Unprecedented 3D Molecular Architectures: Folding into Shape
소속 :
연사 : Prof. Hee-Seung Lee(Department of Chemistry, KAIST)
일시 : 2012-04-20 17:00 ~
장소 : 500동 목암홀
일 시 : 2012년 4월 20일, 5:00 PM
장 소 : 500동 목암홀
-Abstract-
Molecular self-assembly is the spontaneous assembly of molecules into structured aggregates by which nature builds complex functional systems. While numerous examples have focused on 2D selfassembly to understand the underlying mechanism and mimic this process to create artificial nanoand microstructures, a limited progress has been made toward 3D self-assembly on the molecular level. This lack of progress is partially due to the difficultly of designing and using nondirectional noncovalent interactions, such as van der Waals and hydrophobic interactions, in synthetic, nonbiological molecular systems. Thus, we sought to establish a set of self-assembling components that could be linked to observable 3D shapes by which the governing parameters of self-assembly could be disentangled and tractable.
Recently, we discovered that artificial protein fragments (helical -peptide foldamers) with welldefined hydrophobic surfaces self-assembled to form unprecedented 3D molecular architectures (“foldectures”) in a controlled manner in aqueous solution.1-3 We anticipate that our strategy can be a starting point for the rational design of 3D organic molecular architectures with various functions. Furthermore, the self-assembly behavior of artificial protein fragments will be relevant for the development of synthetic foldamer proteins.
장 소 : 500동 목암홀
-Abstract-
Molecular self-assembly is the spontaneous assembly of molecules into structured aggregates by which nature builds complex functional systems. While numerous examples have focused on 2D selfassembly to understand the underlying mechanism and mimic this process to create artificial nanoand microstructures, a limited progress has been made toward 3D self-assembly on the molecular level. This lack of progress is partially due to the difficultly of designing and using nondirectional noncovalent interactions, such as van der Waals and hydrophobic interactions, in synthetic, nonbiological molecular systems. Thus, we sought to establish a set of self-assembling components that could be linked to observable 3D shapes by which the governing parameters of self-assembly could be disentangled and tractable.
Recently, we discovered that artificial protein fragments (helical -peptide foldamers) with welldefined hydrophobic surfaces self-assembled to form unprecedented 3D molecular architectures (“foldectures”) in a controlled manner in aqueous solution.1-3 We anticipate that our strategy can be a starting point for the rational design of 3D organic molecular architectures with various functions. Furthermore, the self-assembly behavior of artificial protein fragments will be relevant for the development of synthetic foldamer proteins.
