Professor
Seok, Chaok
Computational Biology Laboratory
LAB Website
LAB Website
OFFICE
502-223
/
+82-2-880-9197
LAB
502-203
/
+82-2-880-4355
E-MAIL chaok@snu.ac.kr
Research Topic
Our ultimate goal is to understand detailed mechanisms underlying biological phenomena using computational and theoretical tools, and to contribute to curing diseases using the knowledge obtained from such studies. We are currently developing mathematical and computational techniques to model and to simulate biomolecules more efficiently and accurately. An example is an analytical loop closure method that can be used to model flexibilities in proteins loops and cyclic peptides. We will apply these methods to prediction of protein structures and biomolecular interactions, and also extend such experiences to design of new drugs and proteins.
Education
- Ph.D. Chemistry, University of Chicago, USA, 1998
- M.S. Chemistry, University of Chicago, USA, 1995
- B.S. Chemistry, Seoul National University, Korea, 1993
Career
- Research Associate, University of Chicago, 1999
- Research Associate, Massachusetts Institute of Technology, 2000
- Research Associate, University of California, San Francisco, 2000-2004
Papers
- J. Yang, S. Kwon, S.-H. Bae, K. M. Park, C. Yoon, J.-H. Lee, and C. Seok, GalaxySagittarius: Structure- and Similarity-Based Prediction of Protein Targets for Druglike Compounds, J. Chem. Inf. Model, 60 (6), 3246-3254 (2020).
- J. Yang, M. Baek, and C. Seok, GalaxyDock3: Protein-ligand docking that considers the full ligand conformational flexibility, J. Comput. Chem. 40 (31), 2739-2748 (2019).
- J. Won, G. R. Lee, H. Park, and C. Seok, GalaxyGPCRloop: Template-Based and Ab Initio Structure Sampling of the Extracellular Loops of G-Protein-Coupled Receptors, J. Chem. Inf. Model, 58 (6), 1234-1243 (2018).
- G. R. Lee and C. Seok, Galaxy7TM: Flexible GPCR-ligand docking by structure refinement, Nucleic Acids Res. 44 (W1), W502-506 (2016).
- H. Park, H. Lee, and C. Seok, High-resolution Protein-protein Docking by Global Optimization: Recent Advances and Future Challenges, Current Opinion in Structural Biology, 35, 24-31 (2015).
- H. Lee, L. Heo, M. S. Lee, and C. Seok, GalaxyPepDock: a protein-peptide docking tool based on interaction similarity and energy optimization, Nucleic Acids Res. 43 (W1), W431-W435 (2015).
Search Papers
Injin Bang, Hee Ryung Kim, Andrew H. Beaven, Jinuk Kim, Seung-Bum Ko, Gyu Rie Lee, Hasup Lee, Wonpil Im, Chaok Seok, Ka Young Chung, Hee-Jung Choi
Proceedings of the National Academy of Sciences of the United States of America, 2018, 115, 35, (2018-08-28) Link
Chen Keasar, Liam J. McGufn, Chaok Seok, 외69명, Silvia N. Crivelli
Jonghun Won, Gyu Rie Lee, Hahnbeom Park, Chaok Seok
Gyu Rie Lee, Lim Heo, Chaok Seok
Marc F. Lensink, Sameer Velankar, Minkyung Baek, Lim Heo, Chaok Seok, Shoshana J. Wodak
Xiangqiang Shao, Hyunook Kang, Timothy Loveless, Gyu Rie Lee, Chaok Seok, William I. Weis, Hee-Jung Choi, Jeff Hardin
Qifang Xu, Qingling Tang, Panagiotis Katsonis, Olivier Lichtarge, David Jones, Samuele Bovo, Giulia Babbi, Pier L. Martelli, Rita Casadio, Gyu Rie Lee, Chaok Seok, Aron W. Fenton, Roland L. Dunbrack Jr
Minkyung Baek, Woong‑Hee Shin, Hwan Won Chung, Chaok Seok
Minkyung Baek, Taeyong Park, Lim Heo, Chiwook Park, Chaok Seok
Hansup Lee, Minkyung Baek, Gyu Rie Lee, Sangwoo Park, Chaok Seok