Our mission is to address unmet synthetic needs to solve various problems of biomedical research. To this end, novel strategies to access natural and unnatural small molecules as well as biopolymers are being investigated. More specifically, we are developing target-oriented syntheses that can rapidly increase the molecular complexity of the desired therapeutics. At the same time, transition metal-based synthetic methods that should allow for the preparation of analogues of biologically important biopolymers are being explored. Eventually, the accumulated knowledge should serve to solve problems associated with important therapeutic issues, such as opioid addiction and antibiotic resistance.
- Ph.D. Chemistry, Harvard University, USA, 2012
- M.S. Chemistry, Seoul National University, Republic of Korea, 2006
- B.S. Chemistry, Seoul National University, Republic of Korea, 2002
- Assistant Professor, Seoul National University, Republic of Korea, 2017-Present
- Research Investigator, Bristol-Myers Squibb, USA, 2016-2017
- Postdoctoral Associate, MIT, USA, 2012-2016
- “Palladium-mediated Arylation of Lysine in Unprotected Peptides.” Lee, H. G.; Lautrette, G.; Pentelute. B. L.; Buchwald, S. L. Angew. Chem. Int. Ed. 2017, 56, 3177.
- “Virtually Instantaneous, Room-temperature [11C]-Cyanation Using Biaryl Phosphine Pd(0) Complexes.” Lee, H. G.; Milner, P. J.; Placzek, M. S.; Buchwald, S. L.; Hooker, J. M. J. Am. Chem. Soc. 2015, 137, 648.
- “Pd-Catalyzed Nucleophilic Fluorination of Aryl Bromides.” Lee, H. G.; Milner, P. J.; Buchwald, S. L. J. Am. Chem. Soc. 2014, 136, 3792.
- “nantioselective Synthesis of the Full Carbon Skeleton of the Lomaiviticin Aglycone Reveals Remarkable Remote Substituent Effects in the Dimerization Event.” Lee, H. G.; Ahn, J.; Lee, A. S.; Shair, M. D. Chem. Eur. J. 2010, 16, 13058.
11. Synthesis of Enantiomeric ω-Substituted Hydroxy Acids from Terminal Epoxides and Alkenes: Functional Building Blocks for Discrete and Sequence-Defined Polyesters
Macromolecules, 2022, 55, 16, 7193–7203, (2022-08-23)
10. Revisiting Thin-Layer Electrochemistry in a Chip-Type Cell for the Study of Electro-organic Reactions
Samuel J. Shin, Ji Yong Kim, Sohee An, Moonjoo Kim, Minjee Seo, Su Yong Go, Hyunho Chung, MinKeun Lee, Min-Gyeong Kim, Hong Geun Lee, Taek Dong Chung
Analytical Chemistry, 2022, 94, 2, 1248–1255, (2022-01-18)
9. Formation of the Tertiary Sulfonamide C(sp3)–N Bond Using Alkyl Boronic Ester via Intramolecular and Intermolecular Copper-Catalyzed Oxidative Cross-Coupling
Dong Sun Kim, Hong Geun Lee
The Journal of Organic Chemistry, 2021, 86, 23, 17380–17394, (2021-12-03)
Nature Chemical Biology, 2021, 17, 1123–1131 , (2021-09-02)
Hyunho Chung, Jeongyun Kim, Gisela A. González-Montiel, Paul Ha-Yeon Cheong, Hong Geun Lee
Organic Letters, 2021, 23, 3, 1096–1102, (2021-02-05)
6. Benzylic C(sp3)–C(sp2) cross-coupling of indoles enabled by oxidative radical generation and nickel catalysis
Weonjeong Kim, Jangwoo Koo, Hong Geun Lee
Chemical Science, 2021, 11, 1-7, (2021-02-02)
5. Restoration of catalytic activity by the preservation of ligand structure: Cu-catalysed asymmetric conjugate addition with 1,1-diborylmethane
Changhee Kim, Byeongdo Roh, Hong Geun Lee
Chemical Science, 2021, 23, 3668, (2021-01-21)
4. Direct 11CN-Labeling of Unprotected Peptides via Palladium-Mediated Sequential Cross-Coupling Reactions
Wenjun Zhao, Hong Geun Lee, Stephen L. Buchwald, Jacob M. Hooker
Journal of The American Chemical Society, 2017, 139, 21, 7152-7155, (2017-05-31)
Hong Geun Lee, Guillaume Lautrette, Bradley L. Pentelute, Stephen L. Buchwald
Angewandte Chemie-International Edition, 2017, 56, 12, 3177-3181, (2017-03-13)
Hong Geun Lee, Phillip J. Milner, Michael S. Placzek, Stephen L. Buchwald, Jacob M. Hooker
Journal of The American Chemical Society, 2015, 137, 2, 648-651, (2015-01-21)