Biopolymer-based nanomaterials for gene and drug delivery
소속 :
연사 : Prof. Won Jong Kim ( Postech )
일시 : 2013-05-16 16:30 ~
장소 : 500동 목암홀
일 시 : 2013년 5월 16일, 4:30 PM
장 소 : 500동 목암홀
-Abstract-
Gene therapy has attracted enormous attention over the past few decades due to its immense potential as a therapeutic tool for combating various genetic disorders. Among two kinds of vectors that are employed till date, viral vectors exhibit higher transfection efficiencies, but their use is impaired greatly due to the associated toxicity, immunogenicity, and non-viable scale up procedures. As a result, tremendous impetus has been directed toward the development of various nonviral synthetic delivery systems which could be safer and more efficient. A number of cationic polymers including polyethylenimine (PEI), chitosan, and poly(L-lysine) have also been reported to exhibit efficient gene transfection. However, the induced cytotoxicity and non-biodegradability of these cationic polymeric vectors along with inefficient release of gene from the polymeric complexes inside the cell, lack of target specificity impede the prevalent practical realization of gene therapy. Therefore, in our quest to develop a highly coveted vector which could provide all these attributes, we have devised several highly efficient vector systems. Our approaches are focused mainly on the development of smart polymeric biomaterials which could exploit the intracellular and extracellular features of the target cells by imparting several structural or functional traits into the nanoconstructs in order to overcome various impediments.
장 소 : 500동 목암홀
-Abstract-
Gene therapy has attracted enormous attention over the past few decades due to its immense potential as a therapeutic tool for combating various genetic disorders. Among two kinds of vectors that are employed till date, viral vectors exhibit higher transfection efficiencies, but their use is impaired greatly due to the associated toxicity, immunogenicity, and non-viable scale up procedures. As a result, tremendous impetus has been directed toward the development of various nonviral synthetic delivery systems which could be safer and more efficient. A number of cationic polymers including polyethylenimine (PEI), chitosan, and poly(L-lysine) have also been reported to exhibit efficient gene transfection. However, the induced cytotoxicity and non-biodegradability of these cationic polymeric vectors along with inefficient release of gene from the polymeric complexes inside the cell, lack of target specificity impede the prevalent practical realization of gene therapy. Therefore, in our quest to develop a highly coveted vector which could provide all these attributes, we have devised several highly efficient vector systems. Our approaches are focused mainly on the development of smart polymeric biomaterials which could exploit the intracellular and extracellular features of the target cells by imparting several structural or functional traits into the nanoconstructs in order to overcome various impediments.
