Associate Professor
Lee, Hyung Ho
Structural Biochemistry Lab
LAB Website
LAB Website
OFFICE
503동 120호
/
+82-2-880-4129
LAB
503-108,128
/
+82-2-880-4130
E-MAIL hyungholee@snu.ac.kr
RESEARCH AREAS
Research Topic
Membrane receptors and channels represent the gateway through which the cell senses and responds to its environment. Most physiologically important processes are initiated by the interaction of cell-surface receptors/channels with extracellular mediators. This recognition event is communicated across the membrane, resulting in activation of intracellular signal transduction cascades. We ask how information is transmitted across the cell membrane at the molecular level.
It is easy to agree that "Seeing is believing". The roots of our research are in the power of x-ray crystallography and cryo-EM to reveal the structures of biomolecules at atomic level, leading to insights in the physical basis of protein-protein interactions. The core approach is complemented by studies in solution or on membranes by hydrodynamics, small angle x-ray scattering, fluorescence imaging, and various biophysical tools. The structural, biochemical, and biophysical experiments lead to new hypotheses about biological function and mechanism. We also try to demonstrate our new hypotheses in cells using various cell biological tools.
Structures of drug target proteins can also be used to discover new lead compounds by structure-based drug discovery (SBDD) method. We are interested in various drug target proteins to treat various diseases including cancer.
It is easy to agree that "Seeing is believing". The roots of our research are in the power of x-ray crystallography and cryo-EM to reveal the structures of biomolecules at atomic level, leading to insights in the physical basis of protein-protein interactions. The core approach is complemented by studies in solution or on membranes by hydrodynamics, small angle x-ray scattering, fluorescence imaging, and various biophysical tools. The structural, biochemical, and biophysical experiments lead to new hypotheses about biological function and mechanism. We also try to demonstrate our new hypotheses in cells using various cell biological tools.
Structures of drug target proteins can also be used to discover new lead compounds by structure-based drug discovery (SBDD) method. We are interested in various drug target proteins to treat various diseases including cancer.
Education
- Ph.D. Chemistry, Seoul National University, Korea, 2007
- M.S. Chemistry, Seoul National University, Korea, 2002
- B.S. Food Science and Biotechnology, Seoul National University, Korea, 2000
Career
- Assistant Professor, Department of Bio & Nano Chemistry, Kookmin University, 2010-2014
- Postdoctoral Fellow, NIDDK, National Institutes of Health, USA, 2007-2010
- Postdoctoral Researcher, The Research Institute of Basic Sciences, Seoul National University, 2007-2007
Papers
- Min, K.; An, D. R.; Yoon, H. J.; Rana, N.; Park, J. S.; Kim, J.; Lee, M.; Hesek, D.; Ryu, S.; Kim, B. M.; Mobashery, S.; Suh, S. W.; Lee, H. H. Peptidoglycan reshaping by a noncanonical peptidase for helical cell shape in Campylobacter jejuni. Nat. Commun. 2020, 11 (1), 458.
- Kim, M.; Kim, H. J.; Son, S. H.; Yoon, H. –J.; Lim, Y.; Lee, J. W.; Seok, Y. –J.; Jin, K. S.; Yu, Y. G.; Kim, S. K.; Ryu, S.; Lee, H. H. Non-canonical DNA binding mode of repressor and its disassembly by anitrepressor. Proc. Natl. Acad. Sci. USA 2016, 113 (18), E2480-2488.
- Lee, W. K.; Son, S. H.; Jin, B. S.; Na, J. H.; Kim, S. Y.; Kim, E. K.; Yu, Y. G.; Lee, H. H. Structural and functional insights into the regulation mechanism of CK2 by IP6 and the intrinsically disordered protein Nopp140. Proc. Natl. Acad. Sci. USA 2016, 110 (48), 19360-19365.
- Kim, H. J.; Yoon, J.; Matsuura, A.; Na, J. H.; Lee, W. K.; Kim, H.; Choi, J. W.; Park, J. E.; Park, S. J.; Kim, K.; Chang, R.; Lee, B. I.; Yu, Y. G.; Shin, Y. K.; Jeong, C.; Rhee, K.; Lee, H. H. Structural and biochemical insights into the role of TEX14 in forming the stable intercellular bridges of germ cells. Proc. Natl. Acad. Sci. USA 2015, 112 (40), 12372-12377.
- Lee, H. H.; Elia, N.; Ghirlando, R.; Lippincott-Schwartz, J.; Hurley, J. H. Midbody targeting of the ESCRT machinery by a noncanonical coiled coil in CEP55. Science 2008, 322 (5901), 576-580.
- Lee, H. H.; Kim, Y. S.; Kim, K. H.; Heo, I.; Kim, S. K.; Kim, O.; Kim, H. K.; Yoon, J. Y.; Kim, H. S.; Kim, D. J.; Lee, S. J.; Yoon, H. J.; Kim, S. J.; Lee, B. G.; Song, H. G.; Kim, V. N.; Park, C. M.; Suh, S. W. Structural and functional insight into Dom34, a key component of No-Go mRNA decay. Mol. Cell 2007, 27 (6), 938-950.
Search Papers
Jun Yong Ha, Ji Young Min, Su Kyung Lee, Hyoun Sook Kim, Do Jin Kim, Kyoung Hoon Kim, Hyung Ho Lee, Hye Kyung Kim, Hye-Jin Yoon, Se Won Suh
Hyung Ho Lee, Ji Young Yoon, Hyoun Sook Kim, Ji Yong Kang, Kyoung Hoon Kim, Do Jin Kim, Jun Yong Ha, Bunzo Mikami, Hye Jin Yoon, Se Won Suh
Jun Yong Ha, Ji Hyun Lee, Kyoung Hoon Kim, Do Jin Kim, Hyung Ho Lee, Hye-Kyung Kim, Hye-Jin Yoon, Se Won Suh
Acta Crystallographica Section F - Structural Biology Communications, 2006, 62, 2, (2006-02-01) Link
Do Jin Kim, Kyoung Hoon Kim, Hyung Ho Lee, Sang Jae Lee, Jun Yong Ha, Hye Jin Yoon, Se Won Suh
Kyoung Hoon Kim, Hyung Jun Ahn, Do Jin Kim, Hyung Ho Lee, Jun-Yong Ha, Hye-Kyung Kim, Hye-Jin Yoon, Se Won Suh
Acta Crystallographica Section F - Structural Biology Communications, 2005, 61, 10, (2005-10-01) Link
Hyung Jun Ahn, Kyoung Hoon Kim, Jiah Lee, Jun-Yong Ha, Hyung Ho Lee, Dojin Kim, Hye-Jin Yoon, Ae-Ran Kwon, Se Won Suh
Hyung Ho Lee, Do Jin Kim, Hyung Jun Ahn, Jun Yong Ha, Se Won Suh
Hye-Lee Kim, Hye-Jin Yoon, Jun Yong Ha, Byung Il Lee, Hyung Ho Lee, Bunzo Mikami, Se Won Suh
Hyung-Wook Kim, Byung Woo Han, Hye-Jin Yoon, Jin Kuk Yang, Byung Il Lee, Hyung Ho Lee, Hyung Jun Ahn, Se Won Suh
Hyung Ho Lee, Jungmin Yun, Jinho Moon, Byung Woo Han, Byung Il Lee, Jae Young Lee, Se Won Suh