Park, Seung Bum

 Chemical Biology Laboratory
LAB Website
OFFICE 503-522 / +82-2-880-9090
LAB 503-508,530 / +82-2-880-4373

Research Topic

The main focus of my research is the identification and development of new bioactive chemical properties, which allow us to study the complex biological system as well as to utilize the new properties as potential therapeutic agents (drugs), through interdisciplinary approaches; Organic Chemistry, Bioassay, and Chemical Biology.

Design and synthesis of diverse and complex small molecules through Diversity Oriented Synthesis (DOS)

Development of new high-throughput screening for biological evaluation

Chemical Biology for the Application of identified bioactive small molecules


  • Ph.D. Chemistry, Texas A&M University, USA, 2001
  • M.S. Chemistry, Yonsei University, Korea, 1997
  • B.S. Chemistry, Yonsei University, Korea, 1993


  • Postdoctoral Research Fellow, Harvard University, 2001-2004


  1. “Phenotypic Discovery of Neuroprotective Agents by Regulation of Tau Proteostasis via Stress‐Responsive Activation of PERK Signaling.” Shin, Y.-H.; Cho, H.; Choi, B.Y.; Ha, J.; Kim, J.; Yim, J.; Suh, S.W.; Park, S.B.* Angew. Chem. Int. Ed., 2021 (DOI: 10.1002/anie.202013915) (Cover article).
  2. “Nature-inspired remodeling of (aza)indoles to meta-aminoaryl nicotinates for late-stage conjugation of vitamin B3 to (hetero)arylamines.” Varun, B.V.†; Vaithegi, K.†; Yi, S.; Park, S.B.* Nature Communications, 2020, 11: 6308.
  3. “Monochromophoric Design Strategy for Tetrazine-based Colorful Bioorthogonal Probes with a Single Fluorescent Core Skeleton.” Lee, Y.; Cho, W.; Sung, J.; Kim, E.*; Park, S. B.* J. Am. Chem. Soc., 2018, 140, 974–983 (Cover article).
  4. “Diversity-Oriented Synthetic Strategy for Developing Chemical Modulator of Protein–Protein Interaction.” Kim, J.; Koo, J.; Jung, J.; Cho, W.; Lee, W. S.; Kim, C.; Park, W.; Park, S.B.* Nature Communications, 2016, 7: 13196.
  5. “Discovery, Understanding, and Bioapplication of Organic Fluorophore: A Case Study with an Indolizine-Based Novel Fluorophore, Seoul-Fluor.” Kim, E.; Lee, Y.; Lee, S.; Park, S.B.* Acc. Chem. Res. 2015, 48(3), 538–547.
  6. “A Small Molecule Binding HMGB1 and HMGB2 Inhibits Microglia-Mediated Neuroinflammation.” Lee, S.; Nam, Y.; Koo, J.Y.; Lim, D.; Park, J.; Ock, J.; Suk, K.*; Park, S.B.* Nature Chemical Biology 2014 10(12), 1055–1060.

Search Papers

Junhyeong Yim, Yoon Soo Hwang, Jae-Jin Lee, Ju Hee Kim, Jeong Yeob Baek, Jaeyeong Jeong, Young Il Choi, Byung Kwan Jind, Seung Bum Park
Chemical Science, 2024, 15, 10, (2024-02-02) Link
Dahham Kim, Hayoung Son, Seung Bum Park
Hana Cho, Bo Young Choi, Young-Hee Shin, Sang Won Suh, Seung Bum Park
ACS Chemical Neuroscience, 2023, 14, 23, (2023-12-06) Link
Wansang Cho, Jung Ho Lee, Seung Bum Park
FUTURE MEDICINAL CHEMISTRY, 2023, 15, 20, (2023-10-01) Link
Kannan Vaithegi, Sihyeong Yi, Ji Hyae Lee, Begur Vasanthkumar Varun, Seung Bum Park
Communications Chemistry, 2023, 6, 112, (2023-06-07) Link
Dr. Wansang Cho, Solchan Won, Dr. Yoona Choi, Dr. Sihyeong Yi, Jong Beom Park, Dr. Jun-Gyu Park, Caroline E. Kim, Dr. Chintam Narayana, Ju Hee Kim, Dr. Junhyeong Yim, Dr. Young Il Choi, Prof. Dong-Sup Lee, Seung Bum Park
Angewandte Chemie International Edition, 2023, 62, 16, (2023-04-24) Link
Si-jie Dai, Yu-ying Shao, Yang Zheng, Jin-yi Sun, Zhi-sheng Li, Jia-ying Shi, Meng-qi Yan, Xiao-yun Qiu, Ceng-lin Xu, Wan-sang Cho, Masahiro Nishibori, Sihyeong Yi, Seung Bum Park, Yi Wang, Zhong Chen
Acta Pharmacologica Sinica, 2023, 44, (2023-04-23) Link
Jinjoo Jung, Jongbeom Park, Mingi Kim, Jaeyoung Ha, Hana Cho, Seung Bum Park
Communications Biology, 2023, 6, 1, (2023-03-21) Link
Junhyeong Yim, Jaeseok Lee, Sihyeong Yi, Ja Young Koo, Sangmi Oh, Hankum Park, Seong Soon Kim, Myung Ae Bae, Jongmin Park, Seung Bum Park
Experimental & Molecular Medicine, 2022, 54, (2022-12-12) Link