Large arrays of rationally designed experiments are a powerful tool for solving complex and challenging chemical problems. In this lecture, conceptual and practical aspects of high-throughput experimentation will be presented, followed by recent examples of high-throughput experimentation- enabled reaction discovery, development, and mechanistic elucidation applied to asymmetric hydrogenation with first-row transition metals. Participants will gain an understanding of the strengths and limitations of running large arrays of experiments and an appreciation for the wealth of tools that can be employed to solve their chemistry problems.

Michael Shevlin is an Associate Principal Scientist in the Catalysis Laboratory in the Department of Process Research & Development at MSD. Since joining MSD in 2006, Michael has become the departmental expert in asymmetric hydrogenation through work on over 40 MSD projects. Michael is a passionate advocate of highthroughput experimentation for reaction discovery, development, and mechanistic elucidation, and is the key MSD collaborator working with Professor Paul Chirik at Princeton University to develop base metal asymmetric hydrogenation catalysts. Prior to joining MSD, Michael received his M.S. degree from the University of Illinois-Chicago in 2004 and spent two years teaching at Ivy Tech State College in Lafayette, Indiana.