부교수
이홍근 Lee, Hong Geun
합성유기화학 연구실
LAB Website
LAB Website
OFFICE
503-620
/
02-880-6651
LAB
503-606, 629
/
02-880-6815
E-MAIL hgleee@snu.ac.kr
연구내용
Our mission is to address unmet synthetic needs to solve various problems of biomedical research. To this end, novel strategies to access natural and unnatural small molecules as well as biopolymers are being investigated. More specifically, we are developing target-oriented syntheses that can rapidly increase the molecular complexity of the desired therapeutics. At the same time, transition metal-based synthetic methods that should allow for the preparation of analogues of biologically important biopolymers are being explored. Eventually, the accumulated knowledge should serve to solve problems associated with important therapeutic issues, such as opioid addiction and antibiotic resistance.
학력
- Ph.D. Chemistry, Harvard University, USA, 2012
- M.S. Chemistry, Seoul National University, Republic of Korea, 2006
- B.S. Chemistry, Seoul National University, Republic of Korea, 2002
주요 경력
- Assistant Professor, Seoul National University, Republic of Korea, 2017-Present
- Research Investigator, Bristol-Myers Squibb, USA, 2016-2017
- Postdoctoral Associate, MIT, USA, 2012-2016
주요 논문
- “Palladium-mediated Arylation of Lysine in Unprotected Peptides.” Lee, H. G.; Lautrette, G.; Pentelute. B. L.; Buchwald, S. L. Angew. Chem. Int. Ed. 2017, 56, 3177.
- “Virtually Instantaneous, Room-temperature [11C]-Cyanation Using Biaryl Phosphine Pd(0) Complexes.” Lee, H. G.; Milner, P. J.; Placzek, M. S.; Buchwald, S. L.; Hooker, J. M. J. Am. Chem. Soc. 2015, 137, 648.
- “Pd-Catalyzed Nucleophilic Fluorination of Aryl Bromides.” Lee, H. G.; Milner, P. J.; Buchwald, S. L. J. Am. Chem. Soc. 2014, 136, 3792.
- “nantioselective Synthesis of the Full Carbon Skeleton of the Lomaiviticin Aglycone Reveals Remarkable Remote Substituent Effects in the Dimerization Event.” Lee, H. G.; Ahn, J.; Lee, A. S.; Shair, M. D. Chem. Eur. J. 2010, 16, 13058.
논문 검색
Jangwoo Koo, Weonjeong Kim, Byung Hak Jhun, Subin Park, Dayoon Song, Youngmin You, Hong Geun Lee
Byeongdo Roh, Hong Geun Lee
Ju Hyun Youn, Su Yong Go, Hyunho Chung, Haeyeon Lee, Taek Dong Chung, Paul Ha-Yeon Cheong, Hong Geun Lee
Yujin Lee, Yun Seung Nam, Soo Young Kim, Jeong Eun Kia, Hong Geun Lee
Byeongdo Roh, Abdikani Omar Farah, Beomsu Kim, Taisiia Feoktistova, Finn Moeller, Kyeong Do Kim, Paul Ha-Yeon Cheong, Hong Geun Lee
Dogyun Kim, Jeong Min Lee, Jeongeun Song, Seul Woo Lee, Hong Geun Lee, Kyoung Taek Kim
Samuel J. Shin, Ji Yong Kim, Sohee An, Moonjoo Kim, Minjee Seo, Su Yong Go, Hyunho Chung, MinKeun Lee, Min-Gyeong Kim, Hong Geun Lee, Taek Dong Chung
Dong Sun Kim, Hong Geun Lee
Hyunho Chung, Jeongyun Kim, Gisela A. González-Montiel, Paul Ha-Yeon Cheong, Hong Geun Lee