Cu-Catalyzed Asymmetric Hydroamination Processes in Organic Synthesis
소속 :
연사 : Stephen L. Buchwald(Department of Chemistry, MIT)
일시 : 2016-05-18 16:30 ~
장소 : 500동, 목암홀
The net addition of an N-H group across a carbon–carbon double bond
represents an extremely efficient method to access amines. In particular, the
ability to conduct this transformation in a general and enantioselective
manner is quite attractive. In this lecture, we will describe our success in
developing a highly regio- and enantioselective process for the hydroamination
of a wide range of olefinic substrates. We will also detail our
studies in reaction optimization achieved by way of mechanistic studies.
represents an extremely efficient method to access amines. In particular, the
ability to conduct this transformation in a general and enantioselective
manner is quite attractive. In this lecture, we will describe our success in
developing a highly regio- and enantioselective process for the hydroamination
of a wide range of olefinic substrates. We will also detail our
studies in reaction optimization achieved by way of mechanistic studies.
