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SNU Department of Chemistry
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to Advance Frontiers in Chemistry
SNU Department of Chemistry
Department of Chemistry
Seoul National University
Creative, Collaborative, and Innovative
Seoul National University
화학부 새소식
서울대 화학부 홍승윤·이승훈 교수팀, 고전적 전자-전달 이론의 한계를 벗어난 주족원소 촉매 개발
서울대학교 홍승윤·이승훈 교수 공동 연구팀(제1저자 홍영은)은 이러한 제약에 얽매이지 않는 분자촉매를 개발해, 산화–환원 전위가 맞지 않는 기질 사이의 유기반응을 최초로 구현하는 데 성공했다.
2025-06-15
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대학지성
"아질산염 고부가화·업사이클링 실현" 서울대 이윤호 교수팀, 친환경 코발트 촉매 개발
서울대 화학부 이윤호 교수 연구팀은 삼기능성 코발트 촉매를 통해 아질산염의 업사이클링을 실현하고 친환경 헤테로고리 합성 촉매반응을 이끌어냈다고 30일 밝혔다.
2025-05-30
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이코노미사이언
서울대 송윤주·정택동 교수팀, 글루탐산 감지법 개발
서울대학교 송윤주 교수와 정택동 교수 공동연구팀(제1저자 한민정, 윤선희)이 글루탐산 산화효소(GlutOx)에 금속 착물을 위치 특이적으로 결합시켜, 효소 내부의 전자 흐름 경로를 정밀하게 제어하는 데 성공했다고 31일 밝혔다.
2025-03-31
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이코노미사이언스
서울대 화학부 황윤정 교수팀, 이산화탄소 전환 속도 향상 극대화, 전해질 내 물 역할 조절이 관건
서울대 화학부 황윤정 교수 연구팀과 충남대 신혜영 교수 연구팀은 기존 중성 및 염기성 조건에서 발생하는 이산화탄소 손실 문제를 해결하기 위해 산성 전해질을 적용한 시스템에서 성능 향상의 새로운 전략을 제시하였다고 보고하였다.
2025-03-21
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베리타스 알파
서울대 화학부 강지형 교수팀, 리튬금속 전지용 비발화 고성능 전해질 소재 개발
서울대 화학부(제1저자 장진하 박사 및 강지형 교수 외), UCLA(제1저자 총젠 왕 및 유장 리 교수 외) 및 LG 에너지솔루션 (LG Energy Solution-KAIST Frontier Research Laboratory) 연구진들의 공동연구를 통해 이온성 플라스틱 결정이 주입된 신개념 전해질을 개발할 수 있었다.
2025-03-13
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베리타스 알파
생명의 비대칭성, 클립 모양 분자로 그 기원을 설명하다
서울대학교 화학부 이동환 교수 연구진은 분자 클립을 이용해 생명체의 단일 카이랄성 기원에 대한 중요한 단서를 발견했다.
2025-01-17
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대학지성
서울대·울산대, AI활용 새로운 면역항암 치료용 효소 찾아
서울대학교는 화학부 및 생명과학부, 제약학과 연구진 및 울산대학교 의과대학 및 갤럭스와의 공동연구로 AI를 활용한 면역항암 치료용 효소를 발굴했다고 4일 밝혔다.
2025-01-04
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네이버뉴스
대웅제약, 서울대와 손잡고 내성 극복 독감 치료제 개발 추진
대웅제약은 서울대 화학부 이연 교수 연구팀과 함께 진행하는 '구아니딘 오셀타미비르를 활용한 장기지속형 항바이러스제 개발' 연구가 보건복지부의 감염병 예방·치료 기술개발사업 신규 지원 대상 과제로 선정됐다고 10일 밝혔다.
