sohyun Park, Sejong Choi, Joon Hyung Ahn, Dahyun Chun, Hyung Ho Lee, Jaehoon Yu, Yan Lee
Journal of Controlled Release, 2021, 330, 161-172, (2021-02-10) Link