My research group tackles the challenge of understanding how drugs work at the molecular level through a uniquely integrated approach that combines chemical reporter technologies with state-of-the-art chemoproteomics. Chemical reporters—based on fluorescence, optical, and chemiluminescence platforms—allow us to monitor enzyme activity states, quantify target protein abundance, and visualize biochemical changes in living systems with high temporal and spatial resolution. These functional readouts reveal when and how molecular events unfold in response to small-molecule intervention. Chemoproteomics complements this by delivering a proteome-wide map of direct and indirect drug–protein interactions in their native context, enabling precise identification of both on- and off-target effects. Together, these complementary strategies create an exceptionally powerful framework for elucidating drug mechanisms, validating therapeutic targets, and uncovering new biology that drives the discovery of next-generation therapeutics.

• Ph.D. Organic Chemistry, New York University, USA, 2009
• B.S. Chemistry, POSTECH, Korea, 2005

• Associate Professor, School of Transdisplinary Innivation, Seoul National University, 2025 - present
• Associate Professor, Korea University College of Medicine, 2021-2025
• Assistant/Associate Professor, KIST School UST, 2013-2021
• Principal/Senior/Researcher, Korea Institute of Science and Technology, 2010-2021

1. "Chemical proteomics for a comprehensive understanding of functional activity and the interactome.", Kozoriz, K; Lee, J. S.* Chem. Soc. Rev., 2025, 54, 6186-6207.
2. "Disaggregation-Activated pan-COX Imaging Agents for Human Soft Tissue Sarcoma" Hong, K. T.; Park S. B.; Murale, D. P.; Lee, J. H.; Hwang, J.; Jang, W. Y.*; Lee, J. S.* Angew. Chem. Int. Ed., 2024, 63(24), e202405525
3. "Multifunctional Photo-Cross-linking Probes: From Target Protein Searching to Imaging Applications" Kozoriz, K; Shkel, O; Hong, K. T.; Kim, D. H.; Kim, Y. K.; Lee, J. S.* Acc. Chem. Res., 2023, 56(1), 25-36.
4. "Orthogonally-Tunable and ER-Targeting Fluorophores Detect Avian Influenza Virus Early Infection" Kang, T.; Haque, M. M.; Lee, B.; Hong, K. T.; Hong, S. C.; Kim, Y.; Lee, J.; Lee, J. S.*; Lee, D.* Nat. Commun., 2022, 13. 5841.
5. "Targeted Degradation of Transcription Co-activator SRC-1 through the N-Degron Pathway" Lee, Y.; Heo, J.; Jeong, H.; Hong, K. T.; Kwon, D. H.; Shin, M. H.; Oh, M.; Sable, G. A.; Ahn, G. O; Lee, J. S.*; Song, H. K. *; Lim, H. S.* Angew. Chem. Int. Ed., 2020, 59,17548-17555.
6. "Discrimination of Avian Influenza Virus using Host-cell Infection Fingerprinting by Sulfinate-based Fluorescence Superoxide Probe" Hong, S. C.; Murale, D. P.; Jang, S. Y.; Haque, M. M.; Seo, M.; Lee, S.; Woo, D. H.; Kwon,J.; Song, C. S.; Kim, Y. K.; Lee, J. S.* Angew. Chem. Int. Ed., 2018, 57, 9716-9721.