2024-09-11
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연합뉴스
공지사항 / 세미나
2025 그린바이오 컨소시엄 하계 GREENBIO ACADEMY 프로그램 참가 신청 안내
일반
2025-06-25
그린바이오 컨소시엄 AFPRO 2025 농식품 테크 스타트업 창업 박람회 참가 신청 안내
일반
2025-06-25
[혁신융합대학사업] 2025학년도 2학기 교류수학 안내
수업
2025-06-24
운전면허 적성검사·갱신 대상자 폭증에 따른 신청방법 안내
일반
2025-06-23
07
2025.07
특별세미나 - 안설희 교수 (University of California)
Accelerating free energy exploration using parallelizable Gaussian accelerated molecular dynamics (ParGaMD)
20
2025.06
특별세미나 - Marc Kielmann, Ph.D. (Managing Editor, Beilstein Journal of Organic Chemistry)
Insights into a Journal Editor’s Tool Kit
13
2025.06
특별세미나 - Prof. Oliver S. Wenger (Department of Chemistry, University of Basel, Switzerland)
Designing Photoactive Metal Complexes and Unraveling Mechanisms in Photochemistry
12
2025.06
정규세미나 - 홍정진 (포스코홀딩스 미래기술연구원 에너지소재 연구소장)
이차전지 소재 산업의 기술 개발 동향과 포스코의 도전
05
2025.06
정규세미나 - Prof. Ken Kamikawa (Oska Metropolitan University)
Syntheses and Applications of Non-Central Chiral Molecules: From Planar Chiral Ligands to Helical Polycyclic Aromatic Hydrocarbons
29
2025.05
정규세미나 - 김정곤 교수 (전북대학교)
Constructive Polymer Mechanochemistry - Where we are now
RECENT PUBLICATIONS
Colorimetric detection of cancer biomarker by using porous Mn–N–C single-atom nanozyme with peroxidase-like activity
Glutathione (GSH) is a critical antioxidant in biological systems involved in various cellular processes such as cell proliferation and apoptosis, and is considered as one of the cancer biomarkers. However, the conventional methods for detecting GSH levels often involve complex and time-consuming preparation and sophisticated equipment, posing challenges for rapid and straightforward analysis. Herein, we develop a colorimetric nanosensor using porous single-atom nanozymes (SAzymes), particularly those consisting of atomically dispersed metals on nitrogen-doped carbon supports (M-N-C), to monitor GSH quantitatively. The Mn–N–C SAzymes catalyze the oxidation of 3,3′,5,5′-tetramethylbenzidine (TMB) by hydrogen peroxide (H2O2), resulting in a measurable color change. The high porosity of the Mn–N–C SAzymes offers a large surface area accommodating a high density of accessible active sites for efficient catalysis. The addition of GSH in this system leads to a notable reduction in color intensity, offering an effective method for the quantitative measurement of GSH. The Mn–N–C SAzymes demonstrate high efficacy in the rapid colorimetric detection of GSH, with a low detection limit of 0.70 μM and a broad dynamic range of 0–40 μM. This method is further applied for a simple and rapid colorimetric analysis of the cancer biomarker in various biological samples, including tissues and serum. Demonstrating the potential for diagnostic applications, this approach offers a promising tool for clinical diagnostics, enabling reliable and convenient monitoring of GSH levels, which is crucial for assessing disease progression.
2025-09-01
Direct anodic electrografting of Osmium complexes on Indium tin oxide
Indium tin oxide (ITO) is a widely used electrode material in electrochemical biosensors owing to its beneficial characteristics such as transparency and chemical inertness. The exceptionally sluggish kinetics of heterogeneous electron transfer in ITO provides an exceptionally low background current, making electron mediators essential for electrochemical sensors. However, the chemical modification of ITO with molecular mediators is still challenging. Few straightforward and credible methods are available to obtain sufficiently thin mediator films firmly anchored on the ITO without losing its inherent benefits, including low background current and transparency. This study demonstrated the anodic electrografting of three osmium complexes, which allowed the formation of molecular mediator monolayers on ITO. The densely packed monolayer of osmium complexes retained their reversible redox processes over hundreds of potential cycles. We confirmed electron mediation by the modified electrodes for 4-aminophenol oxidation, suggesting a simple protocol for developing ITO-based biosensors functionalized with molecular mediators.
2025-06-01
Redirecting electron flows in glutamate oxidases by selective anchoring of osmium complexes
L-Glutamate is the most abundant and essential excitatory neurotransmitter in the nervous system. However, its direct electrochemical detection is challenging due to its inherently non-electroactive nature. In this study, we redesigned L-glutamate oxidase (GlutOx) by covalently attaching osmium polypyridyl complexes as electron mediators at selected sites. Most engineered enzymes retained their native catalytic activity, while exhibiting significantly altered catalytic currents during L-glutamate oxidation, depending on the proximity, orientation, and microenvironments of the osmium complexes relative to the FAD cofactors. Notably, two mutants significantly enhanced catalytic currents, revealing selectively and efficiently rerouted electron transfer pathways from the enzyme active site to Os complexes. These findings provide an effective strategy for designing redox-active enzymes for electrochemical biosensors.
