교수
이남기 Lee, Nam Ki
단일 분자 및 세포 동역학 연구실
LAB Website
LAB Website
OFFICE
503동 423호
/
02-880-2234
LAB
503-403,132
/
02-880-2235
E-MAIL namkilee@snu.ac.kr
연구내용
The main research interest of our group is developing new single-molecule and single-cell imaging techniques for investigating various biological phenomena. We are using single-molecule FRET, single-vesicle assay, single-protein detection in a living cell, real-time single-protein tracking, and super-resolution imaging. Using these techniques, we are directly visualizing the cellular processes, such as transcriptional dynamics and the movement of DNA, in a living cell. We are also heavily investigating membrane protein interactions and their diffusional mode in a living cell. Not only the living cell system, we are also studying protein-DNA interactions at the single-molecule level. Finally, we are studying the molecular mechanism of Parkinson’s disease based on the interactions between alpha-Synuclein and SNARE-proteins
학력
- Ph.D. Chemistry, Seoul National University, Seoul, Korea, 2005
- M.S. Chemistry, Seoul National University, Seoul, Korea, 2000
- B.S. Chemistry, Seoul National University, Seoul, Korea, 1998
주요 경력
- Associate Professor, Department of Chemistry, Seoul National University, Seoul, Korea, 2017-Present
- Associate Professor, Department of Physics & School of Interdisciplinary Bioscience and Bioengineering, Pohang University of Science and Technology (POSTECH), Pohang, Korea, 2013-2017
- Assistant Professor, Department of Physics & School of Interdisciplinary Bioscience and Bioengineering, Pohang University of Science and Technology (POSTECH), Pohang, Korea, 2009-2013
- Postdoctoral Fellow, Harvard University, Cambridge, USA, 2006-2008
- Visiting Scientist, U. C. Los Angeles, California, USA, 2002-2003
주요 논문
- "Single-molecule observation of ATP-independent SSB displacement by RecO in Deinococcus radiodurans", J. Hwang, J.-Y. Kim, C. Kim, S. park, S. Joo, S. K. Kim*, N. K. Lee*, eLife, 2020, 9, e50945.
- "Transcription and translation contribute to gene locus relocation to the nucleoid periphery in E.coli.” S. Yang, S. H. Kim, D.-K. Kim, H. J. An, J. B. Son, A. H. Gynnå, N. K. Lee, Nat. Commun. 2019, 10, 5131.
- “Dynamic release of bending stress in short dsDNA by a kink and forks”, C. Kim, O. Lee, J.-Y. Kim, W. Sung, N. K. Lee, Angew. Chem. Int. Ed. 2015, 31, 8943-8947.
- “Real-time submillisecond single-molecule FRET dynamics of freely diffusing molecules with liposome tethering”, J.-Y. Kim, C. Kim, N. K. Lee, Nat. Commun. 2015, 6, 6992.
- “Contribution of RNA polymerase concentration variation to protein expression noise”, S. Yang, S. H. Kim, Y. R. Lim, C. H. Kim, H. J. An, J-H Kim, J. Sung,* N. K Lee*, Nat. Commun. 2014, 5, 4761.
- “Large α-Synuclein oligomers inhibit neuronal SNARE-mediated vesicle docking”, B. K Choi, M. G. Choi, J. Y. Kim, Y. Yang, Y. Lai, D. H. Kweon, N. K. Lee,* Y. K. Shin*, Proc. Natl. Acad. Sci. USA 2013, 110, 4087-4092.
논문 검색
Jung Bae Son, Seunghyeon Kim, Sora Yang, Youmin Ahn, Nam Ki Lee
Taekjip Ha, Jingyi Fei, Sonja Schmid, Nam Ki Lee, Ruben L. Gonzalez Jr, Sneha Paul, Sanghun Yeou
Younghun Kim, Heechan Kim, Jung Bae Son, Michael Filatov, Cheol Ho Choi, Nam Ki Lee, Dongwhan Lee
Gyeongji Yoo, Yeon-Kyun Shin, Nam Ki Lee
Gyeongji Yoo, Hyeong Jeon An, Sanghun Yeou, Nam Ki Lee
Jaehun Yi, Sanghun Yeou, Nam Ki Lee
Sanghun Yeou, Jihee Hwang, Jaehun Yi, Cheolhee Kim, Seong Keun Kim, Nam Ki Lee
Sanghun Yeou, Nam Ki Lee
23. Method for the Rapid Screening of Drug Candidates Using Single-Protein Tracking in a Living Cell
Dong-Kyun Kim, Young Sook Kim, Chan Sik Kim, Nam Ki Lee
Yoonjung Cho, Hyeong Jeon An, Taehoon Kim, Chulbom Lee, Nam Ki Lee