Professor
Park, Seung Bum
Chemical Biology Laboratory
LAB Website
LAB Website
OFFICE
503-522
/
+82-2-880-9090
LAB
503-508,530
/
+82-2-880-4373
E-MAIL sbpark@snu.ac.kr
Research Topic
The main focus of my research is the identification and development of new bioactive chemical properties, which allow us to study the complex biological system as well as to utilize the new properties as potential therapeutic agents (drugs), through interdisciplinary approaches; Organic Chemistry, Bioassay, and Chemical Biology.
Design and synthesis of diverse and complex small molecules through Diversity Oriented Synthesis (DOS)
Development of new high-throughput screening for biological evaluation
Chemical Biology for the Application of identified bioactive small molecules
Design and synthesis of diverse and complex small molecules through Diversity Oriented Synthesis (DOS)
Development of new high-throughput screening for biological evaluation
Chemical Biology for the Application of identified bioactive small molecules
Education
- Ph.D. Chemistry, Texas A&M University, USA, 2001
- M.S. Chemistry, Yonsei University, Korea, 1997
- B.S. Chemistry, Yonsei University, Korea, 1993
Career
- Postdoctoral Research Fellow, Harvard University, 2001-2004
Papers
- “Phenotypic Discovery of Neuroprotective Agents by Regulation of Tau Proteostasis via Stress‐Responsive Activation of PERK Signaling.” Shin, Y.-H.; Cho, H.; Choi, B.Y.; Ha, J.; Kim, J.; Yim, J.; Suh, S.W.; Park, S.B.* Angew. Chem. Int. Ed., 2021 (DOI: 10.1002/anie.202013915) (Cover article).
- “Nature-inspired remodeling of (aza)indoles to meta-aminoaryl nicotinates for late-stage conjugation of vitamin B3 to (hetero)arylamines.” Varun, B.V.†; Vaithegi, K.†; Yi, S.; Park, S.B.* Nature Communications, 2020, 11: 6308.
- “Monochromophoric Design Strategy for Tetrazine-based Colorful Bioorthogonal Probes with a Single Fluorescent Core Skeleton.” Lee, Y.; Cho, W.; Sung, J.; Kim, E.*; Park, S. B.* J. Am. Chem. Soc., 2018, 140, 974–983 (Cover article).
- “Diversity-Oriented Synthetic Strategy for Developing Chemical Modulator of Protein–Protein Interaction.” Kim, J.; Koo, J.; Jung, J.; Cho, W.; Lee, W. S.; Kim, C.; Park, W.; Park, S.B.* Nature Communications, 2016, 7: 13196.
- “Discovery, Understanding, and Bioapplication of Organic Fluorophore: A Case Study with an Indolizine-Based Novel Fluorophore, Seoul-Fluor.” Kim, E.; Lee, Y.; Lee, S.; Park, S.B.* Acc. Chem. Res. 2015, 48(3), 538–547.
- “A Small Molecule Binding HMGB1 and HMGB2 Inhibits Microglia-Mediated Neuroinflammation.” Lee, S.; Nam, Y.; Koo, J.Y.; Lim, D.; Park, J.; Ock, J.; Suk, K.*; Park, S.B.* Nature Chemical Biology 2014 10(12), 1055–1060.
Search Papers
Mi Young Cha, Kwang-Ok Lee, Jong Woo Kim, Chang Gon Lee, Ji Yeon Song, Young Hoon Kim, Gwan Sun Lee, Seung Bum Park, Maeng Sup Kim
Eunha Kim, Seung Bum Park
Yuan-Bin Xie, Jeong-Hoh Park, Don-Kyu Kim, Jung Hwan Hwang, Sangmi Oh, Seung Bum Park, Minho Shong, In-Kyu Lee, Hueng-Sik Choi
Yu Shun Tian, Hyang Yeon Lee, Chang Su Lim, Jongmin Park, Hwan Myung Kim, Yoo Na Shin, Eun Sun Kim, Hoon Jae Jeon, Seung Bum Park, Bong Rae Cho
Yongju Kim, Minseob Koh, Don-Kyu Kim, Hueng-Sik Choi, Seung Bum Park
Soon Young Kim, Jongmin Park, Minseob Koh, Seung Bum Park, Jong-In Hong
Tae Young Kim, Jongmin Park, Bora Oh, Hyun Jung Min, Tae-Sook Jeong, Jae Hoon Lee, Cheolwon Suh, June-Won Cheong, Hyo Jung Kim, Sung-Soo Yoon, Seung Bum Park, Dong Soon Lee
Soon-Kyung Hwang, Hwang-Tae Lim, Arash Minai-Tehrani, Eun-Sun Lee, Jongmin Park, Seung Bum Park, George R. Beck, Jr., Myung-Haing Cho
Sangmi Oh, Koon Soon Kim, Young Sun Chung, Minho Shong, Seung Bum Park
So Ok Park, Jonghoon Kim, Minseob Koh, Seung Bum Park