2025-05-07
A sustainable strategy to reduce net methane emissions from thermokarst lakes by electrochemical methane partial oxidation
Global warming increases methane emissions from Arctic permafrost, which in turn reaccelerates global warming, creating a vicious cycle. Addressing this issue requires innovative solutions, such as electro-assisted methane partial oxidation (EMPO), which can provide an on-site facility for sustainable methane emission reduction in permafrost. In this study, a Co singe-atom catalyst was synthesized as an oxygen reduction reaction (ORR) catalyst that can be practically applied to stand-alone EMPO systems. To address performance degradation and cold weather freezing due to flooding of the electrodes, the hydrophobic polytetrafluoroethylene was mixed into a catalyst layer to regulate the microenvironment near cathodes. Furthermore, hydrophobic cathodes offer a pathway for nonpolar gases to increase the local concentration of methane. The enhanced local methane concentration, combined with an efficient ORR catalyst, yields 8 mmol gcatsingle bond1 formic acid at a low potential bias. Remarkably, the EMPO system exhibits a consistent production even with air and is highly stable. This leads to possibility of on-site facility for methane conversion without external energy at thermokarst lakes.
2025-05-05
3D-printed device for time- and cost-efficient sample preparation and DNA fractionation
Direct detection of DNA in complex biological samples bears several challenges regarding the selectivity and sensitivity of analyses. Therefore, DNA pre-extraction from bio-fluids is an emerging tool in biologically related fields. Specifically, a newly developing family of liquid biopsy techniques using PCR detection of circulating tumor DNA from blood serum or blood plasma could be significantly improved by harnessing fast and high-throughput DNA sample preparation. To address these needs, a 3D-printed device and a method based on gel electrophoresis combined with electrodialysis for the time-, cost- and labor-efficient preparative separation of DNA fragments from blood was developed. The proposed system also successfully eliminated large DNA fragments from the samples. Recovery for short DNA fragments was reaching up to 80 %. The method was tested on human genomic DNA and blood and blood serum spiked with DNA standards, and it significantly alleviated the signal of matrix DNA.
2025-05-01
Contrasting effects of mismatch locations on Z-DNA formation under bending force
Z-DNA is a non-canonical, left-handed helical structure that plays crucial roles in various cellular processes. DNA mismatches, which involve the incorporation of incorrect Watson–Crick base pairs, are present in all living organisms and contribute to the mechanism of Z-DNA formation. However, the impact of mismatches on Z-DNA formation remains poorly understood. Moreover, the combined effect of DNA mismatches and bending, a common biological phenomenon observed in vivo, has not yet been explored due to technological limitations. Here, using single-molecule FRET, we show that a mismatch inside the Z-DNA region, i.e., the CG repeat region, hinders Z-DNA formation. In stark contrast, however, a mismatch in the B–Z junction facilitates Z-DNA formation. When the bending force is applied on double stranded DNA, a mismatch in the B–Z junction releases the bending stress more effectively than one in the CG repeat region. These findings provide mechanical insights into the role of DNA mismatches and bending forces in regulating Z-DNA formation, whether promoting or inhibiting it in biological environments.
2025-04-21
Excess Cations Alter *CO Intermediate Configuration and Product Selectivity of Cu in Acidic Electrochemical CO2 Reduction Reaction
Concentrated cations are often employed to promote electrochemical CO2 reduction reaction (CO2RR) selectivity in acidic electrolytes. Here, we investigate the influence of excess cations on the *CO adsorption configuration and the product distribution of the CO2RR. Operando attenuated total reflectance surface-enhanced infrared absorption spectroscopy (ATR-SEIRAS) reveals that increasing the Cs+ concentration shifts the preference of the *CO intermediate on the Cu surface from the atop (*COatop) to the bridge (*CObridge) configuration. This transition leads to a sharp decline in C–C coupling and an increase in the hydrogen evolution reaction at high Cs+ concentrations (0.7 and 1.0 M) under acidic conditions. Time-resolved SEIRAS scans show that *COatop is kinetically dominant and the proportion of *CObridge increases gradually only at high cation concentrations. Density functional theory simulations confirm that Cs+ on the Cu surface can interact electrostatically with *CO and stabilize *CObridge over *COatop on the Cu surface. The evolution of *CObridge is also observed on Ag catalysts, indicating that the effect at high concentrations is not limited to Cu. Furthermore, polymeric binders on the Cu surface mitigate these detrimental effects on the CO2RR and restore C2H4 production by preventing the cation from altering the *CO adsorption sites on the catalyst surface. This study provides new insights into the effects of cations on catalyst performance, with implications for catalyst design and operation.
