Structures and Reaction Dynamics of Proteins and Other Biomolecules in multi-component Systems
소속 :
연사 : Hugh I. Kim(Postech Chemistry)
일시 : 2012-11-01 17:00 ~
장소 : 25-1동 국제회의실
일 시 : 2012년 11월 1일, 5:00 PM
장 소 : 25-1동 국제회의실
-Abstract-
Chemistry in complex system is ubiquitous in nature and anthropomorphic processes, yet we have only begun to understand and harness such reactions. For identification of the reactions and structures of biomolecules in multi-component systems, various instrumentation techniques, along with theoretical methods are utilized. Several examples of these studies will be presented, including the host-guest chemistry of proteins and oxidation of biomolecules in interfacial surfactant layers. The latter studies elucidate the response of the lung pulmonary surfactant layer to conditions of oxidative stress. For example, oxidations of unsaturated phospholipids and surfactant layer protein by ozone alternate compositions and physical properties of surfactant layers. Combining experimental observations with the results of molecular dynamics simulations provides an improved understanding of the interfacial structure and chemistry of a model lung surfactant system when subject to oxidative stress.
Cucurbit[n]uril (CB[n], n = 5-10) and 18-crown-6 (18C6) are neutral cyclic molecules, which are efficient host molecules in molecular recognition and have high affinity for positively charged or cationic compounds. Their host-guest properties allow various applications of these molecules including drug deliveries, reaction catalysts, etc. In this seminar, the host-guest property of CB[6] and 18C6 to lysine residues will be discussed along with its unique applications to probe and control structures of proteins.
장 소 : 25-1동 국제회의실
-Abstract-
Chemistry in complex system is ubiquitous in nature and anthropomorphic processes, yet we have only begun to understand and harness such reactions. For identification of the reactions and structures of biomolecules in multi-component systems, various instrumentation techniques, along with theoretical methods are utilized. Several examples of these studies will be presented, including the host-guest chemistry of proteins and oxidation of biomolecules in interfacial surfactant layers. The latter studies elucidate the response of the lung pulmonary surfactant layer to conditions of oxidative stress. For example, oxidations of unsaturated phospholipids and surfactant layer protein by ozone alternate compositions and physical properties of surfactant layers. Combining experimental observations with the results of molecular dynamics simulations provides an improved understanding of the interfacial structure and chemistry of a model lung surfactant system when subject to oxidative stress.
Cucurbit[n]uril (CB[n], n = 5-10) and 18-crown-6 (18C6) are neutral cyclic molecules, which are efficient host molecules in molecular recognition and have high affinity for positively charged or cationic compounds. Their host-guest properties allow various applications of these molecules including drug deliveries, reaction catalysts, etc. In this seminar, the host-guest property of CB[6] and 18C6 to lysine residues will be discussed along with its unique applications to probe and control structures of proteins.
