화학부교수

DEPARTMENT OF CHEMISTRY, SEOUL NATIONAL UNIVERSITY.

조교수

이홍근 Lee, Hong Geun

합성유기화학 연구실
LAB Website
OFFICE 503-620 / 02-880-6651
LAB 503-606, 629 / 02-880-6815

연구내용

Our mission is to address unmet synthetic needs to solve various problems of biomedical research. To this end, novel strategies to access natural and unnatural small molecules as well as biopolymers are being investigated. More specifically, we are developing target-oriented syntheses that can rapidly increase the molecular complexity of the desired therapeutics. At the same time, transition metal-based synthetic methods that should allow for the preparation of analogues of biologically important biopolymers are being explored. Eventually, the accumulated knowledge should serve to solve problems associated with important therapeutic issues, such as opioid addiction and antibiotic resistance.

학력

  • Ph.D. Chemistry, Harvard University, USA, 2012
  • M.S. Chemistry, Seoul National University, Republic of Korea, 2006
  • B.S. Chemistry, Seoul National University, Republic of Korea, 2002

주요 경력

  • Assistant Professor, Seoul National University, Republic of Korea, 2017-Present
  • Research Investigator, Bristol-Myers Squibb, USA, 2016-2017
  • Postdoctoral Associate, MIT, USA, 2012-2016

주요 논문

  1. “Palladium-mediated Arylation of Lysine in Unprotected Peptides.” Lee, H. G.; Lautrette, G.; Pentelute. B. L.; Buchwald, S. L. Angew. Chem. Int. Ed. 2017, 56, 3177.
  2. “Virtually Instantaneous, Room-temperature [11C]-Cyanation Using Biaryl Phosphine Pd(0) Complexes.” Lee, H. G.; Milner, P. J.; Placzek, M. S.; Buchwald, S. L.; Hooker, J. M. J. Am. Chem. Soc. 2015, 137, 648.
  3. “Pd-Catalyzed Nucleophilic Fluorination of Aryl Bromides.” Lee, H. G.; Milner, P. J.; Buchwald, S. L. J. Am. Chem. Soc. 2014, 136, 3792.
  4. “nantioselective Synthesis of the Full Carbon Skeleton of the Lomaiviticin Aglycone Reveals Remarkable Remote Substituent Effects in the Dimerization Event.” Lee, H. G.; Ahn, J.; Lee, A. S.; Shair, M. D. Chem. Eur. J. 2010, 16, 13058.

논문 검색

Samuel J. Shin, Ji Yong Kim, Sohee An, Moonjoo Kim, Minjee Seo, Su Yong Go, Hyunho Chung, MinKeun Lee, Min-Gyeong Kim, Hong Geun Lee, Taek Dong Chung
Analytical Chemistry, 2022, 94, 2, 1248–1255, (2022-01-18) Link
Inseok Song, Younghyeon Kim, Jaeseung Yu, Su Yong Go, Hong Geun Lee, Woon Ju Song, Seokhee Kim
Nature Chemical Biology, 2021, 17, 1123–1131 , (2021-09-02) Link
Hyunho Chung, Jeongyun Kim, Gisela A. González-Montiel, Paul Ha-Yeon Cheong, Hong Geun Lee
Organic Letters, 2021, 23, 3, 1096–1102, (2021-02-05) Link
Wenjun Zhao, Hong Geun Lee, Stephen L. Buchwald, Jacob M. Hooker
Journal of The American Chemical Society, 2017, 139, 21, 7152-7155, (2017-05-31) Link
Hong Geun Lee, Guillaume Lautrette, Bradley L. Pentelute, Stephen L. Buchwald
Angewandte Chemie-International Edition, 2017, 56, 12, 3177-3181, (2017-03-13) Link
Hong Geun Lee, Phillip J. Milner, Michael S. Placzek, Stephen L. Buchwald, Jacob M. Hooker
Journal of The American Chemical Society, 2015, 137, 2, 648-651, (2015-01-21) Link