Entries to Hydroxylated Cyclohexa(e)nes via Carbocyclization of Carbohydrates
소속 :
연사 : Prof. Tony Kung Ming SHING(The Chinese University of Hong Kong)
일시 : 2012-06-15 16:30 ~
장소 : 500동 L307호
일 시 : 2012년 6월 15일, 4:30 PM
장 소 : 500동 L307호
-Abstract-
We have been conducting research on the carbocyclization of carbohydrates for many years, i.e. the conversion of simple, readily available monosaccharides into hydroxylated carbocycles with pharmaceutical potential. Several key reactions will be presented in the seminar to illustrate such transformation namely intramolecular Watsworth-Emmon-Horner olefination, [π4s+π2s] cycloaddition, namely intramolecular nitrone and nitrile oxide-alkene cycloaddtion, and intramolecular aldol reactions. These protocols provide facile entries to 5, 6, as well as 7-membered hydroxylated carbocycles in enantiomerically pure forms.
장 소 : 500동 L307호
-Abstract-
We have been conducting research on the carbocyclization of carbohydrates for many years, i.e. the conversion of simple, readily available monosaccharides into hydroxylated carbocycles with pharmaceutical potential. Several key reactions will be presented in the seminar to illustrate such transformation namely intramolecular Watsworth-Emmon-Horner olefination, [π4s+π2s] cycloaddition, namely intramolecular nitrone and nitrile oxide-alkene cycloaddtion, and intramolecular aldol reactions. These protocols provide facile entries to 5, 6, as well as 7-membered hydroxylated carbocycles in enantiomerically pure forms.
