Faculty

DEPARTMENT OF CHEMISTRY, SEOUL NATIONAL UNIVERSITY.

Associate Professor

Lee, Hyung Ho

Structural Biochemistry Lab
LAB Website
OFFICE 503동 120호 / +82-2-880-4129
LAB 503-108,128 / +82-2-880-4130
RESEARCH AREAS

Research Topic

Membrane receptors and channels represent the gateway through which the cell senses and responds to its environment. Most physiologically important processes are initiated by the interaction of cell-surface receptors/channels with extracellular mediators. This recognition event is communicated across the membrane, resulting in activation of intracellular signal transduction cascades. We ask how information is transmitted across the cell membrane at the molecular level.

It is easy to agree that "Seeing is believing". The roots of our research are in the power of x-ray crystallography and cryo-EM to reveal the structures of biomolecules at atomic level, leading to insights in the physical basis of protein-protein interactions. The core approach is complemented by studies in solution or on membranes by hydrodynamics, small angle x-ray scattering, fluorescence imaging, and various biophysical tools. The structural, biochemical, and biophysical experiments lead to new hypotheses about biological function and mechanism. We also try to demonstrate our new hypotheses in cells using various cell biological tools.

Structures of drug target proteins can also be used to discover new lead compounds by structure-based drug discovery (SBDD) method. We are interested in various drug target proteins to treat various diseases including cancer.

Education

  • Ph.D. Chemistry, Seoul National University, Korea, 2007
  • M.S. Chemistry, Seoul National University, Korea, 2002
  • B.S. Food Science and Biotechnology, Seoul National University, Korea, 2000

Career

  • Assistant Professor, Department of Bio & Nano Chemistry, Kookmin University, 2010-2014
  • Postdoctoral Fellow, NIDDK, National Institutes of Health, USA, 2007-2010
  • Postdoctoral Researcher, The Research Institute of Basic Sciences, Seoul National University, 2007-2007

Papers

  1. Min, K.; An, D. R.; Yoon, H. J.; Rana, N.; Park, J. S.; Kim, J.; Lee, M.; Hesek, D.; Ryu, S.; Kim, B. M.; Mobashery, S.; Suh, S. W.; Lee, H. H. Peptidoglycan reshaping by a noncanonical peptidase for helical cell shape in Campylobacter jejuni. Nat. Commun. 2020, 11 (1), 458.
  2. Kim, M.; Kim, H. J.; Son, S. H.; Yoon, H. –J.; Lim, Y.; Lee, J. W.; Seok, Y. –J.; Jin, K. S.; Yu, Y. G.; Kim, S. K.; Ryu, S.; Lee, H. H. Non-canonical DNA binding mode of repressor and its disassembly by anitrepressor. Proc. Natl. Acad. Sci. USA 2016, 113 (18), E2480-2488.
  3. Lee, W. K.; Son, S. H.; Jin, B. S.; Na, J. H.; Kim, S. Y.; Kim, E. K.; Yu, Y. G.; Lee, H. H. Structural and functional insights into the regulation mechanism of CK2 by IP6 and the intrinsically disordered protein Nopp140. Proc. Natl. Acad. Sci. USA 2016, 110 (48), 19360-19365.
  4. Kim, H. J.; Yoon, J.; Matsuura, A.; Na, J. H.; Lee, W. K.; Kim, H.; Choi, J. W.; Park, J. E.; Park, S. J.; Kim, K.; Chang, R.; Lee, B. I.; Yu, Y. G.; Shin, Y. K.; Jeong, C.; Rhee, K.; Lee, H. H. Structural and biochemical insights into the role of TEX14 in forming the stable intercellular bridges of germ cells. Proc. Natl. Acad. Sci. USA 2015, 112 (40), 12372-12377.
  5. Lee, H. H.; Elia, N.; Ghirlando, R.; Lippincott-Schwartz, J.; Hurley, J. H. Midbody targeting of the ESCRT machinery by a noncanonical coiled coil in CEP55. Science 2008, 322 (5901), 576-580.
  6. Lee, H. H.; Kim, Y. S.; Kim, K. H.; Heo, I.; Kim, S. K.; Kim, O.; Kim, H. K.; Yoon, J. Y.; Kim, H. S.; Kim, D. J.; Lee, S. J.; Yoon, H. J.; Kim, S. J.; Lee, B. G.; Song, H. G.; Kim, V. N.; Park, C. M.; Suh, S. W. Structural and functional insight into Dom34, a key component of No-Go mRNA decay. Mol. Cell 2007, 27 (6), 938-950.

Search Papers

Sang Hyeon Son, Hyung Ho Lee
Acta Crystallographica Section F - Structural Biology Communications, 2015, 71, 2, (2015-02-01) Link
Sun-Ki Kim, Yong-Cheol Park, Hyung Ho Lee, Seung Taeg Jeon, Won-Ki Min, Jin-Ho Seo
Biotechnology and Bioengineering, 2015, 112, 2, (2015-02-01) Link
Hyunjun Choe, Jung Min Ha, Jeong Chan Joo, Hyunook Kim, Hye-Jin Yoon, Seonghoon Kim, Sang Hyeon Son, Robert M. Gengan, Seung Taeg Jeon, Rakwoo Chang, Kwang Deog Jung, Yong Hwan Kim, Hyung Ho Lee
Acta Crystallographica Section D - Biological Crystallography, 2015, 71, 2, (2015-02-01) Link
Won-Kyu Lee, Sang Hyeon Son, Bong-Suk Jin, Jung-Hyun Na, Soo-Youl Kim, Kook-Han Kim, Eunice EunKyeong Kim, Yeon Gyu Yu, Hyung Ho Lee
Proceedings of the National Academy of Sciences of the United States of America, 2013, 110, 48, (2013-11-26) Link
Atsushi Matsuura, Hyung Ho Lee
Biochemical and Biophysical Research Communications, 2013, 435, 3, (2013-06-07) Link
Sang Hyeon Son, Hyung Ho Lee
Biochemical and Biophysical Research Communications, 2013, 433, 1, (2013-03-29) Link
Seong-Gu Han, Won-Kyu Lee, Bong-Suk Jin, Ki-In Lee, Hyung Ho Lee, Yeon Gyu Yu
Journal of Microbiology and Biotechnology, 2013, 23, 3, (2013-03-28) Link
Sang Taek Jung, Hyung Ho Lee
Acta Crystallographica Section F - Structural Biology Communications, 2013, 69, 2, (2013-02-01) Link
Atsushi Matsuura, Ji Young Yoon, Hye-Jin Yoon, Hyung Ho Lee, Se Won Suh
Molecules and Cells, 2012, 34, 4, (2012-10-31) Link
Sang Hyeon Son, Dong Yun Lee, Ye Jun Kim, Sooho Ko, Seong Jun Cho, Hyo Cheol Jung, Hyung Ho Lee
Korean Journal of Microbiology and Biotechnology, 2012, 40, 3, (2012-09-28) Link