Faculty

DEPARTMENT OF CHEMISTRY, SEOUL NATIONAL UNIVERSITY.

Professor

LEE, Yan

Biomaterials Chemistry Lab.
LAB Website
OFFICE 503-122 / +82-2-880-4344
LAB 503-101,130 / +82-2-880-4359

Research Topic

The objectives of our research group are to understand molecular-level interactions between biological systems and external signals, to control the interactions by synthetic molecules, and to develop new artificial materials on the basis of the interactions. Especially, our group wants to develop key molecular modules for efficient penetration into biosystems, for selective response to physical, chemical, or biological signals, and for escape from severe toxicity or foreign body reactions. We wants to combine the key molecular modules for overcoming the current limitations of biomaterials in clinical applications.

Education

  • Ph. D. Chemistry, Seoul National University, Korea, 2005
  • M. S. Chemistry, Seoul National University, Korea, 2001
  • B. S. Chemistry, Seoul National University, Korea, 1999

Career

  • Professor, Department of Chemistry, Seoul National University, Korea, 2022-Present
  • Associate Professor, Department of Chemistry, Seoul National University, Korea, 2014-2022
  • Assistant Professor, Department of Chemistry, Seoul National University, Korea, 2009-2014
  • Project Assistant Professor, Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, the University of Tokyo, Japan, 2008-2009.
  • Postdoctoral Fellow, Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, the University of Tokyo, Japan, 2005-2008.

Papers

  1. JACS Au 2021, 1, 11, 2070-2079 “Dynamics and entropy of cyclohexane rings control pH-responsive reactivity”
  2. ACS Applied Materials & Interfaces 2020, 12, 30198-30212 “Covalently grafted 2-methacryloyloxyethyl phosphorylcholine networks inhibit fibrous capsule formation around silicone breast implants in a porcine model”
  3. Chemical Communications 2019, 55, 10222-10225 “Guanidine cyclic diimides and their polymers”
  4. Advanced Science 2018, 5, 1800240 “Multimeric amphipathic α-helical sequences for rapid and efficient intracellular protein transport at nanomolar concentrations”
  5. Angewandte Chemie International Edition 2014, 53, 10086-10089 “Cell penetrating, dimeric α-helical peptides are nanomolar inhibitors of HIV-1 transcription”

Search Papers

Sunyoung Kang, Chanwoo Noh, Hyosik Kang, Ji-Yeon Shin, So-Young Kim, Seulah Kim, Moon-Gi Son, Eunseok Park, Hyun Kyu Song, Seokmin Shin, Sanghun Lee, Nak-Kyoon Kim, YounJoon Jung, Yan Lee
JACS Au, 2021, 1, 11, (2021-09-24) Link
Seung-Eun Chong, Donghyun Lee, Jae Hoon Oh, Sunyoung Kang, Sejong Choi, So Hee Nam, Jaehoon Yu, Heebeom Koo, Yan Lee
Biomaterials Science, 2021, 9, (2021-08-12) Link
Sunah Kang, Sohyun Park, Hojoon Song, Dongkil Choi, Han-Eol Park, Benjamin H. Ahn, Sung-Yon Kim, Yan Lee
ACS Applied Materials & Interfaces, 2021, 13, 24, (2021-06-10) Link
Gyu Chan Kim, Dae Hee Cheon, Yan Lee
Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2021, 1869, 4, (2021-03-25) Link
Seung-Eun Chong, Jae Hoon Oh, Kyungjin Min, Sohyun Park, Sejong Choi, Joon Hyung Ahn, Dahyun Chun, Hyung Ho Lee, Jaehoon Yu, Yan Lee
Journal of Controlled Release, 2021, 330, (2021-02-10) Link
So Hee Nam, Joomyung Jang, Dae Hee Cheon, Seung-Eun Chong, Joon Hyung Ahn, Soonsil Hyun, Jaehoon Yu, Yan Lee
Journal of Controlled Release, 2021, 330, (2021-02-10) Link
Soonsil Hyun, Namjoon Park, So Hee Nam, Dae Hee Cheon, Yan Lee, Hyun-Suk Lim, Jaehoon Yu
Chemical Communications, 2021, 58, (2021-01-28) Link
Minji Ha, So Hee Nam, Kyunjong Sim, Seung-Eun Chong, Jiyeon Kim, Yuna Kim, Yan Lee, Jwa-Min Nam
Nano letters, 2021, 21, 1, (2021-01-13) Link
Sunah Kang, Sohyun Park, Insu Baek, Youngjun Song, Sungwhan Kim, Dongkil Choi, Jungah Kim, Yan Lee
Materials Science and Engineering, 2021, 120, (2021-01-01) Link