Professor
Park, Seung Bum
Chemical Biology Laboratory
LAB Website
LAB Website
OFFICE
503-522
/
+82-2-880-9090
LAB
503-508,530
/
+82-2-880-4373
E-MAIL sbpark@snu.ac.kr
Research Topic
The main focus of my research is the identification and development of new bioactive chemical properties, which allow us to study the complex biological system as well as to utilize the new properties as potential therapeutic agents (drugs), through interdisciplinary approaches; Organic Chemistry, Bioassay, and Chemical Biology.
Design and synthesis of diverse and complex small molecules through Diversity Oriented Synthesis (DOS)
Development of new high-throughput screening for biological evaluation
Chemical Biology for the Application of identified bioactive small molecules
Design and synthesis of diverse and complex small molecules through Diversity Oriented Synthesis (DOS)
Development of new high-throughput screening for biological evaluation
Chemical Biology for the Application of identified bioactive small molecules
Education
- Ph.D. Chemistry, Texas A&M University, USA, 2001
- M.S. Chemistry, Yonsei University, Korea, 1997
- B.S. Chemistry, Yonsei University, Korea, 1993
Career
- Postdoctoral Research Fellow, Harvard University, 2001-2004
Papers
- “Phenotypic Discovery of Neuroprotective Agents by Regulation of Tau Proteostasis via Stress‐Responsive Activation of PERK Signaling.” Shin, Y.-H.; Cho, H.; Choi, B.Y.; Ha, J.; Kim, J.; Yim, J.; Suh, S.W.; Park, S.B.* Angew. Chem. Int. Ed., 2021 (DOI: 10.1002/anie.202013915) (Cover article).
- “Nature-inspired remodeling of (aza)indoles to meta-aminoaryl nicotinates for late-stage conjugation of vitamin B3 to (hetero)arylamines.” Varun, B.V.†; Vaithegi, K.†; Yi, S.; Park, S.B.* Nature Communications, 2020, 11: 6308.
- “Monochromophoric Design Strategy for Tetrazine-based Colorful Bioorthogonal Probes with a Single Fluorescent Core Skeleton.” Lee, Y.; Cho, W.; Sung, J.; Kim, E.*; Park, S. B.* J. Am. Chem. Soc., 2018, 140, 974–983 (Cover article).
- “Diversity-Oriented Synthetic Strategy for Developing Chemical Modulator of Protein–Protein Interaction.” Kim, J.; Koo, J.; Jung, J.; Cho, W.; Lee, W. S.; Kim, C.; Park, W.; Park, S.B.* Nature Communications, 2016, 7: 13196.
- “Discovery, Understanding, and Bioapplication of Organic Fluorophore: A Case Study with an Indolizine-Based Novel Fluorophore, Seoul-Fluor.” Kim, E.; Lee, Y.; Lee, S.; Park, S.B.* Acc. Chem. Res. 2015, 48(3), 538–547.
- “A Small Molecule Binding HMGB1 and HMGB2 Inhibits Microglia-Mediated Neuroinflammation.” Lee, S.; Nam, Y.; Koo, J.Y.; Lim, D.; Park, J.; Ock, J.; Suk, K.*; Park, S.B.* Nature Chemical Biology 2014 10(12), 1055–1060.
Search Papers
Heejun Kim, Ala Jo, Jaeyoung Ha, Youngjun Lee, Yoo Soo Hwang, Seung Bum Park
Ala Jo, JinJoo Jung, Eunha Kim, Seung Bum Park
Hankum Park, Ja Young Koo, Yellamelli V. V. Srikanth, Sangmi Oh, Jiyoon Lee, Jongmin Park, Seung Bum Park
Chanwoo Kim, Jinjoo Jung, Truong T Tung, Seung Bum Park
Sun-Sil Choi, Eun-Sun Kim, Ji-Eun Jung, David P. Marciano, Ala Jo, Ja Young Koo, Soo Youn Choi, Yong Ryoul Yang, Hyun-Jun Jang, Eung-Kyun Kim, Jiyoung Park, Hyug Moo Kwon, In Hee Lee, Seung Bum Park, Kyung-Jae Myung, Pann-Ghill Suh, Patrick R. Griffin, Jang Hyun Choi
Jongmin Park, Minseob Koh, Ja Young Koo, Sanghee Lee, Seung Bum Park, Jongmin Park
Youngjun Lee, Ala Jo, Seung Bum Park
Yaochen Zhang, Don-Kyu Kim, Ji-Min Lee, Seung Bum Park, Won-IL Jeong, Seong Heon Kim, In-Kyu Lee, Chul-Ho Lee, John Y.L. Chiang, Hueng-Sik Choi
107. Diverse Display of Non-covalent Interacting Elements Using Pyrimidine-embedded Polyheterocycles
Yoona Choi, Heejun Kim, Young-Hee Shin, Seung Bum Park
Eun Joung Choi, Seung Bum Park