Chiral Brønsted Base Catalyzed Enantioselective Reactions
소속 :
연사 : Tan Choon Hong(Nanyang Technological University)
일시 : 2012-10-25 17:00 ~
장소 : 상산수리과학관
일 시 : 2012년 10월 25일, 5:00 PM
장 소 : 상산수리과학관
-Abstract-
We are keen to develop chiral guanidine as general brønsted base catalyst. We found them to be excellent enantioselective catalysts for Michael, Phospha-Michael and Diels-Alder reactions. In this seminar, we would like to present these reaction and two other reactions relating to the enantioselective transfer of protons. In the first reaction, the conjugate addition of arylthiol to 2-phthalimidoacrylate generates a pro-chiral transient enolate which upon protonation gave cysteine analogues with high enantioselectivities. In the second reaction, we showed that guanidine catalyze the 1,3-proton shift reaction, allowing chiral allenes to be prepared directly from alkynes.
장 소 : 상산수리과학관
-Abstract-
We are keen to develop chiral guanidine as general brønsted base catalyst. We found them to be excellent enantioselective catalysts for Michael, Phospha-Michael and Diels-Alder reactions. In this seminar, we would like to present these reaction and two other reactions relating to the enantioselective transfer of protons. In the first reaction, the conjugate addition of arylthiol to 2-phthalimidoacrylate generates a pro-chiral transient enolate which upon protonation gave cysteine analogues with high enantioselectivities. In the second reaction, we showed that guanidine catalyze the 1,3-proton shift reaction, allowing chiral allenes to be prepared directly from alkynes.
