Professor
Park, Seung Bum
Chemical Biology Laboratory
LAB Website
LAB Website
OFFICE
503-522
/
+82-2-880-9090
LAB
503-508,530
/
+82-2-880-4373
E-MAIL sbpark@snu.ac.kr
Research Topic
The main focus of my research is the identification and development of new bioactive chemical properties, which allow us to study the complex biological system as well as to utilize the new properties as potential therapeutic agents (drugs), through interdisciplinary approaches; Organic Chemistry, Bioassay, and Chemical Biology.
Design and synthesis of diverse and complex small molecules through Diversity Oriented Synthesis (DOS)
Development of new high-throughput screening for biological evaluation
Chemical Biology for the Application of identified bioactive small molecules
Design and synthesis of diverse and complex small molecules through Diversity Oriented Synthesis (DOS)
Development of new high-throughput screening for biological evaluation
Chemical Biology for the Application of identified bioactive small molecules
Education
- Ph.D. Chemistry, Texas A&M University, USA, 2001
- M.S. Chemistry, Yonsei University, Korea, 1997
- B.S. Chemistry, Yonsei University, Korea, 1993
Career
- Postdoctoral Research Fellow, Harvard University, 2001-2004
Papers
- “Phenotypic Discovery of Neuroprotective Agents by Regulation of Tau Proteostasis via Stress‐Responsive Activation of PERK Signaling.” Shin, Y.-H.; Cho, H.; Choi, B.Y.; Ha, J.; Kim, J.; Yim, J.; Suh, S.W.; Park, S.B.* Angew. Chem. Int. Ed., 2021 (DOI: 10.1002/anie.202013915) (Cover article).
- “Nature-inspired remodeling of (aza)indoles to meta-aminoaryl nicotinates for late-stage conjugation of vitamin B3 to (hetero)arylamines.” Varun, B.V.†; Vaithegi, K.†; Yi, S.; Park, S.B.* Nature Communications, 2020, 11: 6308.
- “Monochromophoric Design Strategy for Tetrazine-based Colorful Bioorthogonal Probes with a Single Fluorescent Core Skeleton.” Lee, Y.; Cho, W.; Sung, J.; Kim, E.*; Park, S. B.* J. Am. Chem. Soc., 2018, 140, 974–983 (Cover article).
- “Diversity-Oriented Synthetic Strategy for Developing Chemical Modulator of Protein–Protein Interaction.” Kim, J.; Koo, J.; Jung, J.; Cho, W.; Lee, W. S.; Kim, C.; Park, W.; Park, S.B.* Nature Communications, 2016, 7: 13196.
- “Discovery, Understanding, and Bioapplication of Organic Fluorophore: A Case Study with an Indolizine-Based Novel Fluorophore, Seoul-Fluor.” Kim, E.; Lee, Y.; Lee, S.; Park, S.B.* Acc. Chem. Res. 2015, 48(3), 538–547.
- “A Small Molecule Binding HMGB1 and HMGB2 Inhibits Microglia-Mediated Neuroinflammation.” Lee, S.; Nam, Y.; Koo, J.Y.; Lim, D.; Park, J.; Ock, J.; Suk, K.*; Park, S.B.* Nature Chemical Biology 2014 10(12), 1055–1060.
Search Papers
Jong In Kim, Jin Young Huh, Jee Hyung Sohn, Sung Sik Choe, Yun Sok Lee, Chun Yan Lim, Ala Jo, Seung Bum Park, Weiping Han, Jae Bum Kim
Eunha Kim, Youngjun Lee, Sanghee Lee, Seung Bum Park
Sanghee Lee, Youngpyo Nam, Ja Young Koo, Donghyun Lim, Jongmin Park, Jiyeon Ock, Jaehong Kim, Kyoungho Suk, Seung Bum Park
Jonghoon Kim, Heejun Kim, Seung Bum Park
Sun-Sil Choi, Eun Sun Kim, Minseob Koh, Soo-Jin Lee, Donghyun Lim, Yong Ryoul Yang, Hyun-Jun Jang, Kyung-ah Seo, Sang-Hyun Min, In Hee Lee, Seung Bum Park, Pann-Ghill Suh, Jang Hyun Choi
Sukjun Lee, Donghyun Lim, Eunyoung Lee, Nakyung Lee, Hong-gun Lee, Jonathan Cechetto, Michel Liuzzi, Lucio H. Freitas-Junior, Jin Sook Song, Myung Ae Bae, Sangmi Oh, Lawrence Ayong, Seung Bum Park
Jongmin Park, Jung In Um, Ala Jo, Jinho Lee, Da-Woon Jung, Darren R. Williams, Seung Bum Park
Minseob Koh, Jongmin Park, Ja Young Koo, Donghyun Lim, Mi Young Cha, Ala Jo, Jang Hyun Choi, Seung Bum Park
Don-Kyu Kim, Jae-Ho Jeong, Ji-Min Lee, Kwang Soo Kim, Seung-Hwan Park, Yong Deuk Kim, Minseob Koh, Minsang Shin, Yoon Seok Jung, Hyung-Seok Kim, Tae-Hoon Lee, Byung-Chul Oh, Jae Il Kim, Hwan Tae Park, Won-Il Jeong, Chul-Ho Lee, Seung Bum Park, Jung-Joon Min, Sook-In Jung, Seok-Yong Choi, Hyon E Choy, Hueng-Sik Choi
Yeon-Hui Jeong, Yongju Kim, Heebum Song, Young Sun Chung, Seung Bum Park, Hee-Sun Kim