Faculty

DEPARTMENT OF CHEMISTRY, SEOUL NATIONAL UNIVERSITY.

Professor

LEE, Yan

Biomaterials Chemistry Lab.
LAB Website
OFFICE 503-122 / +82-2-880-4344
LAB 503-101,130 / +82-2-880-4359

Research Topic

The objectives of our research group are to understand molecular-level interactions between biological systems and external signals, to control the interactions by synthetic molecules, and to develop new artificial materials on the basis of the interactions. Especially, our group wants to develop key molecular modules for efficient penetration into biosystems, for selective response to physical, chemical, or biological signals, and for escape from severe toxicity or foreign body reactions. We wants to combine the key molecular modules for overcoming the current limitations of biomaterials in clinical applications.

Education

  • Ph. D. Chemistry, Seoul National University, Korea, 2005
  • M. S. Chemistry, Seoul National University, Korea, 2001
  • B. S. Chemistry, Seoul National University, Korea, 1999

Career

  • Professor, Department of Chemistry, Seoul National University, Korea, 2022-Present
  • Associate Professor, Department of Chemistry, Seoul National University, Korea, 2014-2022
  • Assistant Professor, Department of Chemistry, Seoul National University, Korea, 2009-2014
  • Project Assistant Professor, Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, the University of Tokyo, Japan, 2008-2009.
  • Postdoctoral Fellow, Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, the University of Tokyo, Japan, 2005-2008.

Papers

  1. JACS Au 2021, 1, 11, 2070-2079 “Dynamics and entropy of cyclohexane rings control pH-responsive reactivity”
  2. ACS Applied Materials & Interfaces 2020, 12, 30198-30212 “Covalently grafted 2-methacryloyloxyethyl phosphorylcholine networks inhibit fibrous capsule formation around silicone breast implants in a porcine model”
  3. Chemical Communications 2019, 55, 10222-10225 “Guanidine cyclic diimides and their polymers”
  4. Advanced Science 2018, 5, 1800240 “Multimeric amphipathic α-helical sequences for rapid and efficient intracellular protein transport at nanomolar concentrations”
  5. Angewandte Chemie International Edition 2014, 53, 10086-10089 “Cell penetrating, dimeric α-helical peptides are nanomolar inhibitors of HIV-1 transcription”

Search Papers

Heebeom Koo, Geun-woo Jin, Yan Lee, Heejung Mo, Min Yi Cho, Jong-Sang Park
Bulletin of The Korean Chemical Society, 2005, 26, 12, (2005-12-20) Link
Yan Lee, Heebeom Koo, Geun-woo Jin, Heejung Mo, Min Yi Cho, Jong-Yeun Park, Joon Sig Choi, Jong-Sang Park
Biomacromolecules, 2005, 6, 1, (2005-01-01) Link
Yan Lee, Heebeom Koo, Yong-beom Lim, Youngeun Lee, Heejung Mo, Jong-Sang Park
Bioorganic & Medicinal Chemistry Letters, 2004, 14, 10, (2004-05-17) Link
Jung Hoon Lee, Yong-beom Lim, Joon Sig Choi, Yan Lee, Tae-il Kim, Hyun Jin Kim, Jae Keun Yoon, Kwan Kim, Jong-Sang Park
Bioconjugate Chemistry, 2003, 14, 6, (2003-11-01) Link
M-J Lee, S-S Cho, J-R You, Yan Lee, B-D Kang, J S Choi, J-W Park, Y-L Suh, J-A Kim, D-K Kim, Jong-Sang Park
Gene Therapy, 2002, 9, 13, (2002-07-01) Link
Yong-beom Lim, Seon-Mi Kim, Yan Lee, Woo-kyoung Lee, Tae-gyun Yang, Min-jae Lee, Hearan Suh, Jong-Sang Park
Journal of The American Chemical Society, 2001, 123, 10, (2001-03-14) Link
Yong-Beom Lim, Sang-Oh Han, Han-Uk Kong, Yan Lee, Jong-Sang Park, Byeongmoon Jeong, Sung Wan Kim
Pharmaceutical Research, 2000, 17, 7, (2000-07-01) Link