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Building on tradition soaring into the future
SNU Department of Chemistry
Provide basic chemistry through lectures and experiments
SNU Department of Chemistry
Department of Chemistry
Seoul National University
Central, useful, and creative science
SNU Department of Chemistry
Department of Chemistry
Seoul National University
CHEMISTRY NEWS
2024-01-01
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Nano Letters
2023-12-18
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매일경제
2023-12-11
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SCIENCE chosun
2023-10-27
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베리타스 알파
2023-09-05
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동아사이언스
2023-11-09
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연합뉴스
2023-04-11
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베리타스 알파
2023-07-12
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ChosunBiz
SEMINARS
02
2024.05
- Prof. Sungjee Kim (POSTECH)
Nanoclusters and Quantum Dots
18
2024.04
- Prof. Sang Kyu Kim (Department of Chemistry, KAIST )
Nonadiabatic Reaction Dynamics of Polyatomic Molecules (or Anions): Role of the Electron in the (Non)Valence Orbitals
11
2024.04
- Oc Hee Han (Korea Basic Science Institute)
Investigation of Electrochemical Systems and Their Constituents by NMR Spectroscopy
04
2024.04
- Prof. Jeong-Mo Choi (Department of Chemistry, Pusan National University)
Rational Design of Amyloid Aggregation Inhibitors
28
2024.03
- Prof. Minkyung Baek (Department of Biological Sciences, Seoul National University)
Protein structure modeling and design using AI
21
2024.03
- Prof. YounJoon Jung (Department of Chemistry, Seoul National University)
Statistical Mechanics of Space-Time: Trajectory Ensemble Approach
RECENT PUBLICATIONS
Small is Beautiful: Electronic Origin and Synthetic Evolution of Single-Benzene Fluorophores
Single-benzene fluorophores (SBFs) are small molecules that produce visible light by using only one benzene ring as the sole aromatic core. This Account centers around the chemistry of a new class of SBF that we accidentally discovered but rationally developed and refined afterward. In a failed experiment that took an unintended reaction pathway, we encountered the bright green fluorescence of ortho-diacetylphenylenediamine (o-DAPA). Despite its uninspiring look, reminiscent of textbook examples of simple benzene derivatives, this molecule had neither been synthesized nor isolated before. This discovery led to our studies on the larger DAPA family, including isomeric m-DAPA and p-DAPA. Remarkably, p-DAPA is the lightest red fluorophore, with a molecular weight of only 192. While o- and p-DAPA are emissive, m-DAPA rapidly undergoes internal conversion, facilitated by sequential proton transfer reactions in the excited state.
2024-01-02
Exploring the Diverse Landscape of Biaryl-Containing Peptides Generated by Cytochrome P450 Macrocyclases
Cytochrome P450 enzymes (P450s) catalyze diverse oxidative cross-coupling reactions between aromatic substrates in the natural product biosynthesis. Specifically, P450s install distinct biaryl macrocyclic linkages in three families of ribosomally synthesized and post-translationally modified peptides (RiPPs). However, the chemical diversity of biaryl-containing macrocyclic RiPPs remains largely unexplored. Here, we demonstrate that P450s have the capability to generate diverse biaryl linkages on RiPPs, collectively named “cyptides”. Homology-based genome mining for P450 macrocyclases revealed 19 novel groups of homologous biosynthetic gene clusters (BGCs) with distinct aromatic residue patterns in the precursor peptides. Using the P450-modified precursor peptides heterologously coexpressed with corresponding P450s in Escherichia coli, we determined the NMR structures of three novel biaryl-containing peptides─the enzymatic products, roseovertin (1), rubrin (2), and lapparbin (3)─and confirmed the formation of three unprecedented or rare biaryl linkages: Trp C-7′-to-His N-τ in 1, Trp C-7′-to-Tyr C-6 in 2, and Tyr C-6-to-Trp N-1′ in 3. Biochemical characterization indicated that certain P450s in these pathways have a relaxed substrate specificity. Overall, our studies suggest that P450 macrocyclases have evolved to create diverse biaryl linkages in RiPPs, promoting the exploration of a broader chemical space for biaryl-containing peptides encoded in bacterial genomes.
