Associate Professor

Kim, Seokhee

Laboratory of Biomolecular Diversity
LAB Website
OFFICE 503-222 / +82-2-880-4123
LAB 503-202 / +82-2-880-4124

Research Topic

We are interested in understanding the molecular logic by which Nature generates the diversity of biomolecules and applying the acquired knowledge and tools to the problems of biotechnology and medicine. Biomolecular diversity in many levels underlies not only the complexity of biological systems, but the adaptation and evolution of organisms in a new environment. The living organisms, therefore, have developed sophisticated mechanisms to generate and manipulate diverse biomolecules. For example, bacteria and fungi synthesize a vast number of structurally-diverse secondary metabolites (or natural products) by elegantly-organized biosynthetic processes, and mammalian immune system handles enormous number of different antibodies via a multitude of controlled genetic and cellular processes. Our research aims at dissecting various aspects of biomolecular diversity generation, and exploiting these Nature’s processes for practical applications.


  • Ph.D. Chemistry and Chemical Biology, Harvard University, USA, 2008
  • B.S. Chemistry, Seoul National Univerity, Seoul, Korea, 2001


  • Assistant/Associate Professor, Department of Chemistry, Seoul National University, Korea, 2014-present
  • Postdoctoral Associate/Fellow, MIT, USA, 2008-2013


  1. Eom, G.; Lee, H.; Kim, S. Development of a genome-targeting mutator for the adaptive evolution of microbial cells. Nucleic Acids Res. 2022, 50(7), e38
  2. Song, I.; Kim, Y.; Yu, J.; Go, S.Y.; Lee, H.G.; Song, W.J.; Kim, S. Molecular mechanism underlying substrate recognition of the peptide macrocyclase PsnB. Nature Chemical Biology, 2021, 17(11), 1123–1131.
  3. Park, H.; Kim, S. Gene-specific mutagenesis enables rapid continuous evolution of enzymes in vivo. Nucleic Acids Res. 2021, 49(6), e32.
  4. Cho, H.; Choi, Y.; Min, K.; Son, J. B.; Park, H.; Lee, H. H.; Kim, S. Over-Activation of a Nonessential Bacterial Protease DegP as an Antibiotic Strategy. Commun. Biol. 2020, 3 (1), 547.
  5. Lee, H.; Choi, M.; Park, J.-U.; Roh, H.; Kim, S. Genome Mining Reveals High Topological Diversity of ω-Ester-Containing Peptides and Divergent Evolution of ATP-Grasp Macrocyclases. J. Am. Chem. Soc. 2020, 142 (6), 3013–3023.

Search Papers

Hyunbin Lee, Sho Hee Park, Jiyoon Kim, Jaehak Lee, Min Sun Koh, Jung Ho Lee, Seokhee Kim
Advanced Science, 2023, (2023-11-20) Link
Hyunsung Nam, Joon Soo An, Jaepil Lee, Yonghwan Yun, Hyunbin Lee, Hyungou Park, Yousung Jung, Ki-Bong Oh, Dong-Chan Oh, Seokhee Kim
Journal of the American Chemical Society, 2023, 145, 40, (2023-10-11) Link
Joon Soo An, Hyunbin Lee, Hyungyu Kim, Seungyeon Woo, Hyunsung Nam, Jayho Lee, Dr. Ji Yun Lee, Prof. Sang-Jip Nam, Prof. Sang Kook Lee, Prof. Ki-Bong Oh, Seokhee Kim, Prof. Dong-Chan Oh
Angewandte Chemie International Edition, 2023, 62, 26, (2023-06-26) Link
Daeje Seo, Bonghyun Koh, Ga-eul Eom, Hye Won Kim, Seokhee Kim
Nucleic Acids Research, 2023, 51, 10, (2023-06-09) Link
Rosana S Molina, Gordon Rix, Amanuella A Mengiste, Beatriz Álvarez, Daeje Seo, Haiqi Chen, Juan E Hurtado, Qiong Zhang, Jorge Donato García-García, Zachary J Heins, Patrick J Almhjell, Frances H Arnold, Ahmad S Khalil, Andrew D Hanson, John E Dueber, David V Schaffer, Fei Chen, Seokhee Kim, Luis Ángel Fernández, Matthew D Shoulders, Chang C Liu
Nature Reviews Methods Primers, 2022, 2, 1, (2022-05-19) Link
Hyunjin Cho, Hyunbin Lee, Kyungtae Hong, Hannah Chung, Inseok Song, Jun-Seok Lee, Seokhee Kim
Biochemistry, 2022, 61, 3, (2022-02-01) Link
Ga-eul Eom, Hyunbin Lee, Seokhee Kim
Nucleic Acids Research, 2021, 50, 7, (2021-12-20) Link
Inseok Song, Younghyeon Kim, Jaeseung Yu, Su Yong Go, Hong Geun Lee, Woon Ju Song, Seokhee Kim
Nature Chemical Biology, 2021, 17, (2021-09-02) Link
Hyojin Park, Seokhee Kim
Nucleic Acids Research, 2021, 49, 6, (2021-01-06) Link
Manuel Montalban-L ´ opez, Thomas A. Scott, Sangeetha Ramesh, Imran R. Rahman, Auke J. van Heel, Jakob H. Viel, Vahe Bandarian, Elke Dittmann, Olga Genilloud, Yuki Goto, Mar´ıa Jose Grande Burgos, Colin Hill, Seokhee Kim, Jesko Koehnke, John A. Latham, A. James Link, Beatriz Mart´ınez, Satish K. Nair, Yvain Nicolet, Sylvie Rebuffat, Hans-Georg Sahl, Dipti Sareen, Eric W. Schmidt, Lutz Schmitt, Konstantin Severinov, Roderich D. Sussmuth, Andrew W. Truman, Huan Wang, Jing-Ke Weng, Gilles P. van Wezel, Qi Zhang, Jin Zhong, Jorn Piel, Douglas A. Mitchell, Oscar P. Kuipers, Wilfred A. van der Donk
Natural Product Reports, 2021, 38, (2021-01-01) Link