Professor
LEE, Yan
Biomaterials Chemistry Lab.
LAB Website
LAB Website
OFFICE
503-122
/
+82-2-880-4344
LAB
503-101,130
/
+82-2-880-4359
E-MAIL gacn@snu.ac.kr
Research Topic
The objectives of our research group are to understand molecular-level interactions between biological systems and external signals, to control the interactions by synthetic molecules, and to develop new artificial materials on the basis of the interactions. Especially, our group wants to develop key molecular modules for efficient penetration into biosystems, for selective response to physical, chemical, or biological signals, and for escape from severe toxicity or foreign body reactions. We wants to combine the key molecular modules for overcoming the current limitations of biomaterials in clinical applications.
Education
- Ph. D. Chemistry, Seoul National University, Korea, 2005
- M. S. Chemistry, Seoul National University, Korea, 2001
- B. S. Chemistry, Seoul National University, Korea, 1999
Career
- Professor, Department of Chemistry, Seoul National University, Korea, 2022-Present
- Associate Professor, Department of Chemistry, Seoul National University, Korea, 2014-2022
- Assistant Professor, Department of Chemistry, Seoul National University, Korea, 2009-2014
- Project Assistant Professor, Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, the University of Tokyo, Japan, 2008-2009.
- Postdoctoral Fellow, Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, the University of Tokyo, Japan, 2005-2008.
Papers
- JACS Au 2021, 1, 11, 2070-2079 “Dynamics and entropy of cyclohexane rings control pH-responsive reactivity”
- ACS Applied Materials & Interfaces 2020, 12, 30198-30212 “Covalently grafted 2-methacryloyloxyethyl phosphorylcholine networks inhibit fibrous capsule formation around silicone breast implants in a porcine model”
- Chemical Communications 2019, 55, 10222-10225 “Guanidine cyclic diimides and their polymers”
- Advanced Science 2018, 5, 1800240 “Multimeric amphipathic α-helical sequences for rapid and efficient intracellular protein transport at nanomolar concentrations”
- Angewandte Chemie International Edition 2014, 53, 10086-10089 “Cell penetrating, dimeric α-helical peptides are nanomolar inhibitors of HIV-1 transcription”
Search Papers
Yujeong Jung, Soo Bin Ahn, Taeyang An, Hyeon-Min Cha, Minjae Kim, Hyunjin Cheon, Yejin Jang, Haemi Lee, Byungil Kim, Meehyein Kim, Yan Lee
Dong Sun Kim, Younghun Kim, Dongwhan Lee, Yan Lee
Jungah Kim, Sunah Kang, Min-Ha Choi, Sohyun Park, So Hee Nam, Ji-Ung Park, Yan Lee
So Yeon Yoon, Seung-No Hong, Yan Lee, Dae Woo Kim
Sungwhan Kim, Hyein Park, Fabian Fuẞ, Yan Lee
94. Effective cell penetration of negatively-charged proline-rich SAP(E) peptides with cysteine mutation
Sewon Lim, Jinhyuk Park, Seung-Eun Chong, Sungwhan Kim, Yoonhwa Choi, So Hee Nam, Yan Lee
Sejong Choi, Yeeun Lee, Jeongin Hwang, Dahyun Chun, Heebeom Koo, Yan Lee
So Hee Nam, Yan Lee, Chi-Heon Kim, Dong Eun Kim, Hee-Jin Yang, Sung Bae Park
Jinyoung Pac, Dong-Jun Koo, Hyeongjun Cho, Dongwook Jung, Min-ha Choi, Yunjung Choi, Bohyun Kim, Ji-Ung Park, Sung-Yon Kim, Yan Lee
Yuri Choi, Ji Su Park, Jinshil Kim, Kyungjin Min, Kiran Mahasenan, Choon Kim, Hye-Jin Yoon, Sewon Lim, Dae Hee Cheon, Yan Lee, Sangryeol Ryu, Shahriar Mobashery, B. Moon Kim, Hyung Ho Lee