Associate Professor

Lee, Hyung Ho

Structural Biochemistry Lab
LAB Website
OFFICE 503동 120호 / +82-2-880-4129
LAB 503-108,128 / +82-2-880-4130

Research Topic

Membrane receptors and channels represent the gateway through which the cell senses and responds to its environment. Most physiologically important processes are initiated by the interaction of cell-surface receptors/channels with extracellular mediators. This recognition event is communicated across the membrane, resulting in activation of intracellular signal transduction cascades. We ask how information is transmitted across the cell membrane at the molecular level.

It is easy to agree that "Seeing is believing". The roots of our research are in the power of x-ray crystallography and cryo-EM to reveal the structures of biomolecules at atomic level, leading to insights in the physical basis of protein-protein interactions. The core approach is complemented by studies in solution or on membranes by hydrodynamics, small angle x-ray scattering, fluorescence imaging, and various biophysical tools. The structural, biochemical, and biophysical experiments lead to new hypotheses about biological function and mechanism. We also try to demonstrate our new hypotheses in cells using various cell biological tools.

Structures of drug target proteins can also be used to discover new lead compounds by structure-based drug discovery (SBDD) method. We are interested in various drug target proteins to treat various diseases including cancer.


  • Ph.D. Chemistry, Seoul National University, Korea, 2007
  • M.S. Chemistry, Seoul National University, Korea, 2002
  • B.S. Food Science and Biotechnology, Seoul National University, Korea, 2000


  • Assistant Professor, Department of Bio & Nano Chemistry, Kookmin University, 2010-2014
  • Postdoctoral Fellow, NIDDK, National Institutes of Health, USA, 2007-2010
  • Postdoctoral Researcher, The Research Institute of Basic Sciences, Seoul National University, 2007-2007


  1. Min, K.; An, D. R.; Yoon, H. J.; Rana, N.; Park, J. S.; Kim, J.; Lee, M.; Hesek, D.; Ryu, S.; Kim, B. M.; Mobashery, S.; Suh, S. W.; Lee, H. H. Peptidoglycan reshaping by a noncanonical peptidase for helical cell shape in Campylobacter jejuni. Nat. Commun. 2020, 11 (1), 458.
  2. Kim, M.; Kim, H. J.; Son, S. H.; Yoon, H. –J.; Lim, Y.; Lee, J. W.; Seok, Y. –J.; Jin, K. S.; Yu, Y. G.; Kim, S. K.; Ryu, S.; Lee, H. H. Non-canonical DNA binding mode of repressor and its disassembly by anitrepressor. Proc. Natl. Acad. Sci. USA 2016, 113 (18), E2480-2488.
  3. Lee, W. K.; Son, S. H.; Jin, B. S.; Na, J. H.; Kim, S. Y.; Kim, E. K.; Yu, Y. G.; Lee, H. H. Structural and functional insights into the regulation mechanism of CK2 by IP6 and the intrinsically disordered protein Nopp140. Proc. Natl. Acad. Sci. USA 2016, 110 (48), 19360-19365.
  4. Kim, H. J.; Yoon, J.; Matsuura, A.; Na, J. H.; Lee, W. K.; Kim, H.; Choi, J. W.; Park, J. E.; Park, S. J.; Kim, K.; Chang, R.; Lee, B. I.; Yu, Y. G.; Shin, Y. K.; Jeong, C.; Rhee, K.; Lee, H. H. Structural and biochemical insights into the role of TEX14 in forming the stable intercellular bridges of germ cells. Proc. Natl. Acad. Sci. USA 2015, 112 (40), 12372-12377.
  5. Lee, H. H.; Elia, N.; Ghirlando, R.; Lippincott-Schwartz, J.; Hurley, J. H. Midbody targeting of the ESCRT machinery by a noncanonical coiled coil in CEP55. Science 2008, 322 (5901), 576-580.
  6. Lee, H. H.; Kim, Y. S.; Kim, K. H.; Heo, I.; Kim, S. K.; Kim, O.; Kim, H. K.; Yoon, J. Y.; Kim, H. S.; Kim, D. J.; Lee, S. J.; Yoon, H. J.; Kim, S. J.; Lee, B. G.; Song, H. G.; Kim, V. N.; Park, C. M.; Suh, S. W. Structural and functional insight into Dom34, a key component of No-Go mRNA decay. Mol. Cell 2007, 27 (6), 938-950.

Search Papers

Seu-Na Lee, Hwa-Jin Cho, Hyeongseop Jeong, Bumhan Ryu, Hyuk-Joon Lee, Minsoo Kim, Jejoong Yoo, Jae-Sung Woo, Hyung Ho Lee
Nature Communications, 2023, 14, (2023-03-11) Link
Suk Min Kim, Jinhee Lee, Sung Heuck Kang, Yoonyoung Heo, Hye-Jin Yoon, Ji-Sook Hahn, Hyung Ho Lee, Yong Hwan Kim
Nature Catalysis, 2022, 5, (2022-09-01) Link
Hye-Jin Yoon, Yeeun Lee, Jian Jeong, Soonmin Jang, Hyung Ho Lee, Gap-Sue Kim
Journal of the Chinese Chemical Society, 2022, (2022-08-22) Link
Yuri Choi, Yongyang Luo, Seunghwa Lee, Hanyong Jin, Hye-Jin Yoon, Yoonsoo Hahn, Jeehyeon Bae, Hyung Ho Lee
Nucleic Acids Research, 2022, (2022-08-03) Link
Yuri Choi, Ji Su Park, Jinshil Kim, Kyungjin Min, Kiran Mahasenan, Choon Kim, Hye-Jin Yoon, Sewon Lim, Dae Hee Cheon, Yan Lee, Sangryeol Ryu, Shahriar Mobashery, B. Moon Kim, Hyung Ho Lee
Communications Biology, 2022, 395, (2022-04-28) Link
Jungyoon Ohn, Kyung Wook Been, Jin Yong Kim, Eun Ju Kim, Taeyong Park, Hye‐Jin Yoon, Jeong Seok Ji, Miki Okada‐Iwabu, Masato Iwabu, Toshimasa Yamauchi, Yeon Kyung Kim, Chaok Seok, Ohsang Kwon, Kyu Han Kim, Hyung Ho Lee, Jin Ho Chung
EMBO molecular medicine, 2021, 13, 10, (2021-10-07) Link
ByeongJin Cho, Jaejun Choi, RyeongHyeon Kim, Jean Nyoung Yun, Yuri Choi, Hyung Ho Lee, Junseock Koh
Journal of the American Chemical Society, 2021, 143, 32, (2021-08-18) Link
Jongdae Won, Yuri Choi, Yaejin Yun, Hyung Ho Lee
Molecules and Cells, 2021, 44, 4, (2021-04-30) Link
Dong Gyun Kim, Kyu Yeon Lee, Sang Jae Lee, Seung Ho Cheon, Yuri Choi, Hyung Ho Lee, Hee Chul Ahn, Bong Jin Lee
Structural Biology, 2021, D77, (2021-04-14) Link