Targeting Protein-Protein Interactions Using Chemical Tools
소속 :
연사 : Hyun Suk Lim( Postech Chemistry)
일시 : 2012-11-08 17:00 ~
장소 : 500동 목암홀
일 시 : 2012년 11월 8일, 5:00 PM
장 소 : 500동 목암홀
-Abstract-
Protein-protein interactions (PPIs) play a critical role in mediating a wide range of cellular functions, and thus disregulation of PPIs is linked to various disease states. Molecules that can modulate these interactions would be valuable research tools to uncover molecular functions of target proteins and could be potential therapeutic candidates. However, discovering such molecules is considered among the most difficult challenges in chemical biology and drug discovery. Due to the fairly large and flat protein interfaces, typical small ‘drug-like’ molecules may not effectively cover such extended protein contact areas. In this talk, I will present our efforts to develop a novel class of molecules that are suitable to target protein interfaces, thus serving as excellent sources of modulators of PPIs.
장 소 : 500동 목암홀
-Abstract-
Protein-protein interactions (PPIs) play a critical role in mediating a wide range of cellular functions, and thus disregulation of PPIs is linked to various disease states. Molecules that can modulate these interactions would be valuable research tools to uncover molecular functions of target proteins and could be potential therapeutic candidates. However, discovering such molecules is considered among the most difficult challenges in chemical biology and drug discovery. Due to the fairly large and flat protein interfaces, typical small ‘drug-like’ molecules may not effectively cover such extended protein contact areas. In this talk, I will present our efforts to develop a novel class of molecules that are suitable to target protein interfaces, thus serving as excellent sources of modulators of PPIs.
