Woon Ju SongAssistant Professor

Current Research Interests
Our research lies in the interdisciplinary studies of inorganic chemistry, biochemistry, protein engineering that we employ spectroscopic, kinetic, thermodynamic, and biochemical techniques/analysis to understand orchestrated chemical reactions of metalloproteins and metalloenzymes. We aim to design and synthesize metal/protein-based biocatalysts and biomaterials that can be further adapted for targeting structures and/or functionalities. Additionally, we are interested in the creation of bioinorganic tools to regulate biological systems such as antibiotic resistance, bacterial communications, and carbon and nitrogen fixation pathways.

Ph.D. Inorganic Chemistry, MIT, USA, 2011 (Prof. Stephen J. Lippard)
M.S. Chemistry, Ewha Womans University, Republic of Korea, 2005 (Prof. Wonwoo Nam)
B.S. Science/Chemistry Education, Ewha Womans University, Republic of Korea, 2003

Research Experiences
Assistant Professor, Department of Chemistry, Seoul National University, Republic of Korea, 2016-Present
Postdoctoral Scholar, Department of Chemistry and Biochemistry, University of California, San Diego, USA, 2011-2015 (Prof. F. Akif Tezcan)

Representative Publications
Woon Ju Song, F. Akif Tezcan ¡°De Novo Design of an Artificial ¥â-Lactamase Exhibiting In Vitro and In Vivo Catalysis¡± Science, 2014, 346, 1525-1528. This work was highlighted in Nat. Chem. 2015, 7, 277-279.

Woon Ju Song,¢Ó Pamela A. Sontz,¢Ó Xavier Ambroggio, F. Akif Tezcan ¡°Metals in Protein-Protein Interfaces¡± Annu. Rev. Biophys., 2014, 43, 409-431 ¢Ó¢Ó These authors contributed equally to this work.

Woon Ju Song, Grant Gucinski, Matthew H. Sazinsky, Stephen J. Lippard ¡°Tracking a Defined Route for O2-Migration in a Dioxygen-Activating Diiron Enzyme¡± Proc. Natl. Acad. Sci., 2011, 108, 14795-14800

Woon Ju Song, Michael S. McCormick, Rachel K. Behan, Matthew H. Sazinsky, Wei Jiang, Jeffery Lin, Carsten Krebs, Stephen J. Lippard ¡°Active Site Threonine Facilitates Proton Transfer during Dioxygen Activation at the Diiron Center of Toluene/o-Xylene Monooxygenase Hydroxylase¡± J. Am. Chem. Soc. 2010, 132, 13582-13585.

Woon Ju Song, Rachel K. Behan, Sunil G. Naik, Boi Hanh Huynh, Stephen J. Lippard ¡°Characterization of a Peroxodiiron(III) Intermediate in the T201S Variant of Toluene/o-Xylene Monooxygenase Hydroxylase from Pseudomonas sp. OX1¡± J. Am. Chem. Soc. 2009, 131, 6074-6075

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