화학부교수

DEPARTMENT OF CHEMISTRY, SEOUL NATIONAL UNIVERSITY.

교수

이남기 Lee, Nam Ki

단일 분자 및 세포 동역학 연구실
LAB Website
OFFICE 503동 423호 / 02-880-2234
LAB 503-403,132 / 02-880-2235
RESEARCH AREAS

연구내용

The main research interest of our group is developing new single-molecule and single-cell imaging techniques for investigating various biological phenomena. We are using single-molecule FRET, single-vesicle assay, single-protein detection in a living cell, real-time single-protein tracking, and super-resolution imaging. Using these techniques, we are directly visualizing the cellular processes, such as transcriptional dynamics and the movement of DNA, in a living cell. We are also heavily investigating membrane protein interactions and their diffusional mode in a living cell. Not only the living cell system, we are also studying protein-DNA interactions at the single-molecule level. Finally, we are studying the molecular mechanism of Parkinson’s disease based on the interactions between alpha-Synuclein and SNARE-proteins

학력

  • Ph.D. Chemistry, Seoul National University, Seoul, Korea, 2005
  • M.S. Chemistry, Seoul National University, Seoul, Korea, 2000
  • B.S. Chemistry, Seoul National University, Seoul, Korea, 1998

주요 경력

  • Associate Professor, Department of Chemistry, Seoul National University, Seoul, Korea, 2017-Present
  • Associate Professor, Department of Physics & School of Interdisciplinary Bioscience and Bioengineering, Pohang University of Science and Technology (POSTECH), Pohang, Korea, 2013-2017
  • Assistant Professor, Department of Physics & School of Interdisciplinary Bioscience and Bioengineering, Pohang University of Science and Technology (POSTECH), Pohang, Korea, 2009-2013
  • Postdoctoral Fellow, Harvard University, Cambridge, USA, 2006-2008
  • Visiting Scientist, U. C. Los Angeles, California, USA, 2002-2003

주요 논문

  1. "Single-molecule observation of ATP-independent SSB displacement by RecO in Deinococcus radiodurans", J. Hwang, J.-Y. Kim, C. Kim, S. park, S. Joo, S. K. Kim*, N. K. Lee*, eLife, 2020, 9, e50945.
  2. "Transcription and translation contribute to gene locus relocation to the nucleoid periphery in E.coli.” S. Yang, S. H. Kim, D.-K. Kim, H. J. An, J. B. Son, A. H. Gynnå, N. K. Lee, Nat. Commun. 2019, 10, 5131.
  3. “Dynamic release of bending stress in short dsDNA by a kink and forks”, C. Kim, O. Lee, J.-Y. Kim, W. Sung, N. K. Lee, Angew. Chem. Int. Ed. 2015, 31, 8943-8947.
  4. “Real-time submillisecond single-molecule FRET dynamics of freely diffusing molecules with liposome tethering”, J.-Y. Kim, C. Kim, N. K. Lee, Nat. Commun. 2015, 6, 6992.
  5. “Contribution of RNA polymerase concentration variation to protein expression noise”, S. Yang, S. H. Kim, Y. R. Lim, C. H. Kim, H. J. An, J-H Kim, J. Sung,* N. K Lee*, Nat. Commun. 2014, 5, 4761.
  6. “Large α-Synuclein oligomers inhibit neuronal SNARE-mediated vesicle docking”, B. K Choi, M. G. Choi, J. Y. Kim, Y. Yang, Y. Lai, D. H. Kweon, N. K. Lee,* Y. K. Shin*, Proc. Natl. Acad. Sci. USA 2013, 110, 4087-4092.

논문 검색

Jung Bae Son, Seunghyeon Kim, Sora Yang, Youmin Ahn, Nam Ki Lee
The Journal of Physical Chemistry B, 2024, 128, 28, 6730-6741, (2024-07-18) Link
Taekjip Ha, Jingyi Fei, Sonja Schmid, Nam Ki Lee, Ruben L. Gonzalez Jr, Sneha Paul, Sanghun Yeou
Nature Reviews Methods Primers, 2024, 4, 1, 21, (2024-03-28) Link
Younghun Kim, Heechan Kim, Jung Bae Son, Michael Filatov, Cheol Ho Choi, Nam Ki Lee, Dongwhan Lee
Angewandte Chemie International Edition, 2023, 62, 29, e202302107, (2023-05-08) Link
Gyeongji Yoo, Yeon-Kyun Shin, Nam Ki Lee
Journal of Molecular Biology, 2023, 435, 1, 167775, (2023-01-15) Link
Gyeongji Yoo, Hyeong Jeon An, Sanghun Yeou, Nam Ki Lee
Molecules and Cells, 2022, 45, 11, 806-819, (2022-11-16) Link
Jaehun Yi, Sanghun Yeou, Nam Ki Lee
Journal of the American Chemical Society, 2022, 144, 29, 13137–13145, (2022-07-27) Link
Sanghun Yeou, Jihee Hwang, Jaehun Yi, Cheolhee Kim, Seong Keun Kim, Nam Ki Lee
Chemical Science, 2022, 13, 7516-7525, (2022-06-02) Link
Sanghun Yeou, Nam Ki Lee
Molecules and Cells, 2022, 45, 1, 33-40, (2022-03-31) Link
Dong-Kyun Kim, Young Sook Kim, Chan Sik Kim, Nam Ki Lee
Bulletin of the Korean Chemical Society, 2021, 42, 3, 393–397 , (20210301) Link
Yoonjung Cho, Hyeong Jeon An, Taehoon Kim, Chulbom Lee, Nam Ki Lee
Journal of the American Chemical Society, 2021, 143, 35, 14125–14135, (2021-09-08) Link