In the eukaryotic nucleus, DNA wraps around histone octamers to form nucleosomes. The nucleic acids and histones frequently undergo chemical modifications, and these modifications influence overall chromatin structure to regulate DNA-dependent processes including transcription, replication, DNA repair and recombination in living organisms. Our primary research goal is to understand fundamental mechanisms of chromatin-based gene regulation. We study how distinct chromatin modifications coordinate with each other and how various chromatin factors are recruited to chromatin to translate epigenetic information into gene expression. Furthermore, information and function of a genome are not only decorated with epigenetic marks in the linear DNA sequence but also in their non-random spatial organization in the nucleus. We also aim to extend our understanding of dynamic coupling between 3D chromatin organization and epigenetic regulation.

• Ph.D. Department of Chemistry, Seoul National University, Korea, 2010
• B.S. Department of Plant Science, Seoul National University, Korea, 2005

• Postdoctoral Researcher, Seoul National University, Korea, 2010-2011
• Postdoctoral Researcher, Max Planck Institute for Chemical Ecology, Germany, 2011-2012
• Assistant Professor, Chonbuk National University, Korea, 2012-2016
• Associate Professor, Sungkyunkwan University, Korea, 2016-2018
• Associate Professor, Seoul National University, Korea, 2018-present

1. “MYB96 Recruits the HDA15 Protein to Suppress Negative Regulators of ABA Signaling in Arabidopsis.” H. G. Lee, and P. J. Seo, Nat. Commun. 2019, 10, 1713.
2. “Dynamic Epigenetic Changes during Plant Regeneration.” K. Lee, and P. J. Seo, Trend Plant Sci. 2018, 23, 235-247.
3. “Arabidopsis ATXR2 Deposits H3K36me3 at the Promoters of LBD Genes to Facilitate Cellular Dedifferentiation” K. Lee, O. S. Park, and P. J. Seo. Sci. Signal. 2017,10, eaan0316.
4. “The Arabidopsis MIEL1 E3 Ligase Negatively Regulates ABA Signaling by Promoting Protein Turnover of MYB96.” H. G. Lee, and P. J. Seo. Nat. Commun. 2016, 7, 12525.
5. “Multiple Layers of Posttranslational Regulation Refine Circadian Clock Activity in Arabidopsis.” P. J. Seo, and P. Mas. Plant Cell 2014, 26, 79-87.
6. “Two Splice Variants of the IDD14 Transcription Factor Competitively Form Nonfunctional Heterodimers Which May Regulate Starch Metabolism.” P. J. Seo, M. J. Kim, J. Y. Ryu, E. Y. Jeong, and C. M. Park. Nat. Commun. 2011, 2, 303.