2023-10-11
Energy material analysis via in-situ/operando scanning transmission x-ray microscopy: A review
The development of advanced energy systems is essential for replacing fossil fuel-based societies, and progress in the fundamental understanding of solid-state energy materials has revolutionized this field. In particular, investigating the inhomogeneity of reactions in energy systems requires analysis at the level of individual particles, which are the smallest units in the system. Synchrotron-based scanning transmission X-ray microscopy (STXM) is a valuable tool for exploring reaction and degradation mechanisms, and providing nanoscale site-specific information on chemical and structural changes within single particles. In-situ/operando STXM is particularly useful for observing reactions under well-controlled conditions in real time, thus providing insights into local phenomena obscured by the ensemble effect. This review highlights the research achievements of in-situ/operando STXM in the field of energy materials and provides perspectives for advanced X-ray imaging techniques that can further enhance STXM capabilities.
20230-07-01
Dual Function of N-Iodosuccinimide for C(sp3)−B Bond Activation
A practical method for C(sp3)–B bond activation was developed. Using a combination of alkyl trifluoroborates and N-iodosuccinimide (NIS), various C(sp3)–heteroatom bonds were readily generated in an efficient manner. Mechanistic studies revealed the bifunctional ability of NIS: mediating the formation of reactive halogenated intermediates and activating them via halogen bonding. This electrophilic activation of the reaction center enables the utilization of general heteroatom nucleophiles, which are used in a limited capacity in traditional 1,2-metalate rearrangements.
2023-12-28
Long-Range SECCM Enables High-Throughput Electrochemical Screening of High Entropy Alloy Electrocatalysts at Up-To-Industrial Current Densities
High-entropy alloys (HEAs), especially in the form of compositional complex solid solutions (CCSS), have gained attention in the field of electrocatalysis. However, exploring their vast composition space concerning their electrocatalytic properties imposes significant challenges. Scanning electrochemical cell microscopy (SECCM) offers high-speed electrochemical analysis on surface areas with a lateral resolution down to tens of nm. However, high-precision piezo positioners often used for the motion of the tip limit the area of SECCM scans to the motion range of the piezo positioners which is typically a few tens of microns. To bridge this experimental gap, the study proposes a long-range SECCM system with a rapid gas-exchange environmental cell for high-throughput electrochemical characterization of 100 mm diameter HEA thin-film material libraries (ML) obtained by combinatorial co-sputtering. Due to the gas–liquid interface at the positioned SECCM droplet on the sample, high-throughput evaluation under industrial current density conditions becomes feasible. This allows the direct correlation between electrocatalytic activity and material composition with high statistical reliability. The multidimensional data obtained accelerates materials discovery, development, and optimization.
2023-12-28
Glucose-mediated mitochondrial reprogramming by cholesterol export at TM4SF5-enriched mitochondria-lysosome contact sites
Background Transmembrane 4 L six family member 5 (TM4SF5) translocates subcellularly and functions metabolically, although it is unclear how intracellular TM4SF5 translocation is linked to metabolic contexts. It is thus of interests to understand how the traffic dynamics of TM4SF5 to subcellular endosomal membranes are correlated to regulatory roles of metabolisms. Methods Here, we explored the metabolic significance of TM4SF5 localization at mitochondria-lysosome contact sites (MLCSs), using in vitro cells and in vivo animal systems, via approaches by immunofluorescence, proximity labelling based proteomics analysis, organelle reconstitution etc. Results Upon extracellular glucose repletion following depletion, TM4SF5 became enriched at MLCSs via an interaction between mitochondrial FK506-binding protein 8 (FKBP8) and lysosomal TM4SF5. Proximity labeling showed molecular clustering of phospho-dynamic-related protein I (DRP1) and certain mitophagy receptors at TM4SF5-enriched MLCSs, leading to mitochondrial fission and autophagy. TM4SF5 bound NPC intracellular cholesterol transporter 1 (NPC1) and free cholesterol, and mediated export of lysosomal cholesterol to mitochondria, leading to impaired oxidative phosphorylation but intact tricarboxylic acid (TCA) cycle and β-oxidation. In mouse models, hepatocyte Tm4sf5 promoted mitophagy and cholesterol transport to mitochondria, both with positive relations to liver malignancy. Conclusions Our findings suggested that TM4SF5-enriched MLCSs regulate glucose catabolism by facilitating cholesterol export for mitochondrial reprogramming, presumably while hepatocellular carcinogenesis, recapitulating aspects for hepatocellular carcinoma metabolism with mitochondrial reprogramming to support biomolecule synthesis in addition to glycolytic energetics.
