Professor
Park, Seung Bum
Chemical Biology Laboratory
LAB Website
LAB Website
OFFICE
503-522
/
+82-2-880-9090
LAB
503-508,530
/
+82-2-880-4373
E-MAIL sbpark@snu.ac.kr
Research Topic
The main focus of my research is the identification and development of new bioactive chemical properties, which allow us to study the complex biological system as well as to utilize the new properties as potential therapeutic agents (drugs), through interdisciplinary approaches; Organic Chemistry, Bioassay, and Chemical Biology.
Design and synthesis of diverse and complex small molecules through Diversity Oriented Synthesis (DOS)
Development of new high-throughput screening for biological evaluation
Chemical Biology for the Application of identified bioactive small molecules
Design and synthesis of diverse and complex small molecules through Diversity Oriented Synthesis (DOS)
Development of new high-throughput screening for biological evaluation
Chemical Biology for the Application of identified bioactive small molecules
Education
- Ph.D. Chemistry, Texas A&M University, USA, 2001
- M.S. Chemistry, Yonsei University, Korea, 1997
- B.S. Chemistry, Yonsei University, Korea, 1993
Career
- Postdoctoral Research Fellow, Harvard University, 2001-2004
Papers
- “Phenotypic Discovery of Neuroprotective Agents by Regulation of Tau Proteostasis via Stress‐Responsive Activation of PERK Signaling.” Shin, Y.-H.; Cho, H.; Choi, B.Y.; Ha, J.; Kim, J.; Yim, J.; Suh, S.W.; Park, S.B.* Angew. Chem. Int. Ed., 2021 (DOI: 10.1002/anie.202013915) (Cover article).
- “Nature-inspired remodeling of (aza)indoles to meta-aminoaryl nicotinates for late-stage conjugation of vitamin B3 to (hetero)arylamines.” Varun, B.V.†; Vaithegi, K.†; Yi, S.; Park, S.B.* Nature Communications, 2020, 11: 6308.
- “Monochromophoric Design Strategy for Tetrazine-based Colorful Bioorthogonal Probes with a Single Fluorescent Core Skeleton.” Lee, Y.; Cho, W.; Sung, J.; Kim, E.*; Park, S. B.* J. Am. Chem. Soc., 2018, 140, 974–983 (Cover article).
- “Diversity-Oriented Synthetic Strategy for Developing Chemical Modulator of Protein–Protein Interaction.” Kim, J.; Koo, J.; Jung, J.; Cho, W.; Lee, W. S.; Kim, C.; Park, W.; Park, S.B.* Nature Communications, 2016, 7: 13196.
- “Discovery, Understanding, and Bioapplication of Organic Fluorophore: A Case Study with an Indolizine-Based Novel Fluorophore, Seoul-Fluor.” Kim, E.; Lee, Y.; Lee, S.; Park, S.B.* Acc. Chem. Res. 2015, 48(3), 538–547.
- “A Small Molecule Binding HMGB1 and HMGB2 Inhibits Microglia-Mediated Neuroinflammation.” Lee, S.; Nam, Y.; Koo, J.Y.; Lim, D.; Park, J.; Ock, J.; Suk, K.*; Park, S.B.* Nature Chemical Biology 2014 10(12), 1055–1060.
Search Papers
Tae-Jun Cho, Jonghoon Kim, Soon-Keun Kwon, Keunhee Oh, Jeong-ae Lee, Dong-Sup Lee, Jaejin Cho, Seung Bum Park
Ja Hee Lee, Eun-Jin Kim, Don-Kyu Kim, Ji-Min Lee, Seung Bum Park, In-Kyu Lee, Robert A. Harris, Mi-Ock Lee, Hueng-Sik Choi
Myeong Seon Jeong, Eunha Kim, Hyo Jin Kang, Eun Joung Choi, Alvin R. Cho, Sang J. Chung, Seung Bum Park
Seung-Hee Chang, Youn-Sun Chung, Soon-Kyung Hwang, Jung-Taek Kwon, Arash Minai-Tehrani, Sunghoon Kim, Seung Bum Park, Yeon-Soo Kim, Myung-Haing Cho
Don-Kyu Kim, Dongryeol Ryu, Minseob Koh, Min-Woo Lee, Donghyun Lim, Min-Jung Kim, Yong-Hoon Kim, Won-Jea Cho, Chul-Ho Lee, Seung Bum Park, Seung-Hoi Koo, Hueng-Sik Choi
Jongmin Park, Sangmi Oh, Seung Bum Park
Byeongju Kim, Donghyun Lim, Hye Jun Jin, Hyang Yeon Lee, Seon Namgung, Yeonjin Ko, Seung Bum Park, Seunghun Hong
Mi Young Cha, Kwang-Ok Lee, Mira Kim, Ji Yeon Song, Kyu Hang Lee, Jongmin Park, Yun Jung Chae, Young Hoon Kim, Kwee Hyun Suh, Gwan Sun Lee, Seung Bum Park, Maeng Sup Kim
Ilseung Yang, Eunha Kim, Junhee Kang, Hyouksoo Han, Soohwan Sul, Seung Bum Park, Seong Keun Kim
Mi Young Cha, Kwang-Ok Lee, Seok-Jong Kang, Young Hee Jung, Ji Yeon Song, Kyung Jin Choi, Joo Yun Byun, Han-Jae Lee, Gwan Sun Lee, Seung Bum Park, Maeng Sup Kim