교수
박승범 Park, Seung Bum
화학생물학연구실
LAB Website
LAB Website
OFFICE
503-522
/
02-880-9090
LAB
503-508,530
/
02-880-4373
E-MAIL sbpark@snu.ac.kr
연구내용
The main focus of my research is the identification and development of new bioactive chemical properties, which allow us to study the complex biological system as well as to utilize the new properties as potential therapeutic agents (drugs), through interdisciplinary approaches; Organic Chemistry, Bioassay, and Chemical Biology.
Design and synthesis of diverse and complex small molecules through Diversity Oriented Synthesis (DOS)
Development of new high-throughput screening for biological evaluation
Chemical Biology for the Application of identified bioactive small molecules
Design and synthesis of diverse and complex small molecules through Diversity Oriented Synthesis (DOS)
Development of new high-throughput screening for biological evaluation
Chemical Biology for the Application of identified bioactive small molecules
학력
- Ph.D. Chemistry, Texas A＆M University, USA, 2001
- M.S. Chemistry, Yonsei University, Korea, 1997
- B.S. Chemistry, Yonsei University, Korea, 1993
주요 경력
- Postdoctoral Research Fellow, Harvard University, 2001-2004
주요 논문
- “Phenotypic Discovery of Neuroprotective Agents by Regulation of Tau Proteostasis via Stress‐Responsive Activation of PERK Signaling.” Shin, Y.-H.; Cho, H.; Choi, B.Y.; Ha, J.; Kim, J.; Yim, J.; Suh, S.W.; Park, S.B.* Angew. Chem. Int. Ed., 2021 (DOI: 10.1002/anie.202013915) (Cover article).
- “Nature-inspired remodeling of (aza)indoles to meta-aminoaryl nicotinates for late-stage conjugation of vitamin B3 to (hetero)arylamines.” Varun, B.V.†; Vaithegi, K.†; Yi, S.; Park, S.B.* Nature Communications, 2020, 11: 6308.
- “Monochromophoric Design Strategy for Tetrazine-based Colorful Bioorthogonal Probes with a Single Fluorescent Core Skeleton.” Lee, Y.; Cho, W.; Sung, J.; Kim, E.*; Park, S. B.* J. Am. Chem. Soc., 2018, 140, 974–983 (Cover article).
- “Diversity-Oriented Synthetic Strategy for Developing Chemical Modulator of Protein–Protein Interaction.” Kim, J.; Koo, J.; Jung, J.; Cho, W.; Lee, W. S.; Kim, C.; Park, W.; Park, S.B.* Nature Communications, 2016, 7: 13196.
- “Discovery, Understanding, and Bioapplication of Organic Fluorophore: A Case Study with an Indolizine-Based Novel Fluorophore, Seoul-Fluor.” Kim, E.; Lee, Y.; Lee, S.; Park, S.B.* Acc. Chem. Res. 2015, 48(3), 538–547.
- “A Small Molecule Binding HMGB1 and HMGB2 Inhibits Microglia-Mediated Neuroinflammation.” Lee, S.; Nam, Y.; Koo, J.Y.; Lim, D.; Park, J.; Ock, J.; Suk, K.*; Park, S.B.* Nature Chemical Biology 2014 10(12), 1055–1060.
논문 검색
Jun Seo Park, Kwang Hwan Kim, Hye Won Jun, Se-Young Choi, Seung Bum Park, Sung Joong Lee
Wan Gi Byun, Sumin Son, JinAh Lee, Minha Lee, Meehyun Ko, Songrui Zhao, Ju Hee Kim, Kannan Vaithegi, Ji Hoon Kwon, Jung Ho Lee, Sangeun Jeon, Dawon Yi, Peng Zou, Seungtaek Kim, Seung Bum Park
185. Human gut bacteria produce structurally related monoglycolipids with contrasting immune functions
Ji-Sun Yoo, Da-Jung Jung, Byoungsook Goh, Kyoo Heo, Wen Zheng, ChangWon C. Lee, Jeong In Seo, Naama Geva-Zatorsky, Meng Wu, Seung Bum Park, Dennis L. Kasper, Sungwhan F. Oh
Sihyeong Yi, Ji Hyae Lee, Seung Bum Park
Ji Hyae Lee, Sihyeong Yi, Juhyun Bang, Hyun Choi, Seung Bum Park
Hyoung-Soo Cho, Ji-Sun Yoo, Xinyang Song, Byoungsook Goh, Alos Diallo, Jesang Lee, Sumin Son, Yoon Soo Hwang, Seung Bum Park, Sungwhan F. Oh, Dennis L. Kasper
Hayoung Son, Dahham Kim, Sohee Kim, Wan Gi Byun, Seung Bum Park
Jesang Lee, Sumin Son, Minha Lee, Seung Bum Park
Jeong Yeon Yoo, Chanwoo Kim, Ji Hoon Kwon, Hana Cho, Kiyoung Jeong, Wonwoo Park, Younghun Kim, Dongwhan Lee, Seung Bum Park
Sihyeong Yi, Dahham Kim, Wansang Cho, Jung Ho Lee, Ji Hoon Kwon, Jonghoon Kim, Seung Bum Park