2025-04-16
3D Histology visualizing hypoxia-induced upregulation of N-terminal cysteine using de novo fluorophore generation
Our research group developed a novel fluorescence staining strategy based on the DNFC targeting N-Cys in proteins. By treating biological samples with non-fluorogenic citrate and coupling reagents, we achieved strong cyan fluorescence, enabling effective visualization of N-Cys proteins in cells and tissues. The DNFC reaction occurs specifically on N-Cys residues, making it highly ideal for monitoring protein processing events, particularly within the Arg/N-degron pathway. Under hypoxic conditions, DNFC fluorescence is significantly enhanced, likely due to the increased presence of N-Cys-containing proteins. Using immunoassays and mass spectrometry, we identified Class 2 actin as a target protein under hypoxia, emphasizing the utility of 3D histopathology for analyzing actin's spatial distribution. Furthermore, we have identified a novel finding indicating a significant presence of RGS5 in red blood cells (RBCs), a discovery that has not been previously reported. Our fluorescence imaging studies, conducted across various cell types, animal tissues, and human clinical samples suggest that DNFC staining, when combined with tissue-clearing techniques, enables detailed 3D imaging of N-Cys proteins and may offer a means to assess molecular responses to hypoxia within tissues. This study highlights the potential of DNFC as a valuable tool for imaging and quantitative analysis of N-proteomes and providing a foundation for 3D histopathology in hypoxia-related disease research.
2025-04-01
A First-In-Human Phase 1 Study to Evaluate the Safety and Tolerability of LEM-S401, a Novel siRNA-DegradaBALL Drug Targeting CTGF in Healthy Adults
This study evaluated the safety, tolerability, and pharmacokinetics of LEM-S401, a novel siRNA therapeutic with DegradaBALL, a mesoporous silica nanoparticle-based delivery system. LEM-S401 is designed to deliver siRNA targeting connective tissue growth factor (CTGF) to fibroblasts for treating hypertrophic scars and keloids, both of which result from abnormal collagen proliferation. LEM-S401, containing unmodified siRNA LEM-17234 encapsulated in DegradaBALL nanoparticles, was administered subcutaneously to healthy adults in a randomized, double-blind, placebo-controlled, single-ascending dose study. Safety and tolerability assessments included vital signs, adverse events (AEs), laboratory tests, and cytokine levels. Pharmacokinetic analysis of LEM-17234 and silicon (Si), the primary component of DegradaBALL, was performed using blood samples collected at specified time points. LEM-S401 demonstrated a favorable safety and tolerability profile with only mild, self-resolving injection site reactions including pain and erythema. No systemic AEs were observed, and cytokine levels showed no significant changes between the treatment and placebo groups. Pharmacokinetic analysis revealed that LEM-17234 was below the plasma detection limit, indicating no notable systemic exposure of siRNA, while Si showed no dose-dependent systemic exposure, suggesting minimal systemic circulation of the mesoporous silica nanoparticles. These findings suggest DegradaBALL effectively encapsulates and delivers siRNA locally without significant systemic exposure. The novel DegradaBALL delivery system enables the stable and targeted delivery of siRNA, which presumably overcomes challenges related to siRNA instability and off-target effects. LEM-S401 has the potential to advance the treatment of fibrotic skin diseases such as keloids and hypertrophic scars by delivering siRNA directly to fibroblasts, thereby inhibiting excessive collagen production.
2025-04-01
Development of potential immunomodulatory ligands targeting natural killer T cells inspired by gut symbiont-derived glycolipids
α-Galactosylceramide (α-GalCer) is a prototypical antigen recognized by natural killer T (NKT) cells, a subset of T cells crucial for immune regulation. Despite its significance, the complex structure-activity relationship of α-GalCer and its analogs remains poorly understood, particularly in defining the structural determinants of NKT cell responses. In this study, we designed and synthesized potential immunomodulatory ligands targeting NKT cells, inspired by glycolipids derived from the gut symbiont Bacteroides fragilis. A series of α-GalCer analogs with terminal iso-branched sphinganine backbones was developed through rational modification of the acyl chain. Our results identified the C3′ hydroxyl group as a structural element that impairs glycolipid presentation by CD1d, as evidenced by reduced IL-2 secretion and weak competition with a potent CD1d ligand. Notably, among C3′-deoxy α-GalCer analogs, those containing an α-chloroacetamide group exhibited robust NKT cell activation with Th2 selectivity. Computational docking and mass spectrometry analyses further confirmed the substantial interaction of α-chloroacetamide analogs to CD1d. These findings underscore the potential of leveraging microbiota-derived glycolipid structures to selectively modulate NKT cell functions for therapeutic purposes.
2025-04-01
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