교수
박승범 Park, Seung Bum
화학생물학연구실
LAB Website
LAB Website
OFFICE
503-522
/
02-880-9090
LAB
503-508,530
/
02-880-4373
E-MAIL sbpark@snu.ac.kr
연구내용
The main focus of my research is the identification and development of new bioactive chemical properties, which allow us to study the complex biological system as well as to utilize the new properties as potential therapeutic agents (drugs), through interdisciplinary approaches; Organic Chemistry, Bioassay, and Chemical Biology.
Design and synthesis of diverse and complex small molecules through Diversity Oriented Synthesis (DOS)
Development of new high-throughput screening for biological evaluation
Chemical Biology for the Application of identified bioactive small molecules
Design and synthesis of diverse and complex small molecules through Diversity Oriented Synthesis (DOS)
Development of new high-throughput screening for biological evaluation
Chemical Biology for the Application of identified bioactive small molecules
학력
- Ph.D. Chemistry, Texas A＆M University, USA, 2001
- M.S. Chemistry, Yonsei University, Korea, 1997
- B.S. Chemistry, Yonsei University, Korea, 1993
주요 경력
- Postdoctoral Research Fellow, Harvard University, 2001-2004
주요 논문
- “Phenotypic Discovery of Neuroprotective Agents by Regulation of Tau Proteostasis via Stress‐Responsive Activation of PERK Signaling.” Shin, Y.-H.; Cho, H.; Choi, B.Y.; Ha, J.; Kim, J.; Yim, J.; Suh, S.W.; Park, S.B.* Angew. Chem. Int. Ed., 2021 (DOI: 10.1002/anie.202013915) (Cover article).
- “Nature-inspired remodeling of (aza)indoles to meta-aminoaryl nicotinates for late-stage conjugation of vitamin B3 to (hetero)arylamines.” Varun, B.V.†; Vaithegi, K.†; Yi, S.; Park, S.B.* Nature Communications, 2020, 11: 6308.
- “Monochromophoric Design Strategy for Tetrazine-based Colorful Bioorthogonal Probes with a Single Fluorescent Core Skeleton.” Lee, Y.; Cho, W.; Sung, J.; Kim, E.*; Park, S. B.* J. Am. Chem. Soc., 2018, 140, 974–983 (Cover article).
- “Diversity-Oriented Synthetic Strategy for Developing Chemical Modulator of Protein–Protein Interaction.” Kim, J.; Koo, J.; Jung, J.; Cho, W.; Lee, W. S.; Kim, C.; Park, W.; Park, S.B.* Nature Communications, 2016, 7: 13196.
- “Discovery, Understanding, and Bioapplication of Organic Fluorophore: A Case Study with an Indolizine-Based Novel Fluorophore, Seoul-Fluor.” Kim, E.; Lee, Y.; Lee, S.; Park, S.B.* Acc. Chem. Res. 2015, 48(3), 538–547.
- “A Small Molecule Binding HMGB1 and HMGB2 Inhibits Microglia-Mediated Neuroinflammation.” Lee, S.; Nam, Y.; Koo, J.Y.; Lim, D.; Park, J.; Ock, J.; Suk, K.*; Park, S.B.* Nature Chemical Biology 2014 10(12), 1055–1060.
논문 검색
Dahham Kim, Hayoung Son, Seung Bum Park
Hana Cho, Bo Young Choi, Young-Hee Shin, Sang Won Suh, Seung Bum Park
Wansang Cho, Jung Ho Lee, Seung Bum Park
Kannan Vaithegi, Sihyeong Yi, Ji Hyae Lee, Begur Vasanthkumar Varun, Seung Bum Park
Dr. Wansang Cho, Solchan Won, Dr. Yoona Choi, Dr. Sihyeong Yi, Jong Beom Park, Dr. Jun-Gyu Park, Caroline E. Kim, Dr. Chintam Narayana, Ju Hee Kim, Dr. Junhyeong Yim, Dr. Young Il Choi, Prof. Dong-Sup Lee, Seung Bum Park
Si-jie Dai, Yu-ying Shao, Yang Zheng, Jin-yi Sun, Zhi-sheng Li, Jia-ying Shi, Meng-qi Yan, Xiao-yun Qiu, Ceng-lin Xu, Wan-sang Cho, Masahiro Nishibori, Sihyeong Yi, Seung Bum Park, Yi Wang, Zhong Chen
Jinjoo Jung, Jongbeom Park, Mingi Kim, Jaeyoung Ha, Hana Cho, Seung Bum Park
Junhyeong Yim, Jaeseok Lee, Sihyeong Yi, Ja Young Koo, Sangmi Oh, Hankum Park, Seong Soon Kim, Myung Ae Bae, Jongmin Park, Seung Bum Park
Jesang Lee, Seung Bum Park
Hyun-Jin Jang, Yae Jin Yoon, Jiyeon Choi, Yu-Jin Lee, Sangku Lee, Wansang Cho, Wan Gi Byun, Seung Bum Park, Dong Cho Han, Byoung-Mog Kwon
