Synthesis and operation of a nano-demension 24 × 24 × 15 Å3 “left and right ball-joint-type
host-guest system” via one π...π interaction and three NH...O=C hydrogen-bonds along with
the combined helicity are described. The system consists of unprecedented conglomerate
aggregates of two distinct helical metallacyclophanes, chiral isomer (P)-[Pd3X6(L1)2]@(M)-
[Pd3X6(L1)(L2)] and its enantiomer (M)-[Pd3X6(L1)2]@(P)- [Pd3X6(L1)(L2)] are described.
Successive reactions afford desirable four-layered metallacyclophanes via tailor-made
procedure. Synthesis and operation of a nano-demension size multilayered metallacyclophane
system via one π...π interaction along with the combined helicity are described. A synthetic
strategy of generation of new molecular species utilizing a provision of nature has been
reported: nano-dimensional (23(2) × 21(1) × 16(1) Å3) hetero four-layered trimetallacyclophanes
via the proof-of-concept experiments that utilize a suitable combination of π...π
interactions between the central aromatic rings, tailor-made short/long spacer tridentate donors,
and the combined helicity are constructed. The unprecedented four-layered metallacyclophane
system’s behavior offers a landmark in the development of new molecular system.