Role of mitochondrial Sir2 proteins in metabolism and aging
소속 :
연사 : Prof. Marcia Haigis (Harvard Medical School)
일시 : 2009-10-12 17:00 ~
장소 : 500동 목암홀
일시: 2009년 10월 12일 오후 5:00
장소: 500동 목암홀
-Abstract-
Sir2 is an NAD-dependent deacetylase that connects metabolism with longevity in yeast, flies, and worms. Mammals contain seven homologs of yeast Sir2 (SIRT1-7), which regulate multiple age-associated diseases, including cancer, diabetes and neurodegeneration. Three sirtuins (SIRT3-5) reside in the mitochondria and play a role in coordinating mitochondrial metabolism to facilitate nutrient adaptation. I will discuss the roles of these sirtuins in mitochondrial energy production.
장소: 500동 목암홀
-Abstract-
Sir2 is an NAD-dependent deacetylase that connects metabolism with longevity in yeast, flies, and worms. Mammals contain seven homologs of yeast Sir2 (SIRT1-7), which regulate multiple age-associated diseases, including cancer, diabetes and neurodegeneration. Three sirtuins (SIRT3-5) reside in the mitochondria and play a role in coordinating mitochondrial metabolism to facilitate nutrient adaptation. I will discuss the roles of these sirtuins in mitochondrial energy production.
