NMR spectroscopy is an exciting field of research. Continuous technical breakthroughs in NMR help push the boundary of its applications. Well-ordered as well as disordered proteins can be investigated in detail by NMR. Furthermore, solution NMR provides an opportunity to monitor protein conformation and dynamics in live cells. Our research group focuses on the conformation, interaction, and aggregation of intrinsically disordered proteins (IDPs) and their implication in disease. We aim at enhancing the accuracy and sensitivity of NMR analysis by designing new pulse sequences and instruments.

• Ph.D. Biophysics, University of Wisconsin-Madison, USA, 2008-2013
• M.S. Interdisciplinary Program in Genetic Engineering, Seoul National University, Korea, 2005-2007
• B.S. Mechanical and Aerospace Engineering, Physics (double major), Seoul National University, Korea, 1997-2002

• Researcher, Lab of Computational Biology and Biomolecular Engineering, Seoul National University, 2008
• Postdoctoral Fellow, Laboratory of Chemical Physics, NIDDK, NIH, USA, 2014-2016

1. Lee, J.; Park, S. H.; Cavagnero, S.; Lee, J. H. High-resolution diffusion measurements of proteins by NMR under near-physiological conditions. Anal. Chem. 2020, 92, 5073-5081.
2. Park, S. H.; Lee, J. H. Dynamic GPCR signaling probed by solution NMR spectroscopy. Biochemistry, 2020, 59, 1065-1080.
3. Im, J.; Lee, J.; Lee, J. H. Pre-homonuclear decoupling enables high-resolution NMR analysis of intrinsically disordered proteins in solution. J. Phys. Chem. Lett. 2019, 10, 4720-4724.
4. Alderson, T. R.; Lee, J. H.; Charlier, C.; Ying, J.; Bax, A. Propensity for cis-proline formation in unfolded proteins. ChemBioChem 2018, 19, 37-42.
5. Lee, J. H.; Zhang, D.; Hughes, C.; Okuno, Y.; Sekhar, A.; Cavagnero, S. Heterogeneous binding of the SH3 client protein to the DnaK molecular chaperone. Proc. Natl. Acad. Sci. U.S.A. 2015, 112, E4206-E4215.
6. Lee, J. H.; Li, F.; Grishaev, A.; Bax, A. Quantitative residue-specific protein backbone torsion angle dynamics from concerted measurement of 3J couplings. J. Am. Chem. Soc. 2015, 137, 1432-1435.