교수
석차옥 Seok, Chaok
연구내용
Our ultimate goal is to understand detailed mechanisms underlying biological phenomena using computational and theoretical tools, and to contribute to curing diseases using the knowledge obtained from such studies. We are currently developing mathematical and computational techniques to model and to simulate biomolecules more efficiently and accurately. An example is an analytical loop closure method that can be used to model flexibilities in proteins loops and cyclic peptides. We will apply these methods to prediction of protein structures and biomolecular interactions, and also extend such experiences to design of new drugs and proteins.
학력
- Ph.D. Chemistry, University of Chicago, USA, 1998
- M.S. Chemistry, University of Chicago, USA, 1995
- B.S. Chemistry, Seoul National University, Korea, 1993
주요 경력
- Research Associate, University of Chicago, 1999
- Research Associate, Massachusetts Institute of Technology, 2000
- Research Associate, University of California, San Francisco, 2000-2004
주요 논문
- J. Yang, S. Kwon, S.-H. Bae, K. M. Park, C. Yoon, J.-H. Lee, and C. Seok, GalaxySagittarius: Structure- and Similarity-Based Prediction of Protein Targets for Druglike Compounds, J. Chem. Inf. Model, 60 (6), 3246-3254 (2020).
- J. Yang, M. Baek, and C. Seok, GalaxyDock3: Protein-ligand docking that considers the full ligand conformational flexibility, J. Comput. Chem. 40 (31), 2739-2748 (2019).
- J. Won, G. R. Lee, H. Park, and C. Seok, GalaxyGPCRloop: Template-Based and Ab Initio Structure Sampling of the Extracellular Loops of G-Protein-Coupled Receptors, J. Chem. Inf. Model, 58 (6), 1234-1243 (2018).
- G. R. Lee and C. Seok, Galaxy7TM: Flexible GPCR-ligand docking by structure refinement, Nucleic Acids Res. 44 (W1), W502-506 (2016).
- H. Park, H. Lee, and C. Seok, High-resolution Protein-protein Docking by Global Optimization: Recent Advances and Future Challenges, Current Opinion in Structural Biology, 35, 24-31 (2015).
- H. Lee, L. Heo, M. S. Lee, and C. Seok, GalaxyPepDock: a protein-peptide docking tool based on interaction similarity and energy optimization, Nucleic Acids Res. 43 (W1), W431-W435 (2015).
논문 검색
Chaok Seok, Minkyung Baek, Martin Steinegger, Hahnbeom Park, Gyu Rie Lee, Jonghun Won
Sohee Kwon, Jonghun Won, Andriy Kryshtafovych, Chaok Seok
85. GalaxyHeteromer: protein heterodimer structure prediction by template-based and ab initio docking
Taeyong Park, Jonghun Won, Minkyung Baek, Chaok Seok
Lim Heo, Sangwoo Park, Chaok Seok
Yeol Kyo Choi, Yiwei Cao, Martin Frank, Hyeonuk Woo, Sang-Jun Park, Min Sun Yeom, Tristan I. Croll, Chaok Seok, Wonpil Im
Jaeseung Yu, Jinsol Yang, Chaok Seok, Woon Ju Song
Beomchang Kang, Chaok Seok, Juyong Lee
Jinuk Kim, Wonhee Han, Taeyong Park, Eun Jin Kim, Injin Bang, Hyun Sik Lee, Yejing Jeong, Kyeonghwan Roh, Jeesoo Kim, Jong-Seo Kim, Chanhee Kang, Chaok Seok, Jin-Kwan Han, Hee-Jung Choi
Hyeonuk Woo, Sang-Jun Park, Yeol Kyo Choi, Taeyong Park, Maham Tanveer, Yiwei Cao, Nathan R. Kern, Jumin Lee, Min Sun Yeom, Tristan I. Croll, Chaok Seok, Wonpil Im
Taeyong Park, Hyeonuk Woo, Minkyung Baek, Jinsol Yang, Chaok Seok
