Professor
Park, Seung Bum
Chemical Biology Laboratory
LAB Website
LAB Website
OFFICE
503-522
/
+82-2-880-9090
LAB
503-508,530
/
+82-2-880-4373
E-MAIL sbpark@snu.ac.kr
Research Topic
The main focus of my research is the identification and development of new bioactive chemical properties, which allow us to study the complex biological system as well as to utilize the new properties as potential therapeutic agents (drugs), through interdisciplinary approaches; Organic Chemistry, Bioassay, and Chemical Biology.
Design and synthesis of diverse and complex small molecules through Diversity Oriented Synthesis (DOS)
Development of new high-throughput screening for biological evaluation
Chemical Biology for the Application of identified bioactive small molecules
Design and synthesis of diverse and complex small molecules through Diversity Oriented Synthesis (DOS)
Development of new high-throughput screening for biological evaluation
Chemical Biology for the Application of identified bioactive small molecules
Education
- Ph.D. Chemistry, Texas A&M University, USA, 2001
- M.S. Chemistry, Yonsei University, Korea, 1997
- B.S. Chemistry, Yonsei University, Korea, 1993
Career
- Postdoctoral Research Fellow, Harvard University, 2001-2004
Papers
- “Phenotypic Discovery of Neuroprotective Agents by Regulation of Tau Proteostasis via Stress‐Responsive Activation of PERK Signaling.” Shin, Y.-H.; Cho, H.; Choi, B.Y.; Ha, J.; Kim, J.; Yim, J.; Suh, S.W.; Park, S.B.* Angew. Chem. Int. Ed., 2021 (DOI: 10.1002/anie.202013915) (Cover article).
- “Nature-inspired remodeling of (aza)indoles to meta-aminoaryl nicotinates for late-stage conjugation of vitamin B3 to (hetero)arylamines.” Varun, B.V.†; Vaithegi, K.†; Yi, S.; Park, S.B.* Nature Communications, 2020, 11: 6308.
- “Monochromophoric Design Strategy for Tetrazine-based Colorful Bioorthogonal Probes with a Single Fluorescent Core Skeleton.” Lee, Y.; Cho, W.; Sung, J.; Kim, E.*; Park, S. B.* J. Am. Chem. Soc., 2018, 140, 974–983 (Cover article).
- “Diversity-Oriented Synthetic Strategy for Developing Chemical Modulator of Protein–Protein Interaction.” Kim, J.; Koo, J.; Jung, J.; Cho, W.; Lee, W. S.; Kim, C.; Park, W.; Park, S.B.* Nature Communications, 2016, 7: 13196.
- “Discovery, Understanding, and Bioapplication of Organic Fluorophore: A Case Study with an Indolizine-Based Novel Fluorophore, Seoul-Fluor.” Kim, E.; Lee, Y.; Lee, S.; Park, S.B.* Acc. Chem. Res. 2015, 48(3), 538–547.
- “A Small Molecule Binding HMGB1 and HMGB2 Inhibits Microglia-Mediated Neuroinflammation.” Lee, S.; Nam, Y.; Koo, J.Y.; Lim, D.; Park, J.; Ock, J.; Suk, K.*; Park, S.B.* Nature Chemical Biology 2014 10(12), 1055–1060.
Search Papers
Min Chul Shin, Youngjun Lee, Seung Bum Park, Eunha Kim
Hyunsoo Kim, Ala Jo, Sun-Sil Choi, Hyunsung Nam, WanGi Byun, HwanBae, Jang Hyun Choi, Seung Bum Park
Sanghee Lee, Wansang Cho, Sungyoul Hong, Sihyeong Yi, Heejun Kim, Soo Yeon Baek, Hankum Park, Jinjoo Jung, Young Kee Shin, Seung Bum Park
JunYoung Jang, Hyunsoo Kim, Hyun-Jung Kim, Se Won Suh, Seung Bum Park, ByungWoo Han
Hankum Park, Jaeyoung Ha, Seung Bum Park
140. Development of α‑GalCer Analogues with an α‑Fluorocarbonyl
Moiety as Th2-Selective Ligands of CD1d
Hyunsoo Kim, Heebum Song, Jun-Gyu Park, Dong-Sup Lee, Seung Bum Park
139. Improved Th17 Selectivity of α‑Galactosylceramide via Noncovalent
Interactions with Diether Moiety
Yoon Soo Hwang, Junhyeong Yim, Heebum Song, Seung Bum Park
Hankum Park, Seung Bum Park
Hwan Hee Lee, So Hee Im, Sunjoo Ahn, Myung Ae Bae, Seung Bum Park, Sang Kyum Kim, Jin Sook Song
Andrea Basso, Seung Bum Park, Lisa Moni