화학부교수

DEPARTMENT OF CHEMISTRY, SEOUL NATIONAL UNIVERSITY.

부교수

김성연 Kim, Sung-Yon

신경회로연구실
LAB Website
OFFICE 105-209 / 02-880-4996
LAB 105-209 / 02-880-4994
RESEARCH AREAS

연구내용

In our laboratory, we aim to understand how the brain receives sensory information from both within and outside the body, integrates the multiple streams of information, and generates appropriate behavioral responses. We want to find the mechanistic explanations for how it all begins, how it all ends, and everything in-between.

To achieve this ambitious goal, we focus on innate survival behaviors — such as ingestion, thermoregulation, and aggression — as these behaviors and the underlying brain regions are evolutionarily well-conserved and thus amenable for investigation in rodents. These robust behaviors can be triggered or moderated by sensory stimuli (e.g. touch, heat, and pheromones) that can be experimentally controlled in a precise and quantitative manner, permitting relatively facile identification and parametric characterization of the sensory neural pathways. With the solid knowledge of the sensory afferent circuits, we systematically deconstruct the neural circuitry underlying the integration of sensory information and generation of behavioral and physiological responses. We also seek to answer how these mechanisms become dysregulated in metabolic and affective disorders, such as obesity and depression.

Towards these problems, we employ an arsenal of cutting-edge techniques such as optogenetics, chemogenetics, deep-brain calcium imaging, as well as single-cell RNA-seq. In addition, we develop and use new tools that enable the extraction of structural and molecular information from biological tissues, which helps to reveal the anatomical organization of specific neural circuits in exquisite detail.

학력

  • Stanford University 2009 – 2013 Ph.D. in Neurosciences, Deisseroth Laboratory
  • Seoul National University 2003 – 2009 B.S. in Chemistry and Biological Sciences (double major), summa cum laude (2004 – 2005) Military service in South Korea

주요 경력

  • Korea Brain Research Institute 2020 – present Adjunct Researcher
  • Seoul National University 2017 – present Assistant Professor, Department of Chemistry Institute of Molecular Biology and Genetics
  • Seoul National University 2015 – 2017 Assistant Professor, Department of Biophysics and Chemical Biology Institute of Molecular Biology and Genetics
  • Massachusetts Institute of Technology 2013 – 2015 Postdoctoral Fellow, Institute for Medical Engineering and Science, Chung Laboratory

주요 논문

  1. Tye, K. M.; Prakash, R.; Kim, S.-Y.; Fenno, L. E.; Grosenick, L.; Zarabi, H.; Thompson, K. R.; Gradinaru, V.; Ramakrishnan, C.; Deisseroth, K. Amygdala Circuitry Mediating Reversible and Bidirectional Control of Anxiety. Nature 2011, 471 (7338), 358–362. *Equal contribution
  2. Kim, S.-Y.; Adhikari, A.; Lee, S. Y.; Marshel, J. H.; Kim, C. K.; Mallory, C. S.; Lo, M.; Pak, S.; Mattis, J.; Lim, B. K.; Malenka, R. C.; Warden, M. R.; Neve, R.; Tye, K. M.; Deisseroth, K. Diverging Neural Pathways Assemble a Behavioural State from Separable Features in Anxiety. Nature 2013, 496 (7444), 219–223.
  3. Kim, S.-Y.; Cho, J. H.; Murray, E.; Bakh, N.; Choi, H.; Ohn, K.; Ruelas, L.; Hubbert, A.; McCue, M.; Vassallo, S. L.; Keller, P. J.; Chung, K. Stochastic Electrotransport Selectively Enhances the Transport of Highly Electromobile Molecules. Proc. Natl. Acad. Sci. U. S. A. 2015, 112 (46), E6274-6283.
  4. Park, H.-E.; Choi, D.; Park, J. S.; Sim, C.; Park, S.; Kang, S.; Yim, H.; Lee, M.; Kim, J.; Pac, J.; Rhee, K.; Lee, J.; Lee, Y.; Lee, Y.; Kim, S.-Y. Scalable and Isotropic Expansion of Tissues with Simply Tunable Expansion Ratio. Adv. Sci. 2019, 6 (22), 1901673.
  5. Kim, D.-Y.; Heo, G.; Kim, M.; Kim, H.; Jin, J. A.; Kim, H.-K.; Jung, S.; An, M.; Ahn, B. H.; Park, J. H.; Park, H.-E.; Lee, M.; Lee, J. W.; Schwartz, G. J.; Kim, S.-Y. A Neural Circuit Mechanism for Mechanosensory Feedback Control of Ingestion. Nature 2020, 580 (7803), 376–380.
  6. Lee, S.; Kim, S.; Koo, D.-J.; Yu, J.; Cho, H.; Lee, H.; Song, J. M.; Kim, S.-Y.; Min, D.-H.; Jeon, N. L. 3D Microfluidic Platform and Tumor Vascular Mapping for Evaluating Anti-Angiogenic RNAi-Based Nanomedicine. ACS Nano 2020. *Co-correspondence

