Nanoparticles for imaging, drug delivery, and photodynamic therapy
소속 :
연사 : Dr. Heebeom Koo(Center for Theragnosis, KIST)
일시 : 2012-04-09 17:00 ~
장소 : 500동 L302호
일 시 : 2012년 4월 9일, 5:00 PM
장 소 : 500동 L302호
-Abstract-
Nanotechnology is an interdisciplinary and multidisciplinary research field involving chemistry, physics, material science, biology, and medicine. Especially, nanotechnology is currently offering various exciting possibilities in biomedical fields, and this application is referred to as the word ‘nanomedicine’. Due to the importance of this spotlighted field, it is expected that the global market related with the applications of nanotechnology in the medical field could increase to about $70-160 billion by 2015. Nanoparticles (NPs) were initially developed to improve the pharmacokinetics of drugs, but they unexpectedly received much attention from researchers and have become the center of this promising trend of nanomedicine. They have been widely used due to the following advantageous aspects: (1) small molecule imaging agent or drugs, NPs can easily integrate more than one kind of imaging or therapeutic agent, which make them potential multifunctional nanoplatforms for both diagnosis and therapy; (2) Due to their large compartments (e.g. large surface area or interior cargo volume), considerable amounts of imaging agents or drugs can be introduced into NPs through simple loading and chemical conjugation; (3) With specific targeting moieties or physicochemical optimization of size and surface properties, NPs can target disease site for drug delivery and imaging. More than one targeting molecule can greatly enhance target-binding and specificity compared to single molecules due to so-called multivalent effects; (4) Appropriate size and surface modification of NPs can lead to enhanced circulation time in the blood reducing opsonization and uptake into the reticuloendothelial system (RES). These features provide NPs with great potential as innovative diagnostic and therapeutic systems for the clinical field.
장 소 : 500동 L302호
-Abstract-
Nanotechnology is an interdisciplinary and multidisciplinary research field involving chemistry, physics, material science, biology, and medicine. Especially, nanotechnology is currently offering various exciting possibilities in biomedical fields, and this application is referred to as the word ‘nanomedicine’. Due to the importance of this spotlighted field, it is expected that the global market related with the applications of nanotechnology in the medical field could increase to about $70-160 billion by 2015. Nanoparticles (NPs) were initially developed to improve the pharmacokinetics of drugs, but they unexpectedly received much attention from researchers and have become the center of this promising trend of nanomedicine. They have been widely used due to the following advantageous aspects: (1) small molecule imaging agent or drugs, NPs can easily integrate more than one kind of imaging or therapeutic agent, which make them potential multifunctional nanoplatforms for both diagnosis and therapy; (2) Due to their large compartments (e.g. large surface area or interior cargo volume), considerable amounts of imaging agents or drugs can be introduced into NPs through simple loading and chemical conjugation; (3) With specific targeting moieties or physicochemical optimization of size and surface properties, NPs can target disease site for drug delivery and imaging. More than one targeting molecule can greatly enhance target-binding and specificity compared to single molecules due to so-called multivalent effects; (4) Appropriate size and surface modification of NPs can lead to enhanced circulation time in the blood reducing opsonization and uptake into the reticuloendothelial system (RES). These features provide NPs with great potential as innovative diagnostic and therapeutic systems for the clinical field.
