Targeting Discoidin Domain Receptor tyrosine kinase as a multiple drug target
소속 :
연사 : 양범석 박사 (KIST)
일시 : 2009-06-24 10:30 ~
장소 : 500동 목암홀
일시: 2009년 6월 24일 오전 10:30
장소: 500동 목암홀
-Abstract-
Discoidin domain receptors which consist of DDR1 and DDR2 belong to receptor tyrosine kinase family. They are non-integrin type cell surface receptor to recognize extracellular matrix protein and become activated by fibrous type collagens. Their signaling is reported to activate fibrotic cells and immune cells and stimulate malignant cancer. We have developed a small molecule inhibitor against discoidin domain receptor tyrosine kinase and examined whether this inhibitor can suppress cancerous phenotypes and fibroinflammation.
장소: 500동 목암홀
-Abstract-
Discoidin domain receptors which consist of DDR1 and DDR2 belong to receptor tyrosine kinase family. They are non-integrin type cell surface receptor to recognize extracellular matrix protein and become activated by fibrous type collagens. Their signaling is reported to activate fibrotic cells and immune cells and stimulate malignant cancer. We have developed a small molecule inhibitor against discoidin domain receptor tyrosine kinase and examined whether this inhibitor can suppress cancerous phenotypes and fibroinflammation.
