화학부교수

DEPARTMENT OF CHEMISTRY, SEOUL NATIONAL UNIVERSITY.

교수

이남기 Lee, Nam Ki

단일 분자 및 세포 동역학 연구실
LAB Website
OFFICE 503-423 / 02-880-2234
LAB 503-403,132 / 02-880-2235
RESEARCH AREAS

연구내용

The main research interest of our group is developing new single-molecule and single-cell imaging techniques for investigating various biological phenomena. We are using single-molecule FRET, single-vesicle assay, single-protein detection in a living cell, real-time single-protein tracking, and super-resolution imaging. Using these techniques, we are directly visualizing the cellular processes, such as transcriptional dynamics and the movement of DNA, in a living cell. We are also heavily investigating membrane protein interactions and their diffusional mode in a living cell. Not only the living cell system, we are also studying protein-DNA interactions at the single-molecule level. Finally, we are studying the molecular mechanism of Parkinson’s disease based on the interactions between alpha-Synuclein and SNARE-proteins

학력

  • Ph.D. Chemistry, Seoul National University, Seoul, Korea, 2005
  • M.S. Chemistry, Seoul National University, Seoul, Korea, 2000
  • B.S. Chemistry, Seoul National University, Seoul, Korea, 1998

주요 경력

  • Associate Professor, Department of Chemistry, Seoul National University, Seoul, Korea, 2017-Present
  • Associate Professor, Department of Physics & School of Interdisciplinary Bioscience and Bioengineering, Pohang University of Science and Technology (POSTECH), Pohang, Korea, 2013-2017
  • Assistant Professor, Department of Physics & School of Interdisciplinary Bioscience and Bioengineering, Pohang University of Science and Technology (POSTECH), Pohang, Korea, 2009-2013
  • Postdoctoral Fellow, Harvard University, Cambridge, USA, 2006-2008
  • Visiting Scientist, U. C. Los Angeles, California, USA, 2002-2003

주요 논문

  1. "Single-molecule observation of ATP-independent SSB displacement by RecO in Deinococcus radiodurans", J. Hwang, J.-Y. Kim, C. Kim, S. park, S. Joo, S. K. Kim*, N. K. Lee*, eLife, 2020, 9, e50945.
  2. "Transcription and translation contribute to gene locus relocation to the nucleoid periphery in E.coli.” S. Yang, S. H. Kim, D.-K. Kim, H. J. An, J. B. Son, A. H. Gynnå, N. K. Lee, Nat. Commun. 2019, 10, 5131.
  3. “Dynamic release of bending stress in short dsDNA by a kink and forks”, C. Kim, O. Lee, J.-Y. Kim, W. Sung, N. K. Lee, Angew. Chem. Int. Ed. 2015, 31, 8943-8947.
  4. “Real-time submillisecond single-molecule FRET dynamics of freely diffusing molecules with liposome tethering”, J.-Y. Kim, C. Kim, N. K. Lee, Nat. Commun. 2015, 6, 6992.
  5. “Contribution of RNA polymerase concentration variation to protein expression noise”, S. Yang, S. H. Kim, Y. R. Lim, C. H. Kim, H. J. An, J-H Kim, J. Sung,* N. K Lee*, Nat. Commun. 2014, 5, 4761.
  6. “Large α-Synuclein oligomers inhibit neuronal SNARE-mediated vesicle docking”, B. K Choi, M. G. Choi, J. Y. Kim, Y. Yang, Y. Lai, D. H. Kweon, N. K. Lee,* Y. K. Shin*, Proc. Natl. Acad. Sci. USA 2013, 110, 4087-4092.

논문 검색

Jaehun Yi, Sanghun Yeou, Nam Ki Lee
Journal of the American Chemical Society, 2022, 144, 29, 13137–13145, (2022-07-27) Link
Sanghun Yeou, Jihee Hwang, Jaehun Yi, Cheolhee Kim, Seong Keun Kim, Nam Ki Lee
Chemical Science, 2022, 13, 7516-7525, (2022-06-02) Link
Sanghun Yeou, Nam Ki Lee
Molecules and Cells, 2022, 45, 1, 33-40, (2022-03-31) Link
Dong-Kyun Kim, Young Sook Kim, Chan Sik Kim, Nam Ki Lee
Bulletin of the Korean Chemical Society, 2021, 42, 3, 393–397 , (20210301) Link
Yoonjung Cho, Hyeong Jeon An, Taehoon Kim, Chulbom Lee, Nam Ki Lee
Journal of the American Chemical Society, 2021, 143, 35, 14125–14135, (2021-09-08) Link
Sanghun Yeou, Nam Ki Lee
Bulletin of the Korean Chemical Society, 2021, 42, 8, 1151-1154, (2021-08) Link
Ryan Khounlo, Brenden J. D. Hawk, Tung-Mei Khu, Gyeongji Yoo, Nam Ki Lee, Josh Pierson, Yeon-Kyun Shin
Frontiers in Cell and Developmental Biology, 2021, 9, 663431, (2021-07-19) Link
Eitan Lerner, Anders Barth, Jelle Hendrix, Benjamin Ambrose, Victoria Birkedal, Scott C Blanchard, Richard Börner, Hoi Sung Chung, Thorben Cordes, Timothy D Craggs, Ashok A Deniz, Jiajie Diao, Jingyi Fei, Ruben L Gonzalez, Irina V Gopich, Taekjip Ha, Christian A Hanke, Gilad Haran, Nikos S Hatzakis, Sungchul Hohng, Seok-Cheol Hong, Thorsten Hugel, Antonino Ingargiola, Chirlmin Joo, Achillefs N Kapanidis, Harold D Kim, Ted Laurence, Nam Ki Lee, Tae-Hee Lee, Edward A Lemke, Emmanuel Margeat, Jens Michaelis, Xavier Michalet, Sua Myong, Daniel Nettels, Thomas-Otavio Peulen, Evelyn Ploetz, Yair Razvag, Nicole C Robb, Benjamin Schuler, Hamid Soleimaninejad, Chun Tang, Reza Vafabakhsh, Don C Lamb, Claus Am Seidel, Shimon Weiss
eLife, 2021, 10, e60416, 1-69, (2021-05-29) Link
Gyeongji Yoo, Sanghun Yeou, Jung Bae Son, Yeon-Kyun Shin, Nam Ki Lee
Scientific Reports, 2021, 11, 10955, 1-12, (2021-05-26) Link
Jihee Hwang, Jae-Yeol Kim, Cheolhee Kim, Soojin Park, Sungmin Joo, Seong Keun Kim, Nam Ki Lee
eLife, 2020, 9, e50945-e50945, (2020-04-16) Link