교수
박승범 Park, Seung Bum
화학생물학연구실
LAB Website
LAB Website
OFFICE
503-522
/
02-880-9090
LAB
503-508,530
/
02-880-4373
E-MAIL sbpark@snu.ac.kr
연구내용
The main focus of my research is the identification and development of new bioactive chemical properties, which allow us to study the complex biological system as well as to utilize the new properties as potential therapeutic agents (drugs), through interdisciplinary approaches; Organic Chemistry, Bioassay, and Chemical Biology.
Design and synthesis of diverse and complex small molecules through Diversity Oriented Synthesis (DOS)
Development of new high-throughput screening for biological evaluation
Chemical Biology for the Application of identified bioactive small molecules
Design and synthesis of diverse and complex small molecules through Diversity Oriented Synthesis (DOS)
Development of new high-throughput screening for biological evaluation
Chemical Biology for the Application of identified bioactive small molecules
학력
- Ph.D. Chemistry, Texas A＆M University, USA, 2001
- M.S. Chemistry, Yonsei University, Korea, 1997
- B.S. Chemistry, Yonsei University, Korea, 1993
주요 경력
- Postdoctoral Research Fellow, Harvard University, 2001-2004
주요 논문
- “Phenotypic Discovery of Neuroprotective Agents by Regulation of Tau Proteostasis via Stress‐Responsive Activation of PERK Signaling.” Shin, Y.-H.; Cho, H.; Choi, B.Y.; Ha, J.; Kim, J.; Yim, J.; Suh, S.W.; Park, S.B.* Angew. Chem. Int. Ed., 2021 (DOI: 10.1002/anie.202013915) (Cover article).
- “Nature-inspired remodeling of (aza)indoles to meta-aminoaryl nicotinates for late-stage conjugation of vitamin B3 to (hetero)arylamines.” Varun, B.V.†; Vaithegi, K.†; Yi, S.; Park, S.B.* Nature Communications, 2020, 11: 6308.
- “Monochromophoric Design Strategy for Tetrazine-based Colorful Bioorthogonal Probes with a Single Fluorescent Core Skeleton.” Lee, Y.; Cho, W.; Sung, J.; Kim, E.*; Park, S. B.* J. Am. Chem. Soc., 2018, 140, 974–983 (Cover article).
- “Diversity-Oriented Synthetic Strategy for Developing Chemical Modulator of Protein–Protein Interaction.” Kim, J.; Koo, J.; Jung, J.; Cho, W.; Lee, W. S.; Kim, C.; Park, W.; Park, S.B.* Nature Communications, 2016, 7: 13196.
- “Discovery, Understanding, and Bioapplication of Organic Fluorophore: A Case Study with an Indolizine-Based Novel Fluorophore, Seoul-Fluor.” Kim, E.; Lee, Y.; Lee, S.; Park, S.B.* Acc. Chem. Res. 2015, 48(3), 538–547.
- “A Small Molecule Binding HMGB1 and HMGB2 Inhibits Microglia-Mediated Neuroinflammation.” Lee, S.; Nam, Y.; Koo, J.Y.; Lim, D.; Park, J.; Ock, J.; Suk, K.*; Park, S.B.* Nature Chemical Biology 2014 10(12), 1055–1060.
논문 검색
Yun Lim Jung, Sourav Sarkar, Jaeyoung Ha, Seung Bum Park, Kyo Han Ahn
Wan Gi Byun, Donghyun Lim, Seung Bum Park
Youngjun Lee, Dahham Kim, Seung Bum Park
Yoona Choi, Subin Lee, Heejun Kim, Seung Bum Park
Young-Hee Shin, Kiyoung Jeong, Jihye Lee, Hyo Jung Lee, Junhyeong Yim, Jonghoon Kim, Seungtaek Kim, Seung Bum Park
Sungwhan F. Oh, T. Praveena, Heebum Song, Ji-Sun Yoo, Da-Jung Jung, Deniz Erturk-Hasdemir, Yoon Soo Hwang, ChangWon C. Lee, Jérôme Le Nours, Hyunsoo Kim, Jesang Lee, Richard S. Blumberg, Jamie Rossjohn, Seung Bum Park, Dennis L. Kasper
Wan Gi Byun, Jihye Lee, Seungtaek Kim, Seung Bum Park
Jaeyoung Ha, Seung Bum Park
Hyunsoo Kim, Yoon Soo Hwang, Mingi Kim, Seung Bum Park
