Park, Seung Bum

 Chemical Biology Laboratory
LAB Website
OFFICE 503-522 / +82-2-880-9090
LAB 503-508,530 / +82-2-880-4373

Research Topic

The main focus of my research is the identification and development of new bioactive chemical properties, which allow us to study the complex biological system as well as to utilize the new properties as potential therapeutic agents (drugs), through interdisciplinary approaches; Organic Chemistry, Bioassay, and Chemical Biology.

Design and synthesis of diverse and complex small molecules through Diversity Oriented Synthesis (DOS)

Development of new high-throughput screening for biological evaluation

Chemical Biology for the Application of identified bioactive small molecules


  • Ph.D. Chemistry, Texas A&M University, USA, 2001
  • M.S. Chemistry, Yonsei University, Korea, 1997
  • B.S. Chemistry, Yonsei University, Korea, 1993


  • Postdoctoral Research Fellow, Harvard University, 2001-2004


  1. “Phenotypic Discovery of Neuroprotective Agents by Regulation of Tau Proteostasis via Stress‐Responsive Activation of PERK Signaling.” Shin, Y.-H.; Cho, H.; Choi, B.Y.; Ha, J.; Kim, J.; Yim, J.; Suh, S.W.; Park, S.B.* Angew. Chem. Int. Ed., 2021 (DOI: 10.1002/anie.202013915) (Cover article).
  2. “Nature-inspired remodeling of (aza)indoles to meta-aminoaryl nicotinates for late-stage conjugation of vitamin B3 to (hetero)arylamines.” Varun, B.V.†; Vaithegi, K.†; Yi, S.; Park, S.B.* Nature Communications, 2020, 11: 6308.
  3. “Monochromophoric Design Strategy for Tetrazine-based Colorful Bioorthogonal Probes with a Single Fluorescent Core Skeleton.” Lee, Y.; Cho, W.; Sung, J.; Kim, E.*; Park, S. B.* J. Am. Chem. Soc., 2018, 140, 974–983 (Cover article).
  4. “Diversity-Oriented Synthetic Strategy for Developing Chemical Modulator of Protein–Protein Interaction.” Kim, J.; Koo, J.; Jung, J.; Cho, W.; Lee, W. S.; Kim, C.; Park, W.; Park, S.B.* Nature Communications, 2016, 7: 13196.
  5. “Discovery, Understanding, and Bioapplication of Organic Fluorophore: A Case Study with an Indolizine-Based Novel Fluorophore, Seoul-Fluor.” Kim, E.; Lee, Y.; Lee, S.; Park, S.B.* Acc. Chem. Res. 2015, 48(3), 538–547.
  6. “A Small Molecule Binding HMGB1 and HMGB2 Inhibits Microglia-Mediated Neuroinflammation.” Lee, S.; Nam, Y.; Koo, J.Y.; Lim, D.; Park, J.; Ock, J.; Suk, K.*; Park, S.B.* Nature Chemical Biology 2014 10(12), 1055–1060.

Search Papers

Junhyeong Yim, Jaeseok Lee, Sihyeong Yi, Ja Young Koo, Sangmi Oh, Hankum Park, Seong Soon Kim, Myung Ae Bae, Jongmin Park, Seung Bum Park
Experimental & Molecular Medicine, 2022, 54, (2022-12-12) Link
Hyun-Jin Jang, Yae Jin Yoon, Jiyeon Choi, Yu-Jin Lee, Sangku Lee, Wansang Cho, Wan Gi Byun, Seung Bum Park, Dong Cho Han, Byoung-Mog Kwon
Pharmaceuticals, 2022, 15, 12, (2022-11-25) Link
Yun Lim Jung, Sourav Sarkar, Jaeyoung Ha, Seung Bum Park, Kyo Han Ahn
Bioconjugate Chemistry, 2022, 33, 8, (2022-08-17) Link
Wan Gi Byun, Donghyun Lim, Seung Bum Park
Current Opinion in Chemical Biology, 2022, 68, (2022-06-01) Link
Youngjun Lee, Dahham Kim, Seung Bum Park
Chemistry - A European Journal, 2022, 28, 30, (2022-05-25) Link
Young-Hee Shin, Kiyoung Jeong, Jihye Lee, Hyo Jung Lee, Junhyeong Yim, Jonghoon Kim, Seungtaek Kim, Seung Bum Park
Angewandte Chemie International Edition, 2022, 61, 11, (2022-03-07) Link
Sungwhan F. Oh, T. Praveena, Heebum Song, Ji-Sun Yoo, Da-Jung Jung, Deniz Erturk-Hasdemir, Yoon Soo Hwang, ChangWon C. Lee, Jérôme Le Nours, Hyunsoo Kim, Jesang Lee, Richard S. Blumberg, Jamie Rossjohn, Seung Bum Park, Dennis L. Kasper
Nature, 2021, 600, (2021-11-10) Link