Professor
Park, Seung Bum
Chemical Biology Laboratory
LAB Website
LAB Website
OFFICE
503-522
/
+82-2-880-9090
LAB
503-508,530
/
+82-2-880-4373
E-MAIL sbpark@snu.ac.kr
Research Topic
The main focus of my research is the identification and development of new bioactive chemical properties, which allow us to study the complex biological system as well as to utilize the new properties as potential therapeutic agents (drugs), through interdisciplinary approaches; Organic Chemistry, Bioassay, and Chemical Biology.
Design and synthesis of diverse and complex small molecules through Diversity Oriented Synthesis (DOS)
Development of new high-throughput screening for biological evaluation
Chemical Biology for the Application of identified bioactive small molecules
Design and synthesis of diverse and complex small molecules through Diversity Oriented Synthesis (DOS)
Development of new high-throughput screening for biological evaluation
Chemical Biology for the Application of identified bioactive small molecules
Education
- Ph.D. Chemistry, Texas A&M University, USA, 2001
- M.S. Chemistry, Yonsei University, Korea, 1997
- B.S. Chemistry, Yonsei University, Korea, 1993
Career
- Postdoctoral Research Fellow, Harvard University, 2001-2004
Papers
- “Phenotypic Discovery of Neuroprotective Agents by Regulation of Tau Proteostasis via Stress‐Responsive Activation of PERK Signaling.” Shin, Y.-H.; Cho, H.; Choi, B.Y.; Ha, J.; Kim, J.; Yim, J.; Suh, S.W.; Park, S.B.* Angew. Chem. Int. Ed., 2021 (DOI: 10.1002/anie.202013915) (Cover article).
- “Nature-inspired remodeling of (aza)indoles to meta-aminoaryl nicotinates for late-stage conjugation of vitamin B3 to (hetero)arylamines.” Varun, B.V.†; Vaithegi, K.†; Yi, S.; Park, S.B.* Nature Communications, 2020, 11: 6308.
- “Monochromophoric Design Strategy for Tetrazine-based Colorful Bioorthogonal Probes with a Single Fluorescent Core Skeleton.” Lee, Y.; Cho, W.; Sung, J.; Kim, E.*; Park, S. B.* J. Am. Chem. Soc., 2018, 140, 974–983 (Cover article).
- “Diversity-Oriented Synthetic Strategy for Developing Chemical Modulator of Protein–Protein Interaction.” Kim, J.; Koo, J.; Jung, J.; Cho, W.; Lee, W. S.; Kim, C.; Park, W.; Park, S.B.* Nature Communications, 2016, 7: 13196.
- “Discovery, Understanding, and Bioapplication of Organic Fluorophore: A Case Study with an Indolizine-Based Novel Fluorophore, Seoul-Fluor.” Kim, E.; Lee, Y.; Lee, S.; Park, S.B.* Acc. Chem. Res. 2015, 48(3), 538–547.
- “A Small Molecule Binding HMGB1 and HMGB2 Inhibits Microglia-Mediated Neuroinflammation.” Lee, S.; Nam, Y.; Koo, J.Y.; Lim, D.; Park, J.; Ock, J.; Suk, K.*; Park, S.B.* Nature Chemical Biology 2014 10(12), 1055–1060.
Search Papers
Eun Joung Choi, Eunha Kim, Youngjun Lee, Ala Jo, Seung Bum Park
Jonghoon Kim, Won Seok Lee, Jaeyoung Koo, Jeongae Lee, Seung Bum Park
Duk-Hwa Kwon, Gwang Hyeon Eom, Hae Jin Kee, Yoon Seok Nam, Young Kuk Cho, Don-Kyu Kim, Ja Young Kooi, Hyung-Seok Kim, Kwang-Il Nam, Kyung Keun Kim, In-Kyu Lee, Seung Bum Park, Hueng-Sik Choi, Hyun Kook
Heejun Kim, Truong Thanh Tung, Seung Bum Park
91. Measurement of Lipid Droplet Accumulation Kinetics in Chlamydomonas reinhardtii Using Seoul-Fluor
Jae Woo Park, Sang Cheol Na, Youngjun Lee, Sanghee Lee, Seung Bum Park, Noo Li Jeon
Arash Minai-Tehrani, Seung‑Hee Chang, Seung Bum Park, Myung‑Haing Cho
Kuk-Youn Ju, Jae Won Lee, Geun Ho Im, Sanghee Lee, Jung Pyo, Seung Bum Park, Jung Hee Lee, Jin-Kyu Lee
Ja Young Koo, Sangmi Oh, Seung-Rye Cho, Minseob Koh, Won-Keun Oh, Hueng-Sik Choi, Seung Bum Park
Yongju Kim, Keunhee Oh, Heebum Song, Dong-Sup Lee, Seung Bum Park
Don-Kyu Kim, Gil-Tae Gang, Dongryeol Ryu, Minseob Koh, Yo-Na Kim, Su Sung Kim, Jinyoung Park, Yong-Hoon Kim, Taebo Sim, In-Kyu Lee, Cheol Soo Choi, Seung Bum Park, Chul-Ho Lee, Seung-Hoi Koo, Hueng-Sik Choi