Faculty

DEPARTMENT OF CHEMISTRY, SEOUL NATIONAL UNIVERSITY.

Professor

LEE, Yan

Biomaterials Chemistry Lab.
LAB Website
OFFICE 503-122 / +82-2-880-4344
LAB 503-101,130 / +82-2-880-4359

Research Topic

The objectives of our research group are to understand molecular-level interactions between biological systems and external signals, to control the interactions by synthetic molecules, and to develop new artificial materials on the basis of the interactions. Especially, our group wants to develop key molecular modules for efficient penetration into biosystems, for selective response to physical, chemical, or biological signals, and for escape from severe toxicity or foreign body reactions. We wants to combine the key molecular modules for overcoming the current limitations of biomaterials in clinical applications.

Education

  • Ph. D. Chemistry, Seoul National University, Korea, 2005
  • M. S. Chemistry, Seoul National University, Korea, 2001
  • B. S. Chemistry, Seoul National University, Korea, 1999

Career

  • Professor, Department of Chemistry, Seoul National University, Korea, 2022-Present
  • Associate Professor, Department of Chemistry, Seoul National University, Korea, 2014-2022
  • Assistant Professor, Department of Chemistry, Seoul National University, Korea, 2009-2014
  • Project Assistant Professor, Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, the University of Tokyo, Japan, 2008-2009.
  • Postdoctoral Fellow, Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, the University of Tokyo, Japan, 2005-2008.

Papers

  1. JACS Au 2021, 1, 11, 2070-2079 “Dynamics and entropy of cyclohexane rings control pH-responsive reactivity”
  2. ACS Applied Materials & Interfaces 2020, 12, 30198-30212 “Covalently grafted 2-methacryloyloxyethyl phosphorylcholine networks inhibit fibrous capsule formation around silicone breast implants in a porcine model”
  3. Chemical Communications 2019, 55, 10222-10225 “Guanidine cyclic diimides and their polymers”
  4. Advanced Science 2018, 5, 1800240 “Multimeric amphipathic α-helical sequences for rapid and efficient intracellular protein transport at nanomolar concentrations”
  5. Angewandte Chemie International Edition 2014, 53, 10086-10089 “Cell penetrating, dimeric α-helical peptides are nanomolar inhibitors of HIV-1 transcription”

Search Papers

Jin Hee Na, Jae-Gon Lee, Seul-Chan Hong, JaeMin Seo, Jung Pyo Lee, Yan Lee, Jong-Ho Kim, Yong-Su Na, Sangmin Lee, Ji-Ung Park
Current Applied Physics, 2020, 20, 12, (2020-12) Link
Joon Hyung Ahn, Sunah Kang, Sohyun Park, Hojoon Song, Yaejin Yun, Sejong Choi, Seung-Eun Chong, Dae Hee Cheon, Dahyun Chun, Jae Hoon Oh, Sohee Nam, Yan Lee
Biomacromolecules, 2020, 21, 9, (2020-09-14) Link
Youngjun Song, Sunyoung Kang, Sangyoon Kang, Yan Lee
Angewandte Chemie-International Edition, 2020, 2020, 59, (2020-09) Link
Jiyeon Ham, Youngmin Kim, Taeyang An, Sunah Kang, Cheolmin Ha, Maierdanjiang Wufue, Yumin Kim, Byoungjun Jeon, Seulah Kim, Jungah Kim, Tae Hyun Choi, Ji-Hun Seo, Dae Woo Kim, Ji-Ung Park, Yan Lee
ACS Applied Materials & Interfaces, 2020, 12, 27, (2020-07-08) Link
Sunah Kang, Jungah Kim, Seulah Kim, Maierdanjiang Wufuer, Sohyun Park, Youngmin Kim, Dongkil Choi, Xian Jin, Yumin Kim, Yan Huang, Byoungjun Jeon, Tae Hyun Choi, Ji-Ung Park, Yan Lee
Biomaterials Science, 2020, 8, 6, (2020-03-17) Link
So Hee Nam, Yan Lee, Joon Hyung Ahn, Chun Kee Chung, Hee-Jin Yang, Sangmok Jang, Sung Bae Park
European Journal of Pharmaceutical Sciences, 2020, 144, (2020-03-01) Link
Yumin Kim, Soyoung Hwang, Roza Khalmuratova, Sunah Kang, Mingyu Lee, Youngjun Song, Jong-Wan Park, Jaehoon Yu, Hyun-Woo Shin, Yan Lee
Journal of Controlled Release, 2020, 317, (2020-01-10) Link
Dongwook Jung, Dongkil Choi, Changgon Sim, Yumin Kim, Sunyoung Kang, So Hee Nam, Joomyung Jang, Dokyoung Kim, Mee Soo Chang, Ji-Ung Park, Yan Lee
Chemical Communications, 2020, 56, 1, (2020-01-04) Link
Han‐Eol Park, Dongkil Choi, Ji Su Park, Changgon Sim, Sohyun Park, Sunah Kang, Hyunsoo Yim, Myungsun Lee, Jaeyoun Kim, Jinyoung Pac, Kunsoo Rhee, Junho Lee, Yunjong Lee, Yan Lee, Sung-Yon Kim
Advanced Science, 2019, 6, 22, (2019-11-20) Link