2023-12-22
Unlocking the Potential of Sub-Nanameter Pd Catalysts for Electrochemical Hydrogen Peroxide Production
The utilization of nanoscale catalysts represents a valuable and promising strategy for augmenting catalytic performance while mitigating the reliance on expensive noble metals. Nevertheless, a significant knowledge gap persists regarding the intricate interplay between catalyst size, physical properties, and catalytic behavior in the context of the oxygen reduction reaction. In this study, the synthesis of precisely controlled palladium catalysts is presented, spanning a wide range from individual atoms to metal clusters and nanoparticles, followed by a comprehensive evaluation of their performance in acidic conditions. The results show a significant increase in H2O2 selectivity of up to 96% with decreasing catalyst size and strategic approaches are identified to eliminate unselective sites, facilitating the attainment of active and selective catalysts. The enhanced selectivity of the catalysts highlights the potential of single atom catalytic sites and can be adapted to improve the performance of various catalytic processes.
2023-12-22
Ultrafluorogenic Monochromophore-Type BODIPY-Tetrazine Series for Dual-Color Bioorthogonal Imaging with a Single Probe
Various fluorogenic probes utilizing tetrazine (Tz) as a fluorescence quencher and bioorthogonal reaction partner have been extensively studied over the past few decades. Herein, we synthesized a series of boron-dipyrromethene (BODIPY)-Tz probes using monochromophoric design strategy for bioorthogonal cellular imaging. The BODIPY-Tz probes exhibited excellent bicyclo[6.1.0]nonyne (BCN)-selective fluorogenicity with three- to four-digit-fold enhancements in fluorescence over a wide range of emission wavelengths, including the far-red region. Furthermore, we demonstrated the applicability of BODIPY-Tz probes in bioorthogonal fluorescence imaging of cellular organelles without washing steps. We also elucidated the aromatized pyridazine moiety as the origin of BCN-selective fluorogenic behavior. Additionally, we discovered that the fluorescence of the trans-cyclooctene (TCO) adducts was quenched in aqueous media via photoinduced electron transfer (PeT) process. Interestingly, we observed a distinctive recovery of the initially quenched fluorescence of BODIPY-Tz-TCO upon exposure to hydrophobic media, accompanied by a significant bathochromic shift of its emission wavelength relative to that exhibited by the corresponding BODIPY-Tz-BCN. Leveraging this finding, for the first time, we achieved dual-color bioorthogonal cellular imaging with a single BODIPY-Tz probe.
2023-12-21
3D Microprinting of Inorganic Porous Materials by Chemical Linking-Induced Solidification of Nanocrystals
Three-dimensional (3D) microprinting is considered a next-generation manufacturing process for the production of microscale components; however, the narrow range of suitable materials, which include mainly polymers, is a critical issue that limits the application of this process to functional inorganic materials. Herein, we develop a generalised microscale 3D printing method for the production of purely inorganic nanocrystal-based porous materials. Our process is designed to solidify all-inorganic nanocrystals via immediate dispersibility control and surface linking-induced interconnection in the nonsolvent linker bath and thereby creates multibranched gel networks. The process works with various inorganic materials, including metals, semiconductors, magnets, oxides, and multi-materials, not requiring organic binders or stereolithographic equipment. Filaments with a diameter of sub-10 μm are printed into designed complex 3D microarchitectures, which exhibit full nanocrystal functionality and high specific surface areas as well as hierarchical porous structures. This approach provides the platform technology for designing functional inorganics-based porous materials.
2023-12-20
Reassessing the intrinsic hydrogen evolution reaction activity of platinum using scanning electrochemical cell microscopy
While promising catalysts are constantly being discovered for the electrochemical hydrogen evolution reaction (HER), none have surpassed platinum’s performance, despite its intrinsic activity being underestimated. A thorough assessment of intrinsic activity is therefore necessary to understand platinum’s superior performance. Here, we use scanning electrochemical cell microscopy to overcome limitations in proton and hydrogen mass transport at multiple scales. Reliable HER current transients with steady-state limiting current densities far above the exchange current density are recorded (jl of 4 A/cm2 with a 440 nm pipette) in acid electrolyte. Furthermore, exchange current density analysis shows that platinum’s intrinsic activity (230 ± 34 mA/cm2) is over 200-fold higher than reported in rotating disc measurements (1 mA/cm2), 3-fold higher than the H2 pump method (75 mA/cm2), and almost twice that from micropolarization analysis (140 mA/cm2). These findings demonstrate the importance of mass transport in achieving high-current-density electrocatalysis and reveal platinum’s underestimated intrinsic activity.
2023-12-20
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