Professor
Park, Seung Bum
Chemical Biology Laboratory
LAB Website
LAB Website
OFFICE
503-522
/
+82-2-880-9090
LAB
503-508,530
/
+82-2-880-4373
E-MAIL sbpark@snu.ac.kr
Research Topic
The main focus of my research is the identification and development of new bioactive chemical properties, which allow us to study the complex biological system as well as to utilize the new properties as potential therapeutic agents (drugs), through interdisciplinary approaches; Organic Chemistry, Bioassay, and Chemical Biology.
Design and synthesis of diverse and complex small molecules through Diversity Oriented Synthesis (DOS)
Development of new high-throughput screening for biological evaluation
Chemical Biology for the Application of identified bioactive small molecules
Design and synthesis of diverse and complex small molecules through Diversity Oriented Synthesis (DOS)
Development of new high-throughput screening for biological evaluation
Chemical Biology for the Application of identified bioactive small molecules
Education
- Ph.D. Chemistry, Texas A&M University, USA, 2001
- M.S. Chemistry, Yonsei University, Korea, 1997
- B.S. Chemistry, Yonsei University, Korea, 1993
Career
- Postdoctoral Research Fellow, Harvard University, 2001-2004
Papers
- “Phenotypic Discovery of Neuroprotective Agents by Regulation of Tau Proteostasis via Stress‐Responsive Activation of PERK Signaling.” Shin, Y.-H.; Cho, H.; Choi, B.Y.; Ha, J.; Kim, J.; Yim, J.; Suh, S.W.; Park, S.B.* Angew. Chem. Int. Ed., 2021 (DOI: 10.1002/anie.202013915) (Cover article).
- “Nature-inspired remodeling of (aza)indoles to meta-aminoaryl nicotinates for late-stage conjugation of vitamin B3 to (hetero)arylamines.” Varun, B.V.†; Vaithegi, K.†; Yi, S.; Park, S.B.* Nature Communications, 2020, 11: 6308.
- “Monochromophoric Design Strategy for Tetrazine-based Colorful Bioorthogonal Probes with a Single Fluorescent Core Skeleton.” Lee, Y.; Cho, W.; Sung, J.; Kim, E.*; Park, S. B.* J. Am. Chem. Soc., 2018, 140, 974–983 (Cover article).
- “Diversity-Oriented Synthetic Strategy for Developing Chemical Modulator of Protein–Protein Interaction.” Kim, J.; Koo, J.; Jung, J.; Cho, W.; Lee, W. S.; Kim, C.; Park, W.; Park, S.B.* Nature Communications, 2016, 7: 13196.
- “Discovery, Understanding, and Bioapplication of Organic Fluorophore: A Case Study with an Indolizine-Based Novel Fluorophore, Seoul-Fluor.” Kim, E.; Lee, Y.; Lee, S.; Park, S.B.* Acc. Chem. Res. 2015, 48(3), 538–547.
- “A Small Molecule Binding HMGB1 and HMGB2 Inhibits Microglia-Mediated Neuroinflammation.” Lee, S.; Nam, Y.; Koo, J.Y.; Lim, D.; Park, J.; Ock, J.; Suk, K.*; Park, S.B.* Nature Chemical Biology 2014 10(12), 1055–1060.
Search Papers
155. Phenotypic Discovery of SB1501, an Anti‐obesity Agent, through Modulating Mitochondrial Activity
Ala Jo, Mingi Kim, Jong In Kim, Jaeyoung Ha, Yoon Soo Hwang, Hyunsung Nam, Injae Hwang, Jae Bum Kim, Seung Bum Park
Jaeyoung Ha, Hankum Park, Jongmin Park, Seung Bum Park
Young‐Hee Shin, Hana Cho, Bo Young Choi, Jonghoon Kim, Jaeyoung Ha, Sang Won Suh, Seung Bum Park
Hyunwoo Chung, Hyunsung Nam, Thuy Nguyen-Phuong, Jiyun Jang, Sung Ji Hong, So Won Choi, Seung Bum Park, Chung-Gyu Park
Seung Min Kim, Jongmin Park, Myun Soo Kim, Heebum Song, Ala Jo, Hankum Park, Tae Sung Kim, Sang Ho Choi, Seung Bum Park
Jieun Moon, Eunji Kong, Jingu Lee, Jinjoo Jung, Eunha Kim, Seung Bum Park, Pilhan Kim
Young-Hee Shin, Hana Cho, Bo Young Choi, Jonghoon Kim, Jaeyoung Ha, Sang Won Suh, Seung Bum Park
Dahham Kim, Jae-Hong Lee, Ja Young Koo, Hwan Myung Kim, Seung Bum Park
Wan Gi Byun, Donghyun Lim, Seung Bum Park
Hang-Suk Chuna, Seo-Jung Han, Dae-Seop Shin, Haushabhau S.Pagire, Suvarna H.Pagire, Gwi Bin Lee, Chong Hak Chae, Boryeong Pak, Suk-Won Jin, Young-Tae Chang, Seung Bum Park, Jin Hee Ahn, Myung Ae Bae