Designing dynamic surfaces for regulation of biological responses
소속 :
연사 : Dr. Ji-Hun Seo (Tokyo Medical and Dental University)
일시 : 2012-04-06 16:00 ~
장소 : 500동 L301호
일 시 : 2012년 4월 6일, 4:00 PM
장 소 : 500동 L301호
-Abstract-
The state of adsorbed proteins plays a dominant role in most non-specific biological responses such as foreign body reaction or clot formation. Although several applications of anti-fouling materials have been reported for the limited number of available biomaterials such as artificial blood vessels, anti-fouling properties also prevent the promotion of tissue regeneration on the materials implanted in a damaged body. Because the extracellular matrix composed of protein molecules is an essential factor for cell adhesion and tissue formation, protein adsorption on the biomaterials is a fundamental requirement. However, non-specifically adsorbed surface proteins also can trigger undesirable biological reactions as mentioned above. This paradoxical problem of protein adsorption has been a fundamental barrier to the development of ideal biomaterials that prohibit non-specific biological reactions as well as promote specific cell adhesion. We propose that dynamic materials surfaces that flexibly respond to a dynamic biological environment can possibly overcome the limitations of traditional biomaterials. Polyrotaxane (PRX) is a representative molecular assembly consisting of a host molecule, e.g., α-cyclodextrin (α-CD), threading a guest molecule, e.g., linear polyethylene glycol (PEG). Because both components are not covalently connected, the threaded α-CD molecules are anticipated to be movable along with the PEG backbone. Based on this perspective, we have systematically studied the effect of molecular mobility of PRX on biological responses. The aim of this study is to investigate the dynamic interaction of mobile PRX derivatives with protein molecules and the associated biological responses including platelet and cellular adhesion study.
장 소 : 500동 L301호
-Abstract-
The state of adsorbed proteins plays a dominant role in most non-specific biological responses such as foreign body reaction or clot formation. Although several applications of anti-fouling materials have been reported for the limited number of available biomaterials such as artificial blood vessels, anti-fouling properties also prevent the promotion of tissue regeneration on the materials implanted in a damaged body. Because the extracellular matrix composed of protein molecules is an essential factor for cell adhesion and tissue formation, protein adsorption on the biomaterials is a fundamental requirement. However, non-specifically adsorbed surface proteins also can trigger undesirable biological reactions as mentioned above. This paradoxical problem of protein adsorption has been a fundamental barrier to the development of ideal biomaterials that prohibit non-specific biological reactions as well as promote specific cell adhesion. We propose that dynamic materials surfaces that flexibly respond to a dynamic biological environment can possibly overcome the limitations of traditional biomaterials. Polyrotaxane (PRX) is a representative molecular assembly consisting of a host molecule, e.g., α-cyclodextrin (α-CD), threading a guest molecule, e.g., linear polyethylene glycol (PEG). Because both components are not covalently connected, the threaded α-CD molecules are anticipated to be movable along with the PEG backbone. Based on this perspective, we have systematically studied the effect of molecular mobility of PRX on biological responses. The aim of this study is to investigate the dynamic interaction of mobile PRX derivatives with protein molecules and the associated biological responses including platelet and cellular adhesion study.