논문 검색

Jungho Ahn, Da-Hyun Kim, Dong-Jun Koo, Jungeun Lim, Tae-Eun Park, Jungseub Lee, Jihoon Ko, Seongchan Kim, Minjae Kim, Kyung-Sun Kang, Dal-Hee Min, Sung-Yon Kim, YongTae Kim, Noo Li Jeon
Acta Biomaterialia, 2023, 165, 153-167, (2023-07-15) Link
Myungmo An, Hyun-Kyung Kim, Hoyong Park, Kyunghoe Kim, Gyuryang Heo, Han-Eol Park, ChiHye Chung, Sung-Yon Kim
Experimental Neurobiology, 2022, 31, 6, 376-389, (2022-12-31) Link
Jinyoung Pac, Dong-Jun Koo, Hyeongjun Cho, Dongwook Jung, Min-ha Choi, Yunjung Choi, Bohyun Kim, Ji-Ung Park, Sung-Yon Kim, Yan Lee
Science advances, 2022, 8, 46, eadd9419, (2022-11-16) Link
Minyoo Kim, Gyurang Heo, Sung-Yon Kim
Nature Reviews Neuroscience, 2022, 23, pages135–156, (2022-01-04) Link
Sieun Jung, Myungsun Lee, Dong-Yoon Kim, Celine Son, Benjamin Hyunju Ahn, Gyuryang Heo, Junkoo Park, Minyoo Kim, Han-Eol Park, Dong-Jun Koo, Jong Hwi Park, Jung Weon Lee, Han Kyoung Choe, Sung-Yon Kim
Neuron, 2021, 110, 2, 266-279, (2022-01-19) Link
Somin Lee, Seongchan Kim, Dong-Jun Koo, James Yu, Hyeongjun Cho, Hyojin Lee, Joon Myong Song, Sung-Yon Kim, Dal-Hee Min, Noo Li Jeon
ACS Nano, 2021, 15, 1, 338-350, (2021-1-26) Link
Ann-Na Cho, Yoonhee Jin, Yeonjoo An, Jin Kim, Yi Sun Choi, Jung Seung Lee, Junghoon Kim, Won-Young Choi, Dong-Jun Koo, Weonjin Yu, Gyeong-Eon Chang, Dong-Yoon Kim, Sung-Hyun Jo, Jihun Kim, Sung-Yon Kim, Yun-Gon Kim, Ju Young Kim, Nakwon Choi, Eunji Cheong, Young-Joon Kim, Hyunsoo Shawn Je, Hoon-Chul Kang, Seung-Woo Cho
Nature Communications, 2021, 12, 4730, (2021-08-05) Link
Sunah Kang, Sohyun Park, Hojoon Song, Dongkil Choi, Han-Eol Park, Benjamin H. Ahn, Sung-Yon Kim, Yan Lee
ACS Applied Materials & Interfaces, 2021, 13, 24, 28962-28974, (2021-06-10) Link
Dong-Jun Koo, Jinahn Choi, Minchul Ahn, Benjamin H.Ahn, Dal-Hee Min, Sung-Yon Kim
Bioconjugate Chemistry, 2020, 31, 7, 1784-1794, (2020-07-